A5101418717- Tendon Structure and Treatment
- Foot and Ankle Surgery
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Advanced Radiotherapy Techniques
- Sarcoma Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Bee Products Chemical Analysis
- Cardiac tumors and thrombi
- Medical Imaging Techniques and Applications
- Shoulder and Clavicle Injuries
- Bone Tumor Diagnosis and Treatments
- Mining and Gasification Technologies
- 3D Printing in Biomedical Research
- Nerve Injury and Rehabilitation
- Laser Applications in Dentistry and Medicine
- Cardiac Imaging and Diagnostics
- Atomic and Subatomic Physics Research
- Transcranial Magnetic Stimulation Studies
- Advanced Power Generation Technologies
Huashan Hospital
2017-2025
Fudan University
2017-2025
Fudan University Shanghai Cancer Center
2021-2024
Shanghai Medical College of Fudan University
2021-2024
Shanghai Institute of Hematology
2021-2024
Shanghai Clinical Research Center
2024
Siemens Healthcare (Germany)
2024
Scripps (United States)
2022
Scripps Institution of Oceanography
2022
Scripps Research Institute
2022
The new principle and technique to tune biodegradation rates of biomaterials is one the keys development regenerative medicine next-generation biomaterials. Biodegradable stents are new-generation medical devices applied in percutaneous coronary intervention, etc. Recently, both corrodible metals degradable polymers have drawn much attention biodegradable or scaffolds. It is, however, a dilemma achieve good mechanical properties appropriate degradation profiles. Herein, we put forward...
Osteoarthritis (OA) features ageing-related defects in cellular homeostasis mechanisms articular cartilage. These are associated with suppression of forkhead box O (FoxO) transcription factors. FoxO1 or FoxO3 deficient mice show early onset OA while protects against oxidative stress chondrocytes and promotes expression autophagy genes the essential joint lubricant proteoglycan 4 (PRG4). The objective this study was to identify small molecules that can increase expression.
Background Deep learning (DL)–based MRI reconstructions can reduce imaging times for turbo spin-echo (TSE) examinations. However, studies that prospectively use DL-based of rapidly acquired, undersampled in the shoulder are lacking. Purpose To compare acquisition time, image quality, and diagnostic confidence DL-reconstructed TSE (TSEDL) with standard patients indicated MRI. Materials Methods This prospective single-center study included consecutive adult various abnormalities who were...
To test the efficacy of low-dose extracorporeal shockwave therapy (ESWT) on osteoarthritis knee pain, lower limb function, and cartilage alteration for patients with osteoarthritis.Randomized controlled trial placebo control.Outpatient physical clinics within a hospital network.Eligible volunteers (N=63) (Kellgren-Lawrence grade II or III) were randomly assigned to 2 groups.Patients in experimental group received ESWT 4 weeks while those got sham therapy. Both groups maintained usual level...
Due to image quality limitations, online Megavoltage cone beam CT (MV CBCT), which represents real patient anatomy, cannot be used perform adaptive radiotherapy (ART). In this study, we a deep learning method, the cycle-consistent adversarial network (CycleGAN), improve MV CBCT and Hounsfield-unit (HU) accuracy for rectal cancer patients make generated synthetic (sCT) eligible ART. Forty treated with intensity modulated (IMRT) were involved in study. The images of 30 model training,...
Purpose To quantitatively evaluate the cartilage alteration of talus for chronic lateral ankle instability (LAI) with isolated anterior talofibular ligament (ATFL) tear and combined ATFL calcaneofibular (CFL) using T 2 ‐mapping at 3.0T. Materials Methods In all, 27 patients including 17 10 ATFL+CFL tear, 21 healthy subjects were recruited. All participants underwent scan 3T completed American Orthopaedic Foot Ankle Society (AOFAS) scoring. The total talar (TTC) was segmented into six...
Background: It has been reported that insertion-preserved hamstring tendon autografts (IP-HT) have better maturity than free (FHT) at 2 years after anterior cruciate ligament reconstruction (ACLR); however, whether insertion preservation improves the of entire autograft and clinical outcomes 5 ACLR is still unclear. Purpose: To investigate different segments using up to ACLR. Study Design: Randomized controlled trial; Level evidence, 2. Methods: 45 patients who underwent isolated with were...
