A5035615589- Veterinary Oncology Research
- Microbial infections and disease research
- Infectious Diseases and Mycology
- Cervical Cancer and HPV Research
- AI in cancer detection
- Cancer and Skin Lesions
- Clinical Laboratory Practices and Quality Control
- Animal health and immunology
- Veterinary Equine Medical Research
- Virus-based gene therapy research
- Blood groups and transfusion
- Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Animal Virus Infections Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Reproductive Physiology in Livestock
- Scientific Computing and Data Management
- Medical Imaging and Pathology Studies
- Platelet Disorders and Treatments
- Hemodynamic Monitoring and Therapy
- Bird parasitology and diseases
- Veterinary Practice and Education Studies
- Reliability and Agreement in Measurement
Coventry (United Kingdom)
2018-2024
University of Warwick Science Park
2007-2022
University of Warwick
2021
Animal Health Trust
2014-2020
University of Cambridge
2013-2019
Farm Africa
2017
Summary The diagnosis of respiratory diseases in horses can be difficult due to the nonspecific nature clinical signs, which overlap between different diseases. Cytological examination secretions is a helpful diagnostic tool that, when combined with features and other techniques, has potential improve accuracy significantly. This review article should help readers become familiar cytology normal tract cytopathological abnormalities associated common disorders horses.
To evaluate the efficiency of platelet-rich plasma preparations by means a double centrifugation tube method to obtain canine at concentration least 4 times higher than baseline value and white blood cells not exceeding twice reference range. A complete count was carried out for each sample concentrate. Whole samples were collected from 12 clinically healthy dogs (consenting donors). Blood processed platelet concentrates, which then analyzed flow cytometry haematology system haemogram....
A 16-year-old, Irish Draft mare was admitted to the referring veterinarian for an annual health check. mild generalized lymphadenomegaly noted. Rectal palpation and transrectal ultrasonographic examination revealed prominent mesenteric lymph nodes. transcutaneous abdominal evaluation unremarkable. CBC a marked leukocytosis (63.06 × 10(3)/μL) lymphocytosis (58.2 due increased numbers of small lymphocytes. No evidence anemia or thrombocytopenia found neutrophil counts were low-normal....
A 4-month-old female entire domestic shorthair cat presented with an acute onset of blindness, tetraparesis and subsequent generalised seizure activity. Haematology serum biochemistry demonstrated a moderate, poorly regenerative anaemia, hypoalbuminaemia hyperglobulinaemia low albumin:globulin ratio. Serology for feline coronavirus antibody was positive elevated alpha-1 acid glycoprotein. Analysis cisternal cerebrospinal fluid (CSF) markedly protein mixed, predominately neutrophilic...
Flow cytometric immunophenotyping is a useful step in the diagnosis of lymphoproliferative malignancies human and veterinary medicine. The purpose this study was to assess usefulness technique for disorders cats. Nineteen cats were retrospectively enrolled allocated into two groups. Group 1 consisted 13 with lymphoma, whereas group 2 6 non-neoplastic disorders. Fine-needle aspiration biopsies analysed by flow cytometry order evaluate immunophenotype. analysis identified neoplastic lymphoid...
An asymptomatic macrothrombocytopenia, phenotypically similar to inherited macrothrombocytopenia in Cavalier King Charles Spaniels, was described a group of Norfolk Terriers (NT) from Northern Italy, and isolated cases were also reported Cairn (CT).The purpose this work evaluate for the presence genetic defect β1-tubulin gene macrothrombocytopenic NT CT.Samples 20 healthy dogs (13 7 CT) collected at different institutions Italy (n = 8), United Kingdom 3), States 9). Genomic DNA harvested...
Abstract A 2‐year and 6‐month‐old female neutered Labrador Retriever with Horner syndrome, megaesophagus, a mediastinal mass was referred to the Queen Mother Hospital for Animals of Royal Veterinary College. large granular lymphocyte ( LGL ) lymphoma diagnosed on cytology; flow cytometric analysis revealed γδ T‐cell phenotype CD 3+, 5+, 45+, TCR γδ+, 4−, 8−, 34−, 21−). Chemotherapy started combination lomustine, vincristine, procarbazine, prednisolone, followed by bleyomicin. Euthanasia...
Digital slides created by whole-slide imaging scanners can be evaluated pathologists located in remote sites, but the process must validated before this technology applied to routine cytological diagnosis. The aim of study was validate a scanner for samples. Sixty samples, whose diagnoses were confirmed gold-standard examinations (histology or flow cytometry), digitalized using scanner. and glass examined 3 observers with different levels cytopathological expertise. No significant...
