A5088156499- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Vibrio bacteria research studies
- Fungal Infections and Studies
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Enterobacteriaceae and Cronobacter Research
- Mycobacterium research and diagnosis
- Neonatal and Maternal Infections
- Antimicrobial Resistance in Staphylococcus
- Reproductive tract infections research
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Burkholderia infections and melioidosis
- Cervical Cancer and HPV Research
- Infectious Diseases and Mycology
- Pelvic floor disorders treatments
- Adolescent Sexual and Reproductive Health
- Nephrotoxicity and Medicinal Plants
- Pneumocystis jirovecii pneumonia detection and treatment
Christian Medical College & Hospital
2015-2024
Christian Medical College
2014-2024
Background: The emergence of antibiotic resistance among bacterial pathogens in the hospital and community has increased concern to health-care providers due limited treatment options. Surveillance antimicrobial (AMR) frequently isolated causing severe infections is great importance. data generated will be useful for clinicians decide empiric therapy on local epidemiological profile agents. This study aims monitor distribution pathogen their susceptibility pattern commonly used Materials...
India has a high burden of drug resistant TB, although there are few data on XDR-TB. Although XDR-TB existed previously in India, the definition not been widely applied, and surveillance using second line susceptibility testing performed. Our objective was to analyze clinical demographic risk factors associated with isolation MDR XDR TB as compared susceptible controls, at tertiary center.Retrospective chart review based positive cultures isolated volume mycobacteriology laboratory between...
The treatment of urinary tract infections (UTIs) has been complicated by the emergence multidrug-resistant, β-lactamase-expressing pathogens. As a result limited options, patients often require hospitalization and intravenous therapy. In essence, strong unmet need for oral antibiotics, active against extended-spectrum β-lactamase (ESBL) uropathogens emerged. Oral carbapenems (tebipenem sulopenem) cephalosporin/β-lactamase inhibitor combinations are in various stages clinical development...
Aim: The aim was to evaluate the in vitro activity of fosfomycin against common uropathogens a fosfomycin-naive population India. Methods: authors prospectively collected and tested all consecutive isolates Escherichia coli Enterococcus spp. from urine samples between December 2009 April 2010. Results: A total 3141 were included study, 2416 E. 725 Fosfomycin most active antibiotic both pathogens with an overall susceptibility 83 99% for spp, respectively. Among coli, 47.6% extended-spectrum...
The escalation in carbapenem resistance among Enterobacteriaceae has resulted a lack of effective therapeutic alternatives. Older antimicrobials, fosfomycin, nitrofurantoin and colistin for urinary tract infections (UTIs) caused by carbapenem-resistant (CRE) may be treatment options. objectives this study were to evaluate the utility treating UTI CRE molecular characterization plasmid-mediated mechanisms.Consecutive, non-duplicate isolates CR Escherichia coli Klebsiella spp. from urine...
Oral amoxicillin/clavulanate is a community workhorse antibiotic, routinely prescribed for respiratory tract infections, skin infections as well urinary (UTIs). Multiple adult and paediatric dose formulations of are available in different parts the world. In formulations, clavulanic acid restricted to 125 mg because tolerability issues. Despite its popular use 40 years, few pharmacokinetic/pharmacodynamic (PK/PD) studies were undertaken justify doses breakpoints currently various infections....
Rectovaginal group B Streptococcus (GBS) colonisation in pregnant individuals at the time of labour is a major risk factor for invasive GBS disease by age 7 days (early-onset disease). We aimed to investigate prevalence rectovaginal among women and vertical transmission their newborns across selected low-income middle-income African south Asian countries.
To estimate the prevalence of group B Streptococcus (GBS) carriage among pregnant women attending antenatal clinic, and colonization rates newborn born to colonized mothers.Women clinic between 35-37 weeks were screened using rectal lower vaginal swab. Swabs initially plated on sheep blood agar LIM broth. The broth was subcultured after 24 hours onto CHROMagar StrepB plates with all checked for growth at 48 hours. All babies mothers in study had surface swabs taken vertical transmission...
Objectives To determine the in vitro activity of antibiotics, including arbekacin, cefminox, fosfomycin and biapenem which are all still unavailable India, against Gram-negative clinical isolates. Methods We prospectively collected tested consecutive isolates Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa Acinetobacter spp. from blood, urine sputum samples between March November 2012. The minimum inhibition concentration (MIC) 16 antibiotics was determined by broth micro-dilution...
Objectives In rural pregnant Indian women, multiple missed antenatal screening opportunities due to inadequate public health facility-based result in undiagnosed HIV and sexually transmitted bloodborne infections (STBBIs) conditions (anaemia). Untreated complicate pregnancy management, precipitate adverse outcomes risk mother-to-child transmission. Additionally, a shortage of trained doctors, women’s preference for home delivery illiteracy affect service delivery. To address these issues, we...
Context: The modified Hodge test (MHT) is widely used as a screening for the detection of carbapenemases in Gram-negative bacteria. This has several pitfalls terms validity and interpretation. Also very low sensitivity detecting New Delhi metallo-β-lactamase (NDM). Considering degree dissemination NDM growing pandemic carbapenem resistance, more accurate alternative needed at earliest. Aims: study intends to compare performance MHT with commercially available Neo-Sensitabs -...
, an environmental organism, is emerging pathogen in patients chiefly with immune suppression. We report the draft genome of
Early antibiotic treatment for urinary tract infection (UTI) in young