A5068773070- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Hernia repair and management
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Kidney Stones and Urolithiasis Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Polyomavirus and related diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Parathyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Renal and Vascular Pathologies
- Ureteral procedures and complications
- Genetic Syndromes and Imprinting
- Thyroid and Parathyroid Surgery
- Liver physiology and pathology
- Urological Disorders and Treatments
Washington University in St. Louis
2017-2021
University of Illinois Chicago
2016
University of Illinois Urbana-Champaign
2016
Illinois College
2016
Research Institute Hospital 12 de Octubre
2012
Obesity represents a barrier to kidney transplantation, but the increasing prevalence among renal failure patients has forced some centers carefully consider such candidates. Morbidly obese may be at increased risk of delayed graft function, higher postoperative complications, and inferior outcomes. Nevertheless, mortality on waiting list remains significantly than after transplant. We have applied minimally invasive surgery perform transplant in individuals with body mass index (BMI) 40...
We investigated whether blockade of the CD47 signaling pathway could reduce ischemia-reperfusion injury (IRI) renal allografts donated after cardiac death (DCD) in a porcine animal model transplantation. Renal were subjected to 30 minutes warm ischemia, 3.5 hours cold and then perfused with humanized anti-CD47 monoclonal antibody (CD47mAb) treatment group or HTK solution control (n = 4/group). The animals euthanized five days At time reperfusion, indocyanine green-based vivo imaging showed...
Liver transplantation (LT) is a complex operation that most transplant surgeons learn in fellowship. Training varies as there lack of objective data can be used to standardize teaching. We performed retrospective review our adult LT database with aim looking at fellow's experience. Using American Society Transplant Surgery cutoff of, least 45 during fellowship, for first were compared 45-90. Fellow's cases also clustered sequential groups 15 and analyzed estimate the learning curve (LC)....
Toward the goal of using more livers for transplantation, transplant centers are looking to increase use organs from "marginal" donors. Livers these donors, however, have been shown be susceptible preservation and reperfusion injury.Using a porcine model donation after circulatory death, we studied antibody-mediated CD47 blockade further improve liver graft function undergoing normothermic machine perfusion. 20 pigs (5 per group) were brought under either 30 or 60 min warm ischemia time...
It remains controversial whether renal allografts from donation after circulatory death (DCD) have a higher risk of acute rejection (AR). In the porcine large animal kidney transplant model, we investigated AR and function DCD compared to non-DCD effects increased immunosuppression. We found that was significantly along with elevated MHC-I expression in transplants receiving low-dose immunosuppression; however, were improved when given high-dose immunosuppressive therapy postoperatively....
Introduction: The acceptance of non-heart-beating donors (NHBD) emerges as a consequence the shortage organs and increased mortality in waiting list. use these grafts implies higher risk primary graft dysfunction (PGD) well ischemic cholangiopathy (IC). Classically, liver function tests (LFT) (AST-ALT) ischemia times, macroscopic aspect are used determining factors accepting organs. Patients methods: Between January 2006 December 2011, we performed 380 OLT. 48 transplants were NHBD...
Introduction: Since the beginning of non-heart-beating donor (NHBD) (Maastricht II) program in our hospital, problem to improve these donors order get maximum number organs, was planned. Thoracic surgeons need a cold donor, whereas liver normothermic donors, best outcomes. This is not yet solved at moment, and nowadays an important NHBD transplant program. We aim calculate impact lungs' cooling on transplant. Patients methods: Between January 2009 June 2011, 145 transplants were performed,...
Introduction: Sarcoidosis is a rare disease characterized by the formation of epitheloid non-caseating granulomas and can affect various organs body. The liver usually affected these (70-90%), but it silent, although in occasions produce complications sucha as jaundice, failure, cirrhosis, portal hypertension. A transplantation be performed patients with cirrhosis secondary to an intrahepatic cholestasis due sarcoidosis. We present case hepatic sarcoidosis transplated “12 de Octubre”...
Introduction: The shortage of donor pool forces us to optimize the use donors. macrosteatosis graft was considered as an exclusion criterion in past times, but nowadays they are no longer rejected only because this finding. Material and methods: Between March 1990 December 2009 we performed 1235 OLT. From period selected a sample 490 patients with complete pathological data donor. All had minimum 2 year follow-up. They were divided 3 groups: group A: microsteatosis (158 patients), B: (78 C:...
Introduction: Primary hyperoxaluria (PHO) type I is an autosomic recessive disease caused by a deficiency of alanine-glyoxylate aminotransferase in the hepatocyte. The this enzyme causes excessive production and excretion kidneys oxalate glycolate. These substances are precipitated kidneys, renal failure occurs. When only kidney transplantation performed, excess deposits graft affecting survival patients. In these patients, hepatorenal best option since it treats its origin corrected....