A5101844232- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Patient Satisfaction in Healthcare
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- Parathyroid Disorders and Treatments
- Genital Health and Disease
- Healthcare Policy and Management
- Cancer Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Ocular Oncology and Treatments
- Urological Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Primary Care and Health Outcomes
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Intraperitoneal and Appendiceal Malignancies
- Foot and Ankle Surgery
- Amino Acid Enzymes and Metabolism
- Cancer Cells and Metastasis
Mayo Clinic in Florida
2013-2024
WinnMed
2010-2024
Jacksonville College
2009-2024
Icahn School of Medicine at Mount Sinai
2019-2020
New York Eye and Ear Infirmary
2019
10X Genomics (United States)
2018
University of California, San Diego
2010-2016
Nemours Children’s Clinic
2013-2015
Nemours Children's Clinic
2015
University of Rochester Medical Center
2014
Coexpression networks and gene regulatory (GRNs) are emerging as important tools for predicting functional roles of individual genes at a system-wide scale. To enable network reconstructions, we built large-scale expression atlas composed 62,547 messenger RNAs (mRNAs), 17,862 nonmodified proteins, 6227 phosphoproteins harboring 31,595 phosphorylation sites quantified across maize development. Networks in which nodes connected on the basis highly correlated patterns mRNAs were very different...
Abstract Purpose: We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novel molecular target in clear cell renal carcinoma (ccRCC) and examine its role tumor growth viability vitro vivo independently well combination with current U.S. Food Drug Administration (FDA)-approved regimens. Experimental Design: Patient normal ccRCC tissue samples lines were examined for SCD1 expression. Genetic knockdown models targeted inhibition of through use small molecule inhibitor, A939572, analyzed...
Abstract Purpose: Incidence and mortality rates for renal cell carcinoma (RCC) have been rising decades. Unfortunately, the molecular events that support RCC carcinogenesis remain poorly understood. In an effort to gain a better understanding of signaling in clear (cRCC), we investigated antitumor activity secreted frizzled-related protein 1 (sFRP1), negative regulator Wnt signaling. Experimental Design: Genomic profiling cRCC tumors patient-matched normal tissues was done confirmed using...
Background Clear cell renal carcinoma (ccRCC) is the most common kidney cancer. The purpose of this study to define a biological pathway signature and cellular differentiation program in ccRCC. Methodology We performed gene expression profiling early-stage ccRCC patient-matched normal tissue using Affymetrix HG-U133a HG-U133b GeneChips combined with comprehensive bioinformatic analyses, including analysis. results were validated by real time PCR IHC on two independent sample sets. Cellular...
Abstract Purpose: p27 localization and expression has prognostic predictive value in cancer. Little is known regarding patterns of renal cell carcinoma (RCC) or how participates disease progression response to therapy. Experimental Design: RCC-derived lines, primary tumors, normal epithelial cells were analyzed for expression, phosphorylation (T157 the NLS), subcellular localization. lines treated with phosphatidylinositol 3-kinase (PI3K) mammalian target rapamycin (mTOR) inhibitors effects...
Co-deletion of chromosome arms 1p and 19q, characteristic oligodendroglial tumors, was recently found to be mediated by t(1;19)(q10;p10). To evaluate the prevalence 1p19q co-deletion t(1;19) in extraventricular neurocytomas (EVN), we studied tumors from 23 patients, including 13 females 10 males (median age at diagnosis 34 years, range 2-76 years). Fluorescence situ hybridization (FISH) studies were performed with probes targeting 1p36/1q25 19q13/19p13 assess for co-deletion, as well 1...
Abstract Increased angiogenesis and tumor-induced immune evasion are two mechanisms by which clear cell renal carcinoma (ccRCC) proliferate metastasize; however, the relationship between these pathways in human ccRCC is poorly understood. We conducted a nested case–control study using 98 archived tumor samples from patients diagnosed with primary 1990 2006, half of were identified immunohistochemistry (IHC) as either programmed death ligand 1 (PDL-1)–positive or PDL-1–negative. RNAs...
There is a pressing need for effective therapies to treat uveal melanoma. Agents that inhibit the c-MET pathway have shown promise in multiple malignancies overexpress c-MET. Herein, we assess expression both primary melanoma and liver metastases of evaluate association with clinical pathologic variables. We retrospectively identified tumor samples from 1 January 1990 2012. utilized immunohistochemistry expression, two pathologists quantified using an H-score (product intensity staining...
Inverted urothelial papilloma is an unusual neoplasm of the urinary tract. Although association between inverted and carcinoma not entirely clear, many studies indicate that patients with are at increased risk for development carcinoma. In addition, aneuploid papillomas have been associated subsequent The objective this study was to determine whether ploidy, MIB-1 proliferative activity, or p53 protein staining in were predictive carcinoma.Fifty-one cases retrieved from Tissue Registry Mayo...
The patient-centered medical home (PCMH) is a key service delivery innovation in health reform. However, there are growing questions about whether the changes clinics promoted by PCMH model lead to improvements patient experience.To test hypothesis that safety-net primary care associated with more positive experience.Multilevel cross-sectional analysis of patients nested within serve them.Primary clinic leaders and throughout City New Orleans safety-net.Dependent variables included ratings...
We report the case of a 66-year-old woman with tumor-induced osteomalacia (TIO) caused by fibroblast growth factor 23 (FGF-23) secreting mesenchymal tumor localized in lumbar vertebra and review other cases to axial skeleton. She presented nontraumatic low back pain spontaneous bilateral femur fractures. Laboratory testing was remarkable for serum phosphorus, phosphaturia, significantly elevated FGF-23 level. Magnetic resonance imaging (MRI) spine showed focal lesion L-4 which hypermetabolic...
Hurricane Katrina destroyed much of the health care infrastructure in and around New Orleans 2005. We describe a natural experiment that occurred afterward, amid efforts to rebuild city’s system, which diverse safety-net clinics were transformed into medical homes. Using surveys clinic leaders administrative data, we found made substantial progress implementing new clinical processes improve access, quality safety, coordination integration. But there was wide variation, with some making only...