A5038042733- Hemophilia Treatment and Research
- Blood properties and coagulation
- Nutritional Studies and Diet
- Erythrocyte Function and Pathophysiology
- Blood Coagulation and Thrombosis Mechanisms
- Vitamin D Research Studies
- Obesity, Physical Activity, Diet
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Autophagy in Disease and Therapy
- Nutrition, Genetics, and Disease
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Liver physiology and pathology
- Consumer Attitudes and Food Labeling
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Diet and metabolism studies
- Transplantation: Methods and Outcomes
- Complement system in diseases
- Pericarditis and Cardiac Tamponade
- Telemedicine and Telehealth Implementation
- Dental Anxiety and Anesthesia Techniques
Copenhagen University Hospital
2014-2024
GW Medical Faculty Associates
2024
Milken Institute
2024
George Washington University
2024
Oslo University Hospital
2016-2023
Michigan State University
2023
Michigan United
2023
University of Oslo
1993-2019
Technical University of Denmark
2013-2017
National Research Centre for the Working Environment
2014
The lack of physiological parity between 2D cell culture and in vivo has led to the development more organotypic models, such as organoids. Organoid models have been developed for a number tissues, including liver. Current organoid protocols are characterized by reliance on extracellular matrices (ECMs), patterning culture, costly growth factors cellular diversity, structure, organization. hepatic generally simplistic composed hepatocytes or cholangiocytes, rendering them less...
Soluble circulating immunoglobulin G immune complexes are mainly eliminated by the liver, predominantly uptake in Kupffer cells, but also liver endothelial cells seem to be of importance. In present study we have followed intracellular turnover after Fc(gamma) receptor mediated endocytosis cultured rat and means isopycnic centrifugation, DAB cross-linking morphological techniques. For biochemical experiments antigen, dinitrophenylated bovine serum albumin (BSA), was labeled with...
ABSTRACT Introduction: There is a substantial body of evidence that obsessive-compulsive disorder (OCD) symptoms can be grouped into series discrete dimensions, and some not all OCD symptom dimensions respond equally well to pharmacologic or psychotherapeutic intervention. The response 12 weeks treatment with escitalopram placebo was investigated. Methods: Data from randomized, double-blind, placebo-controlled study in 466 adults were analyzed. Exploratory factor analysis individual items...
Dietary intake of vitamin D includes D3 (vitD3), 25-hydroxyvitamin (25OH-D3), and D2 (vitD2). However, the bioactivity different species has not been scientifically established. The hypothesis in this study was that vitD3, 25OH-D3, vitD2 have an equal effect on serum (vitamin status). To test our hypothesis, we performed a randomized, crossover study. Twelve young males consumed 10 µg/day vitD3 during four-week run-in period, followed by 3 × 6 weeks vitD2. content vitD2, (25OH-D2) quantified...
To determine the long-term risk of retinal detachment following pediatric cataract surgery and to identify factors for detachment.We included all children (aged 0 17 years) who during time period 1977 2005 underwent in Denmark, excluding cases caused by trauma, or acquired systemic ocular pathology, with anomalies associated development detachment. Cases were ascertained from mandatory Danish National Patient Register, information on was based medical chart review.Among 1043 eyes 656...
Bias in self-reported dietary intake is important when evaluating the effect of interventions, particularly for intervention foods. However, few have investigated this children, and none reporting accuracy fish children using biomarkers. In a Danish school meal study, 8- to 11-year-old ( n 834) were served New Nordic Diet (NND) lunch. The present study examined signature foods (berries, cabbage, root vegetables, legumes, herbs, potatoes, wild plants, mushrooms, nuts fish) characterising NND....
In 10 subjects, laser Doppler flowmetry was used to study whether cholinergic or β ‐adrenergic pathways are involved in the control of tooth pulp blood flow (PBF) response isometric hand grip and cold pressor test. We also examined if differences exist between regulation nearby gingiva (GBF). Isometric (35% maximum force, 2 min) subsequent ischaemia (2 induced a brief rise PBF more long‐lasting GBF. Atropine increased heart rate about by 40% changed pulpal fall flow, without altering...
Children with acute lymphoblastic leukemia (ALL) recive high doses of glucocorticosteroid as part their treatment. This may lead to suppression the hypothalamic-pituitary-adrenal axis, adrenal insufficiency, and ultimately life-threatening conditions. study explores function in 96 children ALL treated according common protocols. After cessation induction therapy, they received hydrocortisone substitution therapy (10 mg/m2/24 h) until an adrenocorticotropic hormone test (250 μg tetracosatide)...
Common genetic variants rs10741657 and rs10766197 in CYP2R1 rs4588 rs842999 GC a combined risk score (GRS) of these four influence late summer 25-hydroxyvitamin D (25(OH)D) concentrations. The objectives were to identify those who are most at developing low vitamin status during winter assess whether D3-fortified bread milk will increase 25(OH)D concentrations with genetically determined summer. We used data from the VitmaD study. Participants allocated either or non-fortified winter. In...
Early events during development leading to exit from a pluripotent state and commitment toward specific germ layer still need in depth understanding. Autophagy has been shown play crucial role both differentiation. This study employs human embryonic induced stem cells understand the early of lineage with respect autophagy this process. Our data indicate that dip facilitates pluripotency. Upon exit, we demonstrate modulation affects SOX2 levels commitment, induction promoting degradation...
Congenital coagulation factor (F) VII deficiency is a rare bleeding disorder caused by mutations in the F7 gene. The missense FVII variant p.Q160R disease-causing mutation all Norwegian deficient patients and results reduced biological activity antigen levels of patient plasma. Previous vitro studies on this demonstrated impaired intracellular trafficking secretion, possibly due to protein misfolding. aim study was therefore assess impact chemical chaperones cellular processing secretion...
A child's diet is an important determinant for later health, growth and development. In Denmark, most children in primary school bring their own packed lunch from home attend after-school care institution. The aim of the present study was to evaluate food, energy nutrient intake Danish relation dietary guidelines recommendations, assess food during outside hours. total, 834 nine public schools located eastern part Denmark were included this cross-sectional 798 (95·7 %) completed assessment...
ABSTRACT A lack of physiological parity between 2D cell culture and in vivo , has paved the way towards more organotypic models. Organoids exist for a number tissues, including liver. However, current approaches to generate hepatic organoids suffer drawbacks, reliance on extracellular matrices (ECM), requirement pattern culture, costly growth factors cellular diversity, structure organisation. Current organoid models are generally simplistic, composed hepatocytes or cholangiocytes, which...
The high proportion of people with HIV (PWH) in the 2022-2023 mpox outbreak has raised questions surrounding association between and mpox. objectives this study were to evaluate engagement HIV-associated healthcare diagnosis, as well characterize cases among PWH. DC Cohort is a longitudinal cohort PWH Washington, DC. We conducted 5:1 (controls:cases) nested case-cohort on male participants, matching age care site. Cases participants an identified diagnosis. Conditional logistic regression...
Abstract Laser Doppler flowmetry (LDF) was used to study the changes in pulpal blood flow (PBF) evoked by application of cold or heat palatinal surfaces teeth 11 21 nine young subjects. Switching from a thermode temperature 33° 5° G on average induced slow decrease PBF about 80% control, and also warming 39°C small reduction most Inter individual differences were large, however, both cooling sometimes triggered rise PBF. In contrast, skin flow, as recorded with LDF forearm, invariably rose...