Background Quality control ( QC ) validation is an essential tool in total quality management of a veterinary clinical pathology laboratory. Cost‐analysis can be valuable technique to help identify appropriate procedure for the laboratory, although this has never been reported medicine. Objective The aim study was determine applicability Six Sigma Cost Worksheets evaluation possible candidate rules identified by validation. Methods Three months internal records were analyzed. EZ Rules 3...
Flow cytometric analysis of blood samples for immunophenotyping lymphoproliferative diseases has become popular in veterinary medicine. Unfortunately, the use this technique been limited by necessity to test within a short time frame after collection. A possible solution problem is fixative products preserve stability lymphoid antigens.The aim study was evaluate expression 5 surface markers (CD3, CD4, CD8, CD21, and CD45) collected K3-EDTA Cyto-Chex BCT tubes from healthy dogs.Blood 8 dogs...
Tumours shows aberrant DNA methylation patterns, being hypermethylated or hypomethylated compared with normal tissues. In human acute myeloid leukaemia (hAML) mutations in methyltransferase (DNMT3A) are associated to a more aggressive tumour behaviour. As AML is lethal dogs, we defined global content, and screened the C-terminal domain of DNMT3 family genes for sequence variants 39 canine (cAML) cases. A heterogeneous pattern was found among cAML samples, subsets cases healthy controls; four...
Cytopathology is a minimally invasive and convenient diagnostic procedure, often used as substitute for histopathology to diagnose characterize lymphoma in dogs. Assess the performance of cytopathology diagnosing its histopathological subtypes One-hundred sixty-one lymph node samples from 139 dogs with enlarged peripheral nodes. Based only on cytopathology, 6 examiners independently provided following interpretations each sample: (a) vs nonlymphoma; (b) grade phenotype; (c) World Health...
Vaginal and vulvar tumors are uncommon in dogs. Knowledge of canine primary clitoral neoplasia is restricted to a few case reports, only carcinomas have been reported. Cytologic histologic features reported the literature seem overlap with those apocrine gland anal sac adenocarcinoma (AGASA). Clinical also recall AGASA, such as locoregional metastases hypercalcemia malignancy (HM). In this study, 6 cases (CCCs), without HM, were investigated by means cytology, histopathology, electron...
Abstract Cancer is a major reason for veterinary consultation, especially in companion animals. surveillance plays key role prevention but opportunities such animals are limited by the lack of suitable population health infrastructures. In this paper we describe pathology-based animal tumour registry (PTR) developed within Small Animal Veterinary Surveillance Network (SAVSNET) built from electronic pathology records (EPR) submitted to network. From an original collection 180232 free text...
A nine–year‐old female neutered Somali cat presented with a one‐month history of weight loss and inappetance. Thoracic radiographs revealed an extensive cranial mediastinal mass, fine needle aspirate cytology core biopsies were initially suggestive thymoma. The mass was excised via mid‐ine sternotomy partial pericardectomy. Clinical signs recurred four weeks postsurgery investigations recurrence pleural effusion additional small to the right kidney. Histopathological examination...
Abstract A 12‐year‐old British Warmblood mare was examined by the referring veterinarian for evaluation of a cutaneous lesion on dorsal thorax to right midline. Cytologic examination fine‐needle aspirates from mass supportive giant cell tumor soft parts ( GCTSP ). Laser surgical excision and postoperative methyl aminolevulinate MAL ) photodynamic therapy PDT were performed. Histologic confirmed cytologic diagnosis. At 8 months surgery, no evidence recurrence has been observed. Giant tumors...
Respiratory disease is a common cause for presentation of working horses to clinics in Ethiopia and priority concern owners.To identify risk factors association pathogens with respiratory signs horses.Unmatched case-control study.Cases were those animals recently coughing (last 7 days) or observed coughing, nasal discharge altered respiration at the time examination. A physical exam endoscopy performed including tracheal wash sample detect presence serology on blood. An owner questionnaire...
Abstract This month, Francesco Cian of Batt Laboratories presents a haematology case cat with marked anaemia.
The COVID-19 pandemic accelerated technological changes in veterinary education, particularly clinical pathology and anatomic courses transitioning from traditional methods to digital (DP). This study evaluates the personal effectiveness satisfaction, as well advantages disadvantages, of DP, particular cytology (DC), a teaching method among European students, both at undergraduate postgraduate level, who attended during before pandemic. A further aim is discuss differences between two...
The authors declare that they have no conflict of interest.
Abstract This month Francesco Cian of Batt Laboratories presents a clinical case where cytology was crucial to achieve definitive diagnosis.