Jan de Witt

ORCID: 0000-0003-2799-1097
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About
Contact & Profiles
Research Areas
  • biodegradable polymer synthesis and properties
  • Microplastics and Plastic Pollution
  • Microbial Metabolic Engineering and Bioproduction
  • Enzyme-mediated dye degradation
  • Biopolymer Synthesis and Applications
  • Click Chemistry and Applications
  • Polymer crystallization and properties
  • Magnetic Properties and Applications
  • Advanced Sensor Technologies Research
  • Photocathodes and Microchannel Plates
  • Microbial Community Ecology and Physiology
  • Bacterial Genetics and Biotechnology
  • Antimicrobial agents and applications
  • Chemistry and Chemical Engineering
  • Microbial Natural Products and Biosynthesis
  • Microbial bioremediation and biosurfactants
  • Laser Design and Applications
  • Plant biochemistry and biosynthesis
  • Enzyme Catalysis and Immobilization

Forschungszentrum Jülich
1981-2025

University of Münster
2018-2020

Abstract Bio-upcycling of plastics is an emerging alternative process that focuses on extracting value from a wide range plastic waste streams. Such streams are typically too contaminated to be effectively processed using traditional recycling technologies. Medium-chain-length (mcl) diols and dicarboxylates (DCA) major products chemically or enzymatically depolymerized plastics, such as polyesters polyethers. In this study, we enabled the efficient metabolism mcl-diols -DCA in engineered...

10.1186/s12934-024-02310-7 article EN cc-by Microbial Cell Factories 2024-02-16

This study extents the sequence space of 6-aminohexanoate endohydrolases (NylC) for future enzyme engineering strategies to boost their nylonase activities, while in parallel novel polymers were designed align biodegradability and performance.

10.1039/d4gc01662a article EN cc-by Green Chemistry 2024-01-01

Abstract Impranil ® DLN‐SD is a poly(ester‐urethane) (PEU) that widely used as coating material for textiles to fine‐tune and improve their properties. Since coatings increase the complexity of such plastic materials, they can pose hindrance sustainable end‐of‐life solutions plastics using enzymes or microorganisms. In this study, we isolated Halopseudomonas formosensis FZJ due its ability grow on other PEUs sole carbon sources. The strain was exceptionally thermotolerant it could degrade at...

10.1111/1751-7915.14362 article EN cc-by-nc Microbial Biotechnology 2023-11-22

In recent years branched short-chain dicarboxylates (BSCD) such as itaconic acid gained increasing interest in both medicine and biotechnology. Their use building blocks for plastics urges developing microbial upcycling strategies to provide sustainable end-of-life solutions. Furthermore, many BSCD exhibit anti-bacterial properties or exert immunomodulatory effects macrophages, indicating a medical relevance this group of molecules. For these applications, detailed understanding the...

10.1016/j.ymben.2022.12.008 article EN cc-by Metabolic Engineering 2022-12-26

Abstract The Halopseudomonas species, formerly classified as Pseudomonas pertucinogena lineage, form a unique phylogenetic branch within the Pseudomonads. Most strains have recently been isolated from challenging habitats including oil‐ or metal‐polluted sites, deep sea, and intertidal zones, suggesting innate resilience to physical chemical stresses. Despite their comparably small genomes, these bacteria synthesise several biomolecules with biotechnological potential role in degradation of...

10.1111/1751-7915.14369 article EN cc-by-nc Microbial Biotechnology 2023-11-22

In order to develop efficient microbial recycling strategies for rubber waste materials, it is required that we understand the degradation pathway of polymer and how regulated. However, only little known about transcriptional regulation pathway, which seems be upregulated in presence polymer. We identified a novel key regulator (CRP VH2 ) regulates several parts potent rubber-degrader G. polyisoprenivorans VH2. Furthermore, provide evidence widespread involvement CRP regulators various other...

10.1128/aem.00774-20 article EN Applied and Environmental Microbiology 2020-05-22
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