A5105267170- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Renal Transplantation Outcomes and Treatments
- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Organ Transplantation Techniques and Outcomes
- Dementia and Cognitive Impairment Research
- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Electrolyte and hormonal disorders
- Potassium and Related Disorders
- Cardiac electrophysiology and arrhythmias
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Frailty in Older Adults
- Biochemical and Molecular Research
University of Louisville
2022-2024
East Tennessee State University
2024
NewGen Therapeutics (United States)
2023
Amgen (United States)
2022
The University of Texas Southwestern Medical Center
2021
VA Boston Healthcare System
2020
University of Cambridge
2010-2018
Massachusetts General Hospital
2006-2016
Harvard University
1984-2015
Harvard University Press
2015
Intensive remote monitoring programs for congestive heart failure have been successful in reducing costly readmissions, but may not be appropriate all patients. There is an opportunity to leverage the increasing accessibility of mobile technologies and consumer-facing digital devices empower patients their own health outside hospital setting. The iGetBetter system, a secure Web- telephone-based program, which leverages technology portable devices, offers creative solution at lower cost.The...
Background: Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms exercise-mediated health benefits remain less clear. We used metabolite profiling before after acute to delineate the metabolic architecture response patterns in humans. Methods: Cardiopulmonary testing was performed on Framingham Heart Study participants (age 53±8 years, 63% women) blood drawn at rest (n=471) peak (n=411). Results: observed changes circulating levels for...
Patients with light chain (AL) amyloidosis who present severe heart failure due to cardiac involvement rarely survive more than 6 months. Survival after transplantation is markedly reduced the progression of amyloidosis. Autologous stem-cell (ASCT) has become a common therapy for AL amyloidosis, but there an exceedingly high treatment-related mortality in patients failure.We developed treatment strategy transplant followed by ASCT. Twenty-six were evaluated, and 18 eligible patients, nine...
The European Prospective Investigation of Cancer (EPIC) is a 10-country collaborative study in which EPIC-Norfolk one the UK centres. examined 25 639 men and women resident East Anglia (aged 40–79 years), between 1993 1997. EPIC collaboration was set up to examine dietary determinants cancer, but remit cohort broadened from outset include other health conditions chronic diseases. completed third round examinations (EPIC-Norfolk 3 or 3HC) December 2011, on 8623 participants age range 48–92...
Ventilatory efficiency (minute ventilation required to eliminate carbon dioxide, VE/VCO2) during exercise potently predicts outcomes in advanced heart failure with reduced ejection fraction, but its prognostic significance for at-risk individuals preserved left ventricular systolic function is unclear. We aimed characterize mechanistic determinants and implications of VE/VCO2 a single-center dyspneic referral cohort (MGH-ExS [Massachusetts General Hospital Exercise Study]) large sample...
Hyponatremia is a well-known predictor of mortality in patients with acutely decompensated heart failure. Associations between hyponatremia and other prognostic variables failure, such as amino-terminal pro-B type natriuretic peptide remain unclear.Six hundred twenty-eight presenting to the emergency department failure were studied. All hospitalized. Serum sodium (Na) concentration at presentation was examined function 1 year, alone relative predictors death. (Na < or =135 mmol/L) diagnosed...
Despite several studies demonstrating an independent and inverse association between cognition mortality, the nature of this still remains unclear. To examine mortality after accounting for sociodemographic, health lifestyle factors to explore both test population characteristics influencing relationship. In a based cohort 8585 men women aged 48–92 years, who had cognitive assessments in 2006–2011 were followed up till 2016 we examined relationship individual tests as well global score...
Many proven heart failure (HF) therapies decrease N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) values over time, yet some patients have an NT‐proBNP >1000 pg/ mL following treatment, which is associated with poor outcomes. A total of 151 left ventricular systolic dysfunction were treated aggressive HF therapy in the ProBNP Outpatient Tailored Chronic Heart Failure (PROTECT) study. Clinical characteristics and measured at each visit during 10 months. In this post hoc analysis,...
Given the magnitude of increasing heart failure mortality, multidisciplinary approaches, in form disease management programs and other integrative models care, are recommended to optimize treatment outcomes. Remote monitoring, either as structured telephone support or telemonitoring a combination both, is fast becoming an integral part many programs. However, studies reporting on evaluation real-world remote monitoring scarce.This study aims evaluate effect program, Connected Cardiac Care...