A5100608509- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Microbial infections and disease research
- Monoclonal and Polyclonal Antibodies Research
- Emotional Intelligence and Performance
- Blood Pressure and Hypertension Studies
- Curcumin's Biomedical Applications
- Child Nutrition and Water Access
- Infant Nutrition and Health
- Pomegranate: compositions and health benefits
- Renal and Vascular Pathologies
- Banana Cultivation and Research
- Food Science and Nutritional Studies
- Cancer Genomics and Diagnostics
- Health, psychology, and well-being
- Breastfeeding Practices and Influences
- Fungal Biology and Applications
- Heavy Metal Exposure and Toxicity
- Orthopedic Infections and Treatments
- Tryptophan and brain disorders
- Sodium Intake and Health
- Gas Sensing Nanomaterials and Sensors
- Cancer Cells and Metastasis
- Higher Education and Employability
- Gastrointestinal disorders and treatments
Panjab University
2012-2024
Public Works Department Buildings and Roads
2024
Post Graduate Institute of Medical Education and Research
2024
University of Calgary
2020-2024
Guru Gobind Singh Medical College and Hospital
2023
Central University of Punjab
2022
Manchester University
2020
Queen Elizabeth Hospital Birmingham
2020
Government Medical College, Amritsar
2009-2017
Guru Nanak Dev University
2017
Klebsiella pneumoniae causes infections in humans especially immunocompromised patients. About 80 % of nosocomial caused by K. are due to multidrug-resistant strains. The emergence antibiotic-resistant bacterial strains necessitates the exploration alternative antibacterial therapies, which led our group study ability viruses (known as bacteriophages or simply phages) treat mice challenged with pneumoniae. Phage SS specific for B5055 was isolated and characterized, its potential a...
Staphylococcus aureus remains the predominant pathogen in diabetic foot infections and prevalence of methicillin resistant S.aureus (MRSA) strains further complicates situation. The incidence MRSA infected ulcers is 15-30% there an alarming trend for its increase many countries. Diabetes acts as immunosuppressive state decreasing overall immune functioning body to worsen situation, wounds inflicted with drug represent a morbid combination patients. Foot caused by are associated increased...
Curcumin, very rightly referred to as "a wonder drug" is proven be efficacious in a variety of inflammatory disorders including cancers. Antiaging, anti-inflammatory, antioxidant, antitumor, chemosensitizing, P-gp efflux inhibiting, and antiproliferative activity are some the striking features curcumin, highlighting its importance chemotherapy. Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-My
Diabetic populations are more prone to developing wound infections which results in poor and delayed healing. Infection with drug resistant organisms further worsen the situation, driving searches for alternative treatment approaches such as phage therapy. Major drawback of therapy, however, is low persistence situ, suggesting refinement approach. In present work we address this issue by employing liposomes delivery vehicles. A liposome entrapped cocktail was evaluated its ability resolve a...
Staphylococcus comprises up to two-thirds of all pathogens in orthopaedic implant infections with two species respectively aureus and epidermidis, being the predominate etiological agents isolated. Further, emergence methicillin-resistant S. (MRSA), treatment has become more difficult, thus representing a devastating complication. Use local delivery system consisting S.aureus specific phage along linezolid (incorporated biopolymer) allowing gradual release at site represents new, still...
The emergence of drug resistance has rekindled interest in phage therapy as an alternative treatment option; its potency, safety, and proven efficacy are worth noting. However, still suffers from issues poor stability, narrow spectra, pharmacokinetic profiles. Therefore, it is essential to look into the use delivery systems for efficient lytic phages vivo present study evaluated nanostructured lipid-based carriers, i.e., transfersomes, transdermal encapsulating a methicillin-resistant...
Infections of bone and joint tissues following arthroplasty surgeries remain a major challenge in orthopaedic settings. Methicillin resistant Staphylococcus aureus (MRSA) is recognised as an established pathogen such infections. Combination therapy using linezolid bacteriophage impregnated biopolymer was investigated the present study alternative strategy to prevent MRSA colonisation on implant surface.Coating stainless steel grade K-wires achieved hydroxypropylmethlycellulose (HPMC) mixed...
The study aims to develop high drug-loaded (about 15% lipid matrix) curcumin solid nanoparticles (CSLNs) for wound healing. CSLNs prepared by hot, high-pressure homogenization, without using organic solvents, were optimized the Taguchi design followed central composite design. exhibited a assay/drug content (0.6% w/w), solubility (6 × 105 times), and EE (75%) with particle size < 200 nm (PDI—0.143). safe (in vitro in vivo), photostable, autoclavable, stable up one year at 30 °C under...
Phage therapy presents an alternative approach against the emerging methicillin-resistant Staphylococcus aureus (MRSA) threat. Some of problems encountered during isolation MRSA phages include high prevalence enteric in natural sources, nonspecific absorption viable phage, and formation pinpoint or tiny plaques. The phage isolated this study, MR-5, also formed plaques its host S. ATCC 43300 (MRSA), making detection enumeration difficult. An improved method increasing plaque size by...
Phage therapy presents an alternative therapeutic option in treating infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains not responding to antibiotic therapy. However, it is essential study the role of external factors that may influence yield and potency phage preparations intended for use various vitro vivo studies. The present focuses on effects calcium entire infection process a broad-spectrum lytic bacteriophage: MR-10. presence increased adsorption rate also...
Nasal carriers not only pose serious threat to themselves but also the community by playing an active role in dissemination of and life threatening S. aureus especially MRSA strains. The present study focuses on use broad spectrum lytic phage as decolonising agent. In addition, combined with mupirocin has been investigated effective regimen. effect adherence, invasion cytotoxic strains nasal epithelial cells was studied ex-vivo model cultured murine cells. This followed demonstration...
Free radicals and peroxides are involved in physiological phenomena such as synthesis of prostaglandin thromboxanes thought to participate aging process. also responsible for the pathogenesis various diseases like atherosclerosis, inflammatory malignancies etc. The objective present work was investigate possible role free process by studying age related changes lipid peroxidation certain antioxidant enzymes xanthine oxidase, superoxide dismutase, glutathione peroxidase glutathione. level...