A5082873486- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- CRISPR and Genetic Engineering
- Analytical chemistry methods development
- Bioinformatics and Genomic Networks
- Research Data Management Practices
- Telomeres, Telomerase, and Senescence
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Analytical Chemistry and Chromatography
- Pluripotent Stem Cells Research
- Electrohydrodynamics and Fluid Dynamics
- Ubiquitin and proteasome pathways
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Click Chemistry and Applications
- Odor and Emission Control Technologies
- RNA and protein synthesis mechanisms
- Water Treatment and Disinfection
- Environmental Monitoring and Data Management
Stevenage Bioscience Catalyst
2018-2025
John Wiley & Sons (United Kingdom)
2021
John Wiley & Sons (United States)
2021
MRC Human Genetics Unit
2020
Institute of Genetics and Cancer
2017
University of Edinburgh
2017
University of Oxford
2014-2015
Pediatrics and Genetics
2014-2015
Science Oxford
2014-2015
Genomics (United Kingdom)
2014-2015
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A HHV-6B, allows viral latency central nervous system other tissues, which can later be activated causing cognitive behavioral disturbances. Hence, this study was designed to evaluate possible association HHV-6B activation three different groups psychiatric patients. DNA qPCR, immunofluorescence FISH studies were carried out...
Here we present the first molecular imprinted polymer (MIP) that is able to attenuate biofilm formation of opportunistic human pathogen Pseudomonas aeruginosa through specific sequestration its signal molecule N-(3-oxododecanoyl)-l-homoserine lactone (3-oxo-C12-AHL). The MIP was rationally designed using computational modeling, and capacity specificity a corresponding blank toward P. (3-oxo-C12-AHL) analogue were tested. in presence polymers without studied scanning confocal laser...
In this study, the microbial community within compost, emitted into airstream, downwind and upwind from a composting facility was characterized compared through phospholipid fatty acid analysis 16S rRNA gene using denaturing gradient gel electrophoresis bar-coded pyrosequencing techniques. All methods used suggested that green-waste had significant impact upon bioaerosol composition. Daily variations of on-site airborne showed how specific site parameters such as compost process activity...
The identification of cancer-specific biomolecules is fundamental importance to the development diagnostic and/or prognostic markers, which may also serve as therapeutic targets.Some antigenic proteins are only normally present in male gametogenic tissues testis and not normal somatic cells.When these aberrantly produced cancer they referred cancer/testis (CT) antigens (CTAs).Some CTA genes have been proven encode immunogenic that used successful immunotherapy targets for various forms...
The identification of novel candidate markers is a key challenge in the development cancer therapies. This can be facilitated by putting accessible and automated approaches analysing current wealth 'omic'-scale data hands researchers who are directly addressing biological questions. Data integration techniques standardized, automated, high-throughput analyses needed to manage available as well help narrow down excessive number target gene possibilities presented modern databases system-level...
ELIXIR-UK is the UK node of ELIXIR, European infrastructure for life science data. Since its foundation in 2014, has played a leading role training both within and ELIXIR Training Platform, which coordinates delivers across all members. contributes to Platform's coordination supports development address key skill gaps amongst scientists. As part this work it acts as conduit nationally-important bioinformatics resources promote their activities community. also leads ELIXIR's flagship Portal,...
Bona fide germline genes have expression restricted to the germ cells of gonads. Testis-specific development-associated can become activated in cancer and potentially drive oncogenic process serve as therapeutic/biomarker targets; such are referred cancer/testis genes. Many silenced via hypermethylation CpG islands their associated transcriptional control regions upon treatment with DNA hypomethylating agents; hypomethylation-induced activation provides a potential combination approach...
G-quadruplex structures, formed from guanine rich sequences, have previously been shown to be involved in various physiological processes including cancer-related gene expression. Furthermore, G-quadruplexes found several oncogene promoter regions, and play a role the regulation of The mutagenic properties oxidative stress on DNA widely studied, as has association with carcinogenesis. Guanine is most susceptible nucleotide oxidation, such, G-rich sequences that form can viewed potential...
<ns3:p>One of the main goals ELIXIR-EXCELERATE project from European Union’s Horizon 2020 programme is to support a pan-European training increase bioinformatics capacity and competency across ELIXIR Nodes. To this end, Train-the-Trainer (TtT) has been developed by TtT subtask EXCELERATE’s Training Platform, try expose instructors aspects pedagogy evidence-based learning principles, help them better design, develop deliver high-quality in future. As first step towards such programme, an...
Metabolomics has come of age and is predicted to have a compound annual growth rate 30 % from 2014 2019 market value $2.1 billion by (Rohan 2014). While recent progress been driven technological advances in both analytical instrumentation software, the availability ring-fenced research funding some countries, insufficient attention focused on developing specialist training required support this growth. The international Society was established promote field (Goodacre 2005), stimulate...
Cell-surface contacts are vital for many eukaryotic cells. The surface provides anchorage (facilitating spreading and proliferation), is involved in sensation, i.e., via mechano-, osmo- chemoreceptors, addition nutrients may also be supplied vessels adjacent to the basal lamina. Hence, ability manipulate characteristics a mechanism directly influencing cell behaviour. Applications such as medical implants tissue engineering require biocompatible, stable surfaces controlling Mucin-coated...
ELIXIR is a pan-European intergovernmental organisation for life science that aims to coordinate bioinformatics resources in single infrastructure across Europe; training central its strategy, which develop community spans all member states. In an evidence-based approach strengthening programmes Europe, the Training Platform, led by EXCELERATE Quality and Impact Assessment Subtask collaboration with Coordinators Group, has implemented assessment strategy measure quality impact of entire...
Molecular modelling and computational approaches were used to design (virtual) molecularly imprinted binding sited for 170 amino acids, dipeptides tripeptides. Analysis of the energy ligands their corresponding virtual sites revealed a direct correlation between size ligand its affinity. Only tripeptides capable forming in polymers (MIPs) that are capable, theory, targets at micromolar concentrations. No appreciable specificity was demonstrated templates. It is possible conclude although...
The identification of cancer-restricted biomarkers is fundamental to the development novel cancer therapies and diagnostic tools. construction comprehensive profiles define tissue- cancer-specific gene expression has been central this. To this end, exploitation current wealth 'omic'-scale databases can be facilitated by automated approaches, allowing researchers directly address specific biological questions. Here we present CancerEST, a user-friendly intuitive web-based tool for candidate...