A5101807318- Food Allergy and Anaphylaxis Research
- Airway Management and Intubation Techniques
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Phylogenetic Studies
- Tracheal and airway disorders
- Chemical Synthesis and Analysis
- Protein Hydrolysis and Bioactive Peptides
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Click Chemistry and Applications
- Food Safety and Hygiene
- Cancer Treatment and Pharmacology
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- Probiotics and Fermented Foods
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Caveolin-1 and cellular processes
- Otolaryngology and Infectious Diseases
- Ion channel regulation and function
- Tuberous Sclerosis Complex Research
- Anorectal Disease Treatments and Outcomes
- Advanced Drug Delivery Systems
- Head and Neck Anomalies
- Inhalation and Respiratory Drug Delivery
Northwestern University
2024
Lurie Children's Hospital
2024
Rice University
2019-2022
Mayo Clinic in Florida
2022
University of Windsor
2019
La Trobe University
2017
Department of Medical Sciences
2015
University of Miami Hospital
2014
University of Delhi
2011-2014
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
2001-2009
Site-specific introduction of bioorthogonal handles into biomolecules provides powerful tools for studying and manipulating the structures functions proteins. Recent advances in chemistry demonstrate that tetrazine-based cycloaddition is a particularly useful methodology due to its high reactivity, biological selectivity, turn-on property fluorescence imaging. Despite broad applications protein labeling imaging, utilization has been limited date by requirement hydrophobic strained alkene...
Women older than 70 years have been underrepresented in breast cancer adjuvant chemotherapy trials due to concerns about toxicity, safety and tolerance of chemotherapy. The aim our study was assess the women with determine patterns toxicity including impact age, regimen, functional status comorbid conditions on this toxicity. We retrospectively reviewed charts early stage (stages 1 2) patients from 1998 2004. A total 62 patients, mean age 74.3 years, were identified. Chemotherapy completed...
Systemic administration of bio-therapeutics can result in only a fraction drug reaching targeted tissues, with the majority being distributed to tissues irrelevant drug's site action. Targeted delivery specific organs may allow for greater accumulation, better efficacy, and improved safety. We investigated how targeting plasmalemma vesicle-associated protein (PV1), found endothelial caveolae lungs kidneys, promote accumulation these organs. Using ex vivo fluorescence imaging, we show that...
IgG antibodies are abundantly present in the vasculature but to a much lesser extent mucosal tissues. This contrasts with of IgA and IgM isotype that at high concentration secretions due active delivery by polymeric Ig receptor (pIgR). is preferred for therapeutic mAb development its long serum half-life robust Fc-mediated effector function, it utilized treat diverse array diseases antigen targets located vasculature, serosa, mucosa. As targeting luminal side tissue lack an transport...
Despite the rapid evolution of therapeutic antibodies, their clinical efficacy in treatment bone tumors is hampered due to inadequate pharmacokinetics and poor tissue accessibility these large macromolecules. Here, we show that engineering antibodies with bone-homing peptide sequences dramatically enhances concentrations metastatic niche, resulting significantly reduced survival progression breast cancer metastases. To enhance tumor-targeting ability engineered introduced varying numbers...
Background: Hospital risk stratification models using electronic health records (EHRs) often use age and comorbid burden. Our primary aim was to determine if quality of life or behaviors captured in an EHR-linked biobank can predict future hospitalization. Methods: Participants the Mayo Clinic Biobank completed self-administered questionnaires at enrollment that included behaviors. enrolled as December 31, 2010 were followed for one year ascertain Data on comorbidities hospitalization...
Agrobacterium tumefaciens is a Gram-negative bacterium and causative agent of Crown Gall disease that infects variety economically important plants. The annotated A. genome contains 10 putative dapA genes, which code for dihydrodipicolinate synthase (DHDPS). However, we have recently demonstrated only one these genes (dapA7) encodes functional DHDPS. function the other nine yet to be determined. Here, demonstrate using bioinformatics product dapA5 gene (DapA5) possesses all catalytic...
Soft tissue involvement is an unusual presenting feature for children with meningococcal infection. We describe 2 children, 1 conjunctivitis and another a thyroglossal duct cyst abscess associated Neisseria meningitidis, review previous reports of these entities to emphasize the broad spectrum disease pertinent aspects treatment prophylaxis contacts.
We report here a case of cystic lymphangioma scrotum presenting as acute due to haemorrhage. The diagnosis was confirmed on ultrasonography and magnetic resonance imaging managed successfully by surgical excision. There past history bilateral congenital cataract for which the patient had undergone surgery with complete visual recovery. Scrotal complicated haemorrhage is rare; hence, being reported review literature.
Abstract GA 2 LEN and EFA propose minimum specifications for all industrialised countries/regions to work towards support students with food allergies in educational settings. We reviewed research legislation gained feedback from over 100 patient professional groups. built shared expectations around: 1. training school staff about what allergy is, the symptoms of allergic reactions, do an emergency, when how use store devices that laypeople can administer adrenaline (epinephrine). 2....
15123 Background: Though pancreatic cancer ranks eighth among all major forms of related deaths, it accounts for only 3% cancers worldwide. Diabetes mellitus type 2 and are known to be associated but this relationship decreases inversely with an increasing duration diabetes. The aim the present study is assess whether new onset diabetes a risk factor or results as outcome cancer. Methods: We conducted meta-analysis available studies examine association. Using PUBMED, EMBASE & MEDLINE we...