A5063933353- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Ear and Head Tumors
- Neutropenia and Cancer Infections
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Head and Neck Surgical Oncology
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Global Cancer Incidence and Screening
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Prostate Cancer Diagnosis and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- HER2/EGFR in Cancer Research
- Cancer Risks and Factors
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
Washington University in St. Louis
2016-2025
American College of Surgeons
2022
Alvin J. Siteman Cancer Center
2016-2021
Jewish Hospital
2021
Barnes-Jewish Hospital
2021
Arizona State University
2019
Yale University
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
Male and female glioblastomas are biologically distinct, improving outcomes may require sex-specific approaches to treatment.
Abstract Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association ET change uptake progestin analog, 21-[ 18 F]fluorofuranylnorprogesterone (FFNP), before and after one-day challenge. 43 postmenopausal women advanced...
Background: Spinal metastases are a significant cause of morbidity in patients with advanced cancer, and management often requires surgical intervention. Although prior studies have identified factors that influence outcomes surgery, the ability these to predict remains unclear era contemporary therapies, there is need better identify who likely benefit from surgery. Methods: We performed single-center, retrospective analysis evaluate risk for poor spinal treated The primary outcome was...
The objective of this study was to assess the efficacy diffusion-weighted MRI (DWI) in monitoring response radiotherapy high-risk prostate cancer (PC).This retrospective included 78 patients with PC undergoing 3.0-T (supplemented by DWI) before and after intensity-modulated (IMRT). Based on follow-up clinical examinations, were divided into two groups: recurrence group (patients who suffered biochemical/clinical within 3 years, n = 13) non-recurrence free for over 65). apparent diffusion...
PurposeThe long-term effects of neoadjuvant androgen deprivation therapy (NADT) with radiation on participant-reported health-related quality life (HRQOL) have not been characterized in prospective multicenter studies. We evaluated HRQOL for 2 years among participants undergoing (RT) or without NADT newly diagnosed, early-stage prostate cancer.Methods and MaterialsWe analyzed longitudinal cohort data from the Prostate Cancer Outcomes Satisfaction Treatment Quality Assessment Consortium to...
Background Modest survival rates are published for treatment of oral squamous cell carcinoma (OSCC) using conventional approaches. Few cohort studies available transoral resection OSCC. Methods Analysis recurrence, survival, and prognosis patients with OSCC treated laser microsurgery (TLM) ± neck dissection was obtained from a prospective database. Results Ninety‐five (71 had stages T1–T2 24 T3–T4 disease) minimum follow‐up months met criteria demonstrated negative margins in 95%. Five‐year...
We investigated whether blockade of the CD47 signaling pathway could reduce ischemia-reperfusion injury (IRI) renal allografts donated after cardiac death (DCD) in a porcine animal model transplantation. Renal were subjected to 30 minutes warm ischemia, 3.5 hours cold and then perfused with humanized anti-CD47 monoclonal antibody (CD47mAb) treatment group or HTK solution control (n = 4/group). The animals euthanized five days At time reperfusion, indocyanine green-based vivo imaging showed...
Purpose To identify modifiable risk factors associated with prolonged clearance of methotrexate in pediatric, adolescent, and young adult (AYA) oncology patients receiving high dose (HDMTX). Design/Method A single institution, retrospective chart review HDMTX between 2010-2017. Patients had a diagnosis either leukemia or osteosarcoma. Data included demographics, concurrent intravenous (IV) medications, IV fluids (IVF) administered, urine output (UO), rises serum creatinine (RSC) reflective...
To compare wound complication rates after skin closure with staples and subcuticular suture in obese gynecology patients undergoing laparotomy through a midline vertical incision.
The Joanne Knight Breast Health Cohort was established to link breast cancer risk factors, mammographic density, benign biopsies and associated tissue markers, blood markers in a diverse population of women undergoing routine screening study factors validate models for prediction.
Abstract We previously reported that nab ‐paclitaxel‐based induction chemotherapy ( IC ) and concurrent chemoradiotherapy resulted in low relapse rates (13%) excellent survival head neck squamous cell carcinoma HNSCC ). compare the disease‐specific DSS overall OS between patients given ‐paclitaxel, cisplatin, fluorouracil with cetuximab APF ‐C) historical controls docetaxel, TPF ‐C). Patients locally advanced were treated ‐C n = 30) or 38). After 3 cycles of , scheduled to receive cisplatin...
Background: Activation of the mTOR pathway has been implicated in development several malignancies and alterations TSC1, TSC2, STK11 NF1, can lead to dysregulation this pathway. Furthermore, mutations TSC1 NF2 are known confer sensitivity everolimus—an inhibitor. Based on these data, a single-arm, open label, single-institution phase II basket study was designed assess activity everolimus patients with solid whose tumors harbored NF2, or STK11.Methods: A total 12 histologically confirmed...
To describe the prevalence and correlates of high-grade cervical intraepithelial neoplasia (CIN2+) after a negative loop electrosurgical excision procedure (LEEP), performed for squamous lesion (HSIL) cytology.One hundred six women from our university-based colposcopy clinic underwent LEEP between 2007 2014. Negative was defined as CIN1 or less. Persistence/recurrence estimates were calculated by treatment (see-and-treat vs 3-step conventional strategy-cervical cytology, colposcopic biopsy,...
Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There limited research on the dosing, infusion times, and schedules administration their impact loss.A retrospective review 993 pediatric patients' medical audiological charts from August 1990 to March 2015 was conducted using stringent inclusion criteria characterize patients with loss. 248 these received CDDP. Of these, 216 had sufficient CDDP data assess for sensorineural attributable its associated risk factors....
ABSTRACT Background Appreciable local recurrence rates observed in patients with margin‐negative, transoral laser microsurgery (TLM)‐treated oral cavity squamous cell carcinoma (SCC) necessitate identification of new prognosticators for control and survival. A histopathologic index (Brandwein–Gensler score [BGS]) intrinsic/iatrogenic/chronic conditions causing immune compromise are investigated. Methods From a prospectively assembled database TLM‐treated SCC, specimens 60 minimum 2‐years...
Abstract Background Clostridioides difficile infection (CDI) is a significant source of morbidity in pediatric cancer patients. Few reports to date have evaluated risk factors and short-term outcomes for this population. Methods We retrospectively oncology admissions at St Louis Children’s Hospital from 2009 2018. All inpatient cases diagnosed initial CDI were identified. aimed investigate the prevalence associated factors, including coadmission with another patient CDI, evaluate length stay...