A5101748146- Pulmonary Hypertension Research and Treatments
- Organometallic Complex Synthesis and Catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Coordination Chemistry and Organometallics
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Congenital Heart Disease Studies
- Blood Pressure and Hypertension Studies
- Recycling and utilization of industrial and municipal waste in materials production
- Lung Cancer Research Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Renal function and acid-base balance
- Boron Compounds in Chemistry
- Heart Rate Variability and Autonomic Control
- Congenital heart defects research
- Medicinal Plant Pharmacodynamics Research
- High Altitude and Hypoxia
- Cardiovascular Issues in Pregnancy
- Cancer Mechanisms and Therapy
- Potassium and Related Disorders
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Lung Cancer Treatments and Mutations
- Menopause: Health Impacts and Treatments
Second Xiangya Hospital of Central South University
2023-2025
Central South University
2023-2025
First Affiliated Hospital of Xiamen University
2025
Xiamen University
2025
Shaoxing University
2022
Zhejiang University
2017-2018
Sichuan Provincial Hospital of Traditional Chinese Medicine
2015
Wuhan Institute of Bioengineering
2009
Chinese University of Hong Kong
1996-2000
Radiofrequency ablation (RFA) has been a central therapeutic strategy for ventricular tachycardia (VT). However, concerns about its long-term effectiveness and complications have arisen. Pulse field (PFA), characterized by nonthermal, highly tissue-selective technique, emerged as promising alternative. This comprehensive review delves into the potential advantages opportunities presented PFA in realm of VT, drawing insights from both animal experimentation clinical case studies. shows...
The relationship between anion gap (AG) and short-term mortality of pulmonary hypertension (PH) patients with sepsis in the intensive care unit (ICU) remains unclear. This study involved a retrospective analysis incident PH first admitted to ICU MIMIC IV database (2008 2019). Short-term outcomes include in-hospital 28-day mortality. According AG value (17.0 mmol/L), were divided into high-AG low-AG groups. Kaplan-Meier survival curve was used compare cumulative rates high low groups using...
Malnutrition presents a significant challenge in managing patients with atrial fibrillation (AF) and heart failure preserved ejection fraction (HFpEF), yet its impact on AF recurrence after catheter ablation this population remains unclear. We conducted retrospective analysis of 204 paroxysmal non-valvular HFpEF who underwent radiofrequency or cryoballoon ablation. Risk malnutrition as assessed using three screening tools: the Controlling Nutritional Status (CONUT) score, Prognostic Index...
To compare the efficacy of crizotinib, pemetrexed and other chemotherapy regimens as a first-line treatment in patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) real world clinical use to evaluate +86–571-87,236,876 predictive factors crizotinib. The 73 ALK-positive advanced NSCLC were divided into three groups based on treatment: crizotinib group (1-CRZ group, n = 32); platinum-based (1-PP 28), non-pemetrexed (N1-PP, 12). Sixty eight received...
Resistance to epidermal growth factor receptor (EGFR) inhibitors is of primary concern in the treatment non‑small‑cell lung cancer (NSCLC) with EGFR mutations. To investigate effects matrine on H1975 cells and examine a novel, potential option for NSCLC, present study measured cell viability, apoptotic rate, interleukin 6 (IL‑6) expression activation janus kinase (JAK) 1/signal transducer activator transcription (STAT)3 signaling pathway treated or without matrine, presence absence afatinib....
The delayed titration of guideline-directed drug therapy (GDMT) is a complex event influenced by multiple factors that often result in poor prognosis for patients with heart failure (HF). Individualized adjustments GDMT may be necessary based on patient characteristics, and every clinician responsible promptly initiating titrating it appropriately within the patient's tolerance range. This review examines current challenges implementation scrutinizes considerations distinct subsets HF...
The crystal structures of several phosphine oxide and dimethyl sulphoxide complexes indium trihalides have been determined. compounds [InCl3(Me3PO)2(MeOH)], [InCl3-(Me3PO)2(H2O)]·H2O, [InCl3(PhMe2PO)3]·H2O, [InCl3(Me2SO)3], [InBr3(Me2SO)3] are all fac octahedral, but [InCl3(Me3PO)3] has the mer configuration. Triphenylphosphine yields ionic derivatives type [InX2(Ph3PO)4]+[InX4]–(X = Cl or Br). Methyldiphenylphosphine gives covalent [InCl3(Ph2MePO)3], [InBr2(Ph2MePO)4]+[InBr4]–. general...
