A5068569188- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Schizophrenia research and treatment
- Esophageal and GI Pathology
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Cancer Cells and Metastasis
- Functional Brain Connectivity Studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Electroconvulsive Therapy Studies
- Colorectal and Anal Carcinomas
- Heart Rate Variability and Autonomic Control
- Reading and Literacy Development
- Neurobiology of Language and Bilingualism
- Biliary and Gastrointestinal Fistulas
- Diverticular Disease and Complications
- Epilepsy research and treatment
- Pluripotent Stem Cells Research
- Hearing Loss and Rehabilitation
Tokyo Medical and Dental University
2011-2023
Osaka City General Hospital
2016-2023
Kindai University
2020-2022
Tokyo Metropolitan Tama Medical Center
2022
Nara Medical University Hospital
2020
Special Service for Groups
2020
Higashi Osaka City General Hospital
2015-2018
Osaka University
2011-2016
American Gastroenterological Association
2016
Saint John's Health Center
2013-2014
// Katsuya Ohta 1 , Hiromitsu Hoshino Jinhua Wang Shigeshi Ono Yuuki Iida Keisuke Hata Sharon K. Huang Steven Colquhoun 2 and Dave S. B. Hoon Department of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA Liver Disease Transplant Cedars-Sinai Medical Beverly Hills, Correspondence: Hoon, email: Keywords : miR-93, hepatocellular carcinoma, drug-sensitivity, sorafenib tivantinib Received September 09, 2014 Accepted December 23,...
Objective: The present study proposes a new epileptic seizure prediction method through integrating heart rate variability (HRV) analysis and an anomaly monitoring technique. Methods: Because excessive neuronal activities in the preictal period of epilepsy affect autonomic nervous systems function affects HRV, it is assumed that can be predicted HRV. In proposed method, eight HRV features are monitored for predicting seizures by using multivariate statistical process control, which...
Cancer stem cells (CSCs) are known to influence chemoresistance, survival, relapse and metastasis. Aldehyde dehydrogenase (ALDH) functions as an epithelial CSC marker. In the present study, we investigated involvement of ALDH in gastric maintenance, chemoresistance survival. Following screening for eight candidate markers (CD13, CD26, CD44, CD90, CD117, CD133, EpCAM ALDH), five cancer cell lines were found contain small subpopulations high activity (ALDHhigh cells). We also examined ALDHhigh...
Exploratory eye movements in schizophrenic and nonschizophrenic subjects were examined with an mark recorder while the viewed geometric figures. Elementary components of responsive search score (RSS), a function number sections on which fixated, measured by means movement analyzer slow motion replay. The group depressed patient had fewer fixations than normal control obsessive-compulsive disorder group. lower RSS average patients depression, disorders, or These results conjunction those our...
The global incidence of colorectal cancer (CRC) is increasing. Although there are emerging epigenetic factors that contribute to the occurrence, development and metastasis CRC, biological significance molecular regulation in different subpopulations such as stem cells remains be elucidated. In this study, we investigated functional roles H3K4 demethylase, jumonji, AT rich interactive domain 1B (JARID1B), an factor required for continuous cell growth melanomas, CRC. We found CD44(+)/aldehyde...
Cancer stem cells (CSCs) also known as cancer-initiating (CICs) show high tumorigenic activity and chemo- radiation resistance. It is, therefore, important to identify CSCs reliably develop novel curative cancer treatments. In this study, we re-evaluated CSC markers of colorectal for their cellular differentiation activity, with the aim reliable markers. The rates change in CD44, CD133, CD166, CD24, CD49f CXCR4 expression during sodium butyrate (NaBT)-induced cell were assessed HT29 Caco2...
Although esophageal cancer is highly heterogeneous and the involvement of epigenetic regulation stem cells suspected, biological significance epigenetically modified molecules that regulate different subpopulations remains to be firmly established. Using cells, we investigated functional roles H3K4 demethylase Jumonji/Arid1b (Jarid1b) (Kdm5b/Plu‑1/Rbp2‑h1), an factor required for continuous cell growth in melanoma. JARID1B knockdown resulted suppression growth, sphere formation invasion...
Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a target of Wnt signalling and considered both cancer stem cell marker intestinal marker. We found first some splice variants LGR5 in human intestine elucidated the functional feature full-length (LGR5FL). Reverse transcript PCR using mRNA extracted from revealed existence variants. designed an antibody that recognises only LGR5FL assessed immunohistochemically distribution LGR5FL-positive cells Ki-67-positive clinical...
In order to clarify the feature of attention disorders in schizophrenia, two tasks (X and AX) Continuous Performance Test (CPT) were given 36 schizophrenic patients 25 healthy controls. The performed considerably less well than normal Performances expressed indices such as omission commission errors, reaction time discriminability. Among both X AX was found be an index that varied time, indicating difficulty sustaining attention. Omission act a state-dependent schizophrenia relation...
Abstract Regorafenib has shown significant survival benefit as a salvage therapy for colorectal cancer; however, its starting dose been controversial in recent studies. Therefore, we conducted prospective study on the efficacy and safety of reduction regorafenib to 120 mg. Patients received mg once per day 3 weeks, followed by 1-week off-treatment period. The primary endpoint was investigator-assessed disease control rate (DCR). Sixty patients were registered, DCR 38.3% with median...
Regenerating gene 1A (REG1A) plays an important role in tissue regeneration and cell proliferation epithelium origin tumors; however, its melanoma has not been explored details. The objective of this study was to identify whether REG1A is expressed cutaneous if expression status can predict prognosis patients with metastasis. We also determined epigenetic regulation the promoter region regulates expression. AJCC stage III specimens clinically well annotated lymph node metastasis microarray...