Background: Previous studies have examined patients with chronic lateral ankle instability (CLAI) undergoing open and arthroscopic anterior talofibular ligament (ATFL) reconstruction, reporting equivalent clinical results between the 2 procedures. However, data on magnetic resonance imaging (MRI) outcomes cartilage health after procedures are limited. Purpose: To compare MRI T2 values of talar subtalar joints CLAI ATFL reconstruction. Study Design: Cohort study; Level evidence, 3. Methods: A...
To quantitatively assess changes in cartilage matrix after acute anterior cruciate ligament (ACL) rupture using T2- and T2⁎-mapping analyze the correlation between results of both methods.Twenty-three patients 23 healthy controls were enrolled underwent quantitative MRI examination. The knee was segmented into six compartments, including lateral femur (LF), tibia (LT), medial (MF), (MT), trochlea (Tr), patella (Pa). T2 T2⁎ values measured full-thickness as well superficial deep layers each...
Material surfaces can induce cell responses such as contact guidance, yet little attention has been paid to further orientation. Herein, we report an interesting phenomenon of orientation beyond the classic guidance on a stripe‐like micropattern with cell‐adhesive arginine‐ glycine‐aspartate (RGD) peptides nonfouling background decorated by poly(ethylene glycol) (PEG). Such adhesion contrast led significant after seeding. What is more, localized and elongated cells were found be orientated...
To investigate the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features for predicting hypoxia-inducible factor 1-alpha (HIF-1α) expression and patient outcomes in soft tissue sarcoma (STS).We enrolled 71 patients with STS who underwent 3.0 Tesla (3.0T) MRI, including conventional MRI DCE-MRI sequencing. The location, maximum tumor diameter, envelope, T2-weighted heterogeneity, peritumoral edema, enhancement, necrosis, configuration, tail-like pattern, bone...
Objective This study aimed to assess the association between synovial fluid (SF) metabolites and magnetic resonance imaging (MRI) measurements of cartilage biochemical composition identify potential SF biomarkers for detecting early onset degeneration in a rabbit model. Methods Both knees 12 New Zealand White rabbits were used. The anterior cruciate ligament transection (ACLT) model was performed on right knees, sham surgery left knees. MRI UTE-T2* scanning sample collection ACLT at 4 8...
To quantitatively assess biochemical alterations in the cartilage of subtalar and midtarsal joints chronic lateral ankle instability (CLAI) patients with isolated anterior talofibular ligament (ATFL) injuries combined calcaneofibular (CFL) using MRI T2 mapping.This study was performed according to regulations Committee for Human Research at our institution, written informed consent obtained from all participants. Forty CLAI (26 ATFL 14 CFL injuries) 25 healthy subjects were recruited this...
Background: Cartilage degeneration is a common issue in patients with chronic lateral ankle instability. However, there are limited studies regarding the effectiveness of ligament surgery on preventing talar and subtalar joint cartilage from further degenerative changes. Purpose: To longitudinally evaluate compositional changes using magnetic resonance imaging T2* mapping anatomic anterior talofibular (ATFL)–repaired ATFL-reconstructed ankles to compare them measures asymptomatic controls....
Background Anatomic repair is widely accepted as the primary surgical treatment for chronic lateral ankle instability (CLAI). T2‐mapping a powerful tool quantitative assessment of biochemical changes in cartilage matrix. Purpose To longitudinally evaluate matrix hindfoot joints CLAI patients before and after anatomic by using with magnetic resonance imaging (MRI). Study Type Prospective. Subjects Thirty‐two (males/females = 20/12) 21 healthy controls 13/7). Field Strength/Sequence 3 T;...
Rotator cuff retears occur more often at the proximal region with suture-bridge (SB) technique than typical footprint single-row (SR) technique. Few longitudinal clinical trials have focused on postoperative tendon quality of repaired rotator different regions between 2 techniques.To compare healing and distal SB SR techniques.Cohort study; Level evidence, 3.Included were consecutive patients who underwent arthroscopic repair undertook magnetic resonance imaging (MRI) examinations 3, 6, 12...