The mechanism of pulmonary arterial hypertension (PAH) after surgery/intervention for isolated venticlular septal defect (VSD) in children is unknown. Reliable prognostic indicators predicting postoperative PAH are urgently needed. Prognostic nutration index (PNI) widely used to predict complications and survival adults, but it unclear whether can be as an indicator prognosis children.
Treatment of [MO2Cl2·(DME)] (M = Mo, W; DME 1,2-dimethoxyethane) with the lithium reagents LiLn [L1 −N(SiMe3)(2-C5H3N-6-Me), L2 −N(SiButMe2)(2-C5H3N-6-Me), L3 −N(SiButPh2)(2-C5H3N-6-Me)] afforded corresponding cis-dioxo-Mo(VI) amido complexes [MoO2(Ln)2] (Ln L11, Ln L22, L33) and cis-dioxo-W(VI) [WO2(Ln)2] L14, L25, L36). X-Ray crystallography shows that compounds 1, 2, 4 5 are mononuclear ligands bound to metal centres in a N,N-chelating fashion forming highly strained four-membered...
The reaction of SnCl2 with [LiRN(tmeda)]2 [RN = CH(SiButMe2)C5H4N-2; tmeda N,N,N',N'-tetramethylethylenediamine)] in various stoichiometric ratios afforded a binuclear chlorotin(II) alkyl [Sn(Cl)RN]2 (1) and zwitterionic lithium trialkylstannate complexes [{(SnRN3)Li}{(μ3-Cl){Li(tmeda)2}(μ2-Cl)] (2) [{(SnRN3)Li}(μ3-Cl)Li(tmeda)]2 (3). X-ray structure analysis has shown that the anionic N-functionalized ligand (RN)- 1 acts as bridging joining two tin atoms to form an eight-membered ring...
Pulmonary arterial hypertension (PAH) is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load, posing significant threat to patient health. While some pathological mechanisms of PAH have been revealed, the deeper pathogenesis remain be elucidated. In recent years, bioinformatics has provided powerful tool for understanding complex through integration techniques such as multi-omics analysis, artificial intelligence, Mendelian...
Background: Acquired mitochondrial dysfunction is one of the characteristics pulmonary arterial hypertension (PAH). Exploring potential biomarkers from perspective may be effective in diagnosis and treatment PAH. We aimed to screen for mitochondria-related biomarker(s) associated with PAH using integrated bioinformatics approach machine learning algorithms. Methods: On basis gene expression profiles healthy samples GEO database, hub differentially expressed genes were identified Integrated...
Background: The relationship between anion gap (AG) and short-term mortality in intensive care unit (ICU) sepsis patients complicated by pulmonary hypertension (PH) remains unclear. Methods: Retrospective analysis of incident PH first admitted to ICU MIMIC database (2008 2019) were enrolled. Short-term outcomes include in-hospital 28-day mortality. According the AG value (17.0 mmol/L), divided into high low groups. Kaplan-Meier survival curve was used compare cumulative rates groups using...
Background:The efficacy of radiofrequency ablation (RFA) in patients with atrial fibrillation (AF) and heart failure preserved ejection fraction (HFpEF) has been established, but the safety cryoballoon (CBA) pulsed field (PFA) remain unclear.Methods: This retrospective cohort study included 223 paroxysmal non-valvular AF HFpEF who underwent their first between January 2017 December 2021 were divided into RFA (n = 77), CBA 127), PFA 19) groups.Results: After a mean follow-up 11.2 ± 1.8...
Metalation of 3,3'-dimethyl-2,2'-bipyridine and its trimethylsilyl derivatives (2-RCH2C5H3N)2 (R = H, SiMe3) using appropriate stoichiometries BunLi/tmeda yields the corresponding mono- dilithiated compounds. Deprotonation was found to occur selectively at α-methyl carbon, as established by quenching lithiated compounds with Me3SiCl or D2O analyzing products NMR spectroscopy. The C2 molecular structure dilithium compound [{2-CH(SiMe3)C5H3N}2{Li(tmeda)}2] (2a) has been determined X-ray...