A5100341116- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- HIV-related health complications and treatments
- Child Nutrition and Water Access
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Autoimmune and Inflammatory Disorders Research
- Healthcare Systems and Reforms
- Maternal Mental Health During Pregnancy and Postpartum
- Cervical Cancer and HPV Research
- Assisted Reproductive Technology and Twin Pregnancy
- Hidradenitis Suppurativa and Treatments
- Prenatal Screening and Diagnostics
- Pharmaceutical Economics and Policy
- Insurance, Mortality, Demography, Risk Management
- Genital Health and Disease
- Reproductive tract infections research
- Animal Disease Management and Epidemiology
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Vaccine Coverage and Hesitancy
- Pharmaceutical studies and practices
- Fetal and Pediatric Neurological Disorders
Janssen (United States)
2017-2022
Harvard Global Health Institute
2015-2022
Third Affiliated Hospital of Guangzhou Medical University
2020-2021
Guangzhou Medical University
2020-2021
Guangzhou Institute of Dermatology
2020
Key Laboratory of Guangdong Province
2020
Guangzhou Women and Children Medical Center
2020
Harvard University
2014-2019
United Nations Department of Economic and Social Affairs
2018
Mount Sinai Beth Israel
2013
Although the beneficial effects of antiretroviral (ARV) therapy for preventing mother-to-child transmission are indisputable, studies in developed and developing countries have reported conflicting findings on association between ARV exposure adverse birth outcomes. We conducted a prospective observational study at 10 human immunodeficiency virus (HIV) care treatment centers Dar es Salaam, Tanzania. Multivariate log-binomial regression was used to investigate associations use outcomes among...
Background Home delivery and late infrequent attendance at antenatal care (ANC) are responsible for substantial avoidable maternal pediatric morbidity mortality in sub-Saharan Africa. This cluster-randomized trial aimed to determine the impact of a community health worker (CHW) intervention on proportion women who (i) visit ANC fewer than 4 times during their pregnancy (ii) deliver home. Methods findings As part 2-by-2 factorial design, we conducted home-based CHW 2 3 districts Dar es Salaam...
With the rapid rollout of antiretroviral therapy (ART) in sub-Saharan Africa (SSA), there has been an increasing concern about cardiovascular risks related to ART. However, data from human immunodeficiency virus (HIV)-infected populations this region are very limited.Among 6385 HIV-infected adults Dar es Salaam, Tanzania, we investigated nonfasting lipid changes over 3 years following ART initiation and their associations with different first-line agents that commonly used SSA.In first 6...
Background: Home visits by community health workers (CHW) could be effective in identifying pregnant women the before they have presented to system. CHW thus improve uptake of antenatal care (ANC), HIV testing, and prevention mother-to-child transmission (PMTCT) services. Methods: Over a 16-month period, we carried out quantitative evaluation performance reaching early pregnancy attended ANC Dar es Salaam, Tanzania. Results: As part intervention, 213 conducted more than 45,000 home about...
Background Enterovirus 71 (EV71) and coxsackievirus A16 (Cox A16) are major causative agents for hand, foot mouth disease (HFMD). Studies indicate that the frequent HFMD outbreaks result in a few hundreds children's death China recent years. The vaccine other research need to be developed urgently. aims of our study were: explore dynamic development mother-source neutralizing antibodies against EV71 Cox infants from Jiangsu Province, China, provide fundamental data further establishing...
Abstract Antenatal and post‐natal depression has demonstrated a significant burden in sub‐ S aharan A frica, with rates ranging from 10% to 35%. However, perinatal women living HIV T anzania have reported an even greater prevalence of (43–45%). The primary goal this study was examine the relationship between maternal infant malnutrition among . design retrospective cohort within context randomised controlled trial their infants. Within trial, 699 mother–child pairs were analysed for present...
To determine the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Tanzania, a cross-sectional study was conducted at HIV care treatment clinics. A Papanicolaou (Pap) smear used as screening tool for detection SIL. From December 2006 to August 2009, 1365 received screening. The median age 35 (interquartile range [IQR]: 30–42) years, CD4 + cell count 164 (IQR: 80–257) cells/mm 3 . SIL 8.7% (119/1365). In multivariate analysis, older (≥50...
Introduction NAMWEZA is a novel intervention that focuses on preventing HIV and promoting sexual reproductive health rights by addressing underlying factors related to vulnerability of acquiring HIV, such as depression, intimate partner violence (IPV) stigma. The goal the study was evaluate effect risk behaviour well potentially contributing this for people living with their network members. Methods A stepped-wedge randomised controlled trial conducted from November 2010 January 2014 among...
To explore the predictors of weight loss after highly active antiretroviral therapy (HAART) initiation in a large cohort HIV-infected adults living Dar es Salaam, Tanzania.Cross-sectional and longitudinal analysis on HAART.HIV-infected (n = 18 965) were enrolled between November 2004 to December 2009 Tanzania. Log-binomial regression Cox proportional hazard used short-term (3 months) long-term significant (≥ 5%) HAART initiation.At 3 months initiation, 8% patients lost greater than or equal...
The L1 cell adhesion molecule (L1CAM) gene, encodes the molecule, is involved in central nervous system development. Its mutations result syndrome which associated with brain malformation and developmental delay. We presented three fetuses hydrocephalus agenesis of corpus callosum detected by ultrasound, followed medical exome sequencing (MES) test L1CAM mutations: two known missense mutation c.551G > A (p. R184Q) c.1354G G452R), a novel frameshift c.1322delG causes early termination...
Psoriasis is a chronic autoimmune disease that associated with substantial economic burden related to work productivity loss (WPL). WPL commonly measured using the Work Productivity and Activity Impairment (WPAI) questionnaire. However, WPAI does not measure outcomes among unemployed patients, may therefore underestimate of psoriasis. This study evaluated relationship between Dermatology Life Quality Index (DLQI) questionnaire work/study domain WPAI, as DLQI assesses impact psoriasis on...
There is a dearth of evidence on the causal effects different care delivery approaches health system satisfaction. A better understanding public satisfaction with particularly important within context task shifting to community workers (CHWs). This paper determines CHW program focused maternal services among women who are pregnant or have recently delivered. From January 2013 April 2014, we carried out cluster-randomized controlled implementation trial program. Sixty wards in Dar es Salaam,...
Abstract The provision of high-quality antenatal care (ANC) is important for preventing maternal and newborn mortality morbidity, but only around half pregnant women in Tanzania attended four or more ANC visits 2019. Although there emerging evidence on the benefit community health worker (CHW) interventions uptake, few large-scale pragmatic trials have been conducted. This cluster-randomized trial, implemented directly through public sector system, assessed impact an intervention that...
Due to their contact with infected buffalo hide traders at Fort Clark on the Missouri River, about 60 miles north of present-day Bismarck, North Dakota, Mandan indigenous people suffered a large number deaths from smallpox in years 1837-40.In June 1837, St Peter, boat bearing traders, arrived Clark, and, despite efforts personnel American Fur Company keep Mandans away boat, majority tribe succumbed infection, only modest population 1600 surviving epidemic.The artist, Langdon Kihn, was born...
<h3>Background</h3> Rheumatoid arthritis (RA) is associated with impaired health-related quality of life (HRQoL). Sirukumab (SIR) an anti–interleukin-6 (IL-6) monoclonal antibody. <h3>Objectives</h3> These post hoc analyses evaluated improvements in HRQoL compared age/gender-matched normative population a phase 3 randomized, controlled trial SIR RA pts inadequate response to conventional disease-modifying antirheumatic drugs (DMARD-IR; SIRROUND-D). <h3>Methods</h3> 1670 received 50mg every 4...
<h3>Background</h3> Patients (pts) with rheumatoid arthritis (RA) experience reduced health-related quality of life (HRQoL). Sirukumab (SIR) is an anti–interleukin-6 (IL-6) monoclonal antibody. <h3>Objectives</h3> These post hoc analyses evaluated improvements over time in HRQoL relative to age/gender-matched normative population RA pts inadequate responses tumor necrosis factor inhibitors (TNF-IR) from the phase 3 SIRROUND-T trial. <h3>Methods</h3> 878 received SIR 50mg every 4 weeks (q4w),...
<h3>Background</h3> Sirukumab is an anti–interleukin-6 (IL-6) monoclonal antibody that selectively binds to the cytokine with high affinity and in development for rheumatoid arthritis (RA) other diseases. <h3>Objectives</h3> This study evaluated effects of sirukumab on work productivity/interference health status patients active RA despite treatment anti-tumor necrosis factor (TNF) therapy. <h3>Methods</h3> In this randomized, double-blind, phase 3 trial, 878 eligible who were...