A5114375546- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Health and Medical Research Impacts
- Acute Myocardial Infarction Research
- Healthcare professionals’ stress and burnout
- Diversity and Career in Medicine
- Diagnosis and Treatment of Venous Diseases
- Systemic Sclerosis and Related Diseases
- Pharmaceutical industry and healthcare
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Lipid metabolism and disorders
- Sex and Gender in Healthcare
- Central Venous Catheters and Hemodialysis
- COVID-19 and healthcare impacts
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Healthcare cost, quality, practices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related molecular mechanisms research
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical and Biological Sciences
Maastricht University
2021-2025
Post-thrombotic syndrome (PTS) is a heterogenous chronic condition that can develop after deep vein thrombosis (DVT) and diagnosed using the Villalta scale. This study applied unsupervised machine learning to investigate heterogeneity of PTS among patients within In 818 from IDEAL-DVT study, clustering identified four distinct clinical profiles: (1) younger with provoked DVT, (2) women joint pain, (3) men isolated popliteal (4) older diabetes femoral involvement. Clustering scale items...
The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: "coagulome" as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow, kidney. Four investigators shared their views these organ-specific topics. 2: Novel mechanisms thrombosis. Mechanisms linking factor XII fibrin, structural physical properties, contribute...
Deep vein thrombosis (DVT) is a multifactorial disease with several outcomes, but current classifications solely stratify it based on recurrence risk.We aimed to identify DVT phenotypes and assess their relation recurrent venous thromboembolism (VTE), postthrombotic syndrome, arterial events, cancer.Hierarchical clustering was performed cohort follow-up of up 5 years using 23 baseline characteristics. Phenotypes were summarized by discriminative Hazard ratios (HRs) calculated Cox regression;...
Background Residual venous obstruction (RVO) is considered a risk factor of recurrence and possibly other clinical outcomes following deep vein thrombosis (DVT). Current guidelines do not support an RVO-tailored duration anticoagulant therapy; contemporary data such management strategies are scarce. We aimed to evaluate RVO-based strategy assess associations RVO with recurrence, post-thrombotic syndrome (PTS), arterial events cancer. To gain further insight, D-dimer levels were measured 1...
BackgroundClinical management of patients with deep vein thrombosis (DVT) is centered around their risk recurrent venous thromboembolism (VTE) and post-thrombotic syndrome (PTS). While chronic inflammatory disease (CID) has been established as a factor (recurrent) VTE, research about its potential impact on PTS lacking.ObjectivesWe aimed to assess the in CID, stratifying for use anti-inflammatory treatment.Patients/MethodsConsecutive proximal DVT no active cancer between 2003 2018 received...
KEy WoRDsdeep vein thrombosis, post -thrombotic syndrome
Ultrasound-accelerated catheter-directed thrombolysis (UA-CDT) to improve patency after deep vein thrombosis (DVT) has not conclusively been shown prevent postthrombotic syndrome (PTS) but might benefit patients who are unlikely obtain with standard treatment. We hypothesized that these could be selected based on their fibrin clot properties. To study this, acute iliofemoral DVT from the CAVA (Ultrasound-Accelerated Catheter-Directed Thrombolysis Versus Anticoagulation for Prevention of...
Residual venous obstruction (RVO) after deep vein thrombosis (DVT) is considered a risk factor of recurrent thromboembolism (VTE), arterial events and post-thrombotic syndrome (PTS). We hypothesized thrombo-inflammatory markers might be associated with RVO clinical outcomes.In DVT cohort routine RVO-assessment 5-year follow-up, patients were invited for blood withdrawal stopping anticoagulants. Thrombin generation potential, coagulation enzyme:inhibitor complexes, soluble platelet measured...
Topic: 34. Thrombosis and vascular biology - Biology & Translational Research Background: Post-thrombotic syndrome (PTS) is a common complication of deep vein thrombosis (DVT). Inflammation known to play major pathogenic role in PTS, possibly by promoting residual venous obstruction (RVO). Nevertheless, the potential impact chronic inflammatory diseases (CIDs) their anti-inflammatory treatment on prevalence PTS has not been studied thus far. Aims: We assessed risk patients with CIDs,...
Topic: 34. Thrombosis and vascular biology - Biology & Translational Research Background: Catheter-directed thrombolysis (CDT) to improve patency after deep vein thrombosis (DVT) has not conclusively been shown prevent the post-thrombotic syndrome in randomized-controlled trials. However, additional CDT might benefit selected patients that are unlikely attain with standard treatment. Aims: We assessed whether fibrin clot properties associated long-term iliofemoral DVT. Methods: Patients...
Background: Incidence and long-term outcomes of cerebral venous sinus thrombosis (CVST) in the Asian population are still scarce.Aims: This study aimed to investigate incidence CVST Thai population, as well contributing factors, clinical presentation, outcomes.Methods: was a single-center, retrospective at universitybased-referral hospital Thailand.Consecutive patients who were diagnosed with between January 2010 December 2020 included.Results: There 107 median age 43.7 ± 20.4 years.The...