A5071544706- Histone Deacetylase Inhibitors Research
- Colorectal Cancer Surgical Treatments
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- Phagocytosis and Immune Regulation
- Neuroscience and Neuropharmacology Research
- Cancer Mechanisms and Therapy
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Ubiquitin and proteasome pathways
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- NF-κB Signaling Pathways
- Cellular transport and secretion
- Stoma care and complications
- Colorectal Cancer Screening and Detection
- Pelvic floor disorders treatments
- Genetic factors in colorectal cancer
- Neurogenesis and neuroplasticity mechanisms
- Endoplasmic Reticulum Stress and Disease
- Frailty in Older Adults
- Lipid Membrane Structure and Behavior
- Advanced Breast Cancer Therapies
Saint John's Health Center
2014-2021
The University of Tokyo
2014-2021
Shizuoka University of Welfare
2021
Molecular Oncology (United States)
2014-2018
Kitasato University
2010-2016
Sanraku Hospital
2015
Tokyo Medical University
2014
Tokyo Institute of Technology
2014
// Katsuya Ohta 1 , Hiromitsu Hoshino Jinhua Wang Shigeshi Ono Yuuki Iida Keisuke Hata Sharon K. Huang Steven Colquhoun 2 and Dave S. B. Hoon Department of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA Liver Disease Transplant Cedars-Sinai Medical Beverly Hills, Correspondence: Hoon, email: Keywords : miR-93, hepatocellular carcinoma, drug-sensitivity, sorafenib tivantinib Received September 09, 2014 Accepted December 23,...
This study examined the role of ubiquitin E3-ligase RNF123 in modulating downstream NF-κB1 targets glioblastoma (GB) tumor progression. Our findings revealed an oncogenic pathway (miR-155-5p-RNF123-NF-κB1-p50-SerpinE1) that may represent a new therapeutic target for GB patients with isocitrate dehydrogenase 1 and 2 (IDH) WT (wild type). Mechanistically, we demonstrated is downregulated IDH leads to reduction p50 levels. RNA-sequencing, reverse-phase protein arrays, vitro functional assays on...
Purpose: Abnormal activation of the NF-κB pathway induces a more aggressive phenotype cutaneous melanoma. Understanding mechanisms involved in melanoma may identify novel targets for this pathway. KPC1, an E3 ubiquitin ligase, is regulator The objective study was to investigate regulating KPC1 expression and its clinical impact melanoma.Experimental Design: epigenetic regulation were assessed large cohorts clinically well-annotated tissues (tissue microarrays; n = 137, JWCI cohort; 40)...
Ectodysplasin (Eda) signaling is essential for the morphogenesis of several ectodermal appendages.Here, we report a medaka mutant, all-fin less (afl), which has nonsense mutation in its eda gene. The adult afl fish displayed various abnormalities dermal skeleton, such as short and twisted fin rays, missing abnormally shaped scales teeth, skull deformation. Focusing on developing rays caudal region larvae, found that did not elongate; although initial formation proceeded normally....
Primary mucosal melanoma (MM) is a rare subtype of that arises from melanocytes in the mucosa. MM has not been well profiled for mutations and its etiology understood, rendering current treatment strategies unsuccessful. Hence, we investigated mutational landscape to understand clarify are potentially relevant treatment. Forty one 48 cutaneous (CM) tissues were using targeted deep next-generation sequencing (NGS) 89 cancer-related genes. A total 997 within exons analyzed their spectrum...
Although CD133 is a representative cancer stem cell marker, its function in tumor aggressiveness under hypoxia remains unclear. Therefore, the present study aimed to investigate associations between CD133, epithelial-mesenchymal transition and distant metastasis colorectal cancer. CD133+ CD133- cells were isolated from single line LoVo, their adhesive migratory properties compared hypoxic conditions. Immunostaining analysis was performed determine expression clinical samples of primary...
Abstract Central venous port (CVP) is a widely used totally implantable access device. Recognition of risks associated with CVP-related complications clinically important for safe, reliable, and long-term intravenous access. We therefore investigated factors CVP infection evulsion, including the device type. A total 308 consecutive patients initial implantation between January 2011 December 2017 were retrospectively reviewed, association clinical features analyzed. Intraoperative...
The role of post-translational modifications (PTM) the key epigenetic factor DNMT1 protein has not been well explored in cutaneous metastatic melanoma progression. acetylated (ac-DNMT1) level was assessed using an anti-acetylated lysine antibody a clinically annotated patient tumor specimen cohort. In this study, we showed that surgically resected tumors have significantly higher expression (stage III metastasis n = 17, p 0.0009; stage IV 164, 0.003) compared to normal organ tissues (n 19)....
Systemic therapy can cause loss of skeletal muscle mass in colorectal cancer (CRC) patients the neoadjuvant and palliative settings. However, it is unknown how body composition changed by chemotherapy rendering unresectable CRC to resectable disease or affects prognosis. This study aimed at elucidating effects systemic on muscles survival stage IV who underwent conversion therapy.We reviewed 98 received our hospital. According treatment setting, were divided into conversion, (NAC),...
Background/Aims: Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis and handsewn for ulcerative colitis requires pulling down of the pouch into pelvis, which can be technically challenging. We examined risk factors not reaching anus.Methods: Clinical records 62 consecutive patients who were scheduled to undergo RPC at University Tokyo Hospital during 1989–2019 reviewed. Risk non-reaching analyzed in whom hand sewing was abandoned stapled because nonreaching. laparoscopic...
The Deloyers procedure is performed after extended left colectomy, enabling the reach of proximal colon to rectum for anastomosis while preserving sufficient blood supply. We report a case safely under indocyanine green (ICG) fluorescence guidance.
Background/Aim: It remains unclear whether rectal cancers down-staged by preoperative chemoradiotherapy (CRT) have similar prognoses to those of the same stage without CRT. We compared pT1 cancer patients stratified Patients and Methods: retrieved data with pathological T1 between 2003 2020. were divided into "ypT1 group" who received CRT following surgery "pT1 underwent alone. Factors associated relapse-free survival (RFS) investigated. Results: Among 86 patients, ypT1 groups comprised 18...
Abstract Background: Although the physiological functions of various phospholipases, such as lysophospholipase D (Autotaxin), has been extensively investigated, those Phosphatidylserine-Specific Phospholipase A1 (PSPLA1), a kind phospholipase involved in allergic reactions, not fully elucidated yet. Here, we evaluated role PSPLA1 oncogenesis and tumor metastasis colorectal cancer. Materials Methods: Surgical specimens 85 consecutive patients with cancer who received surgery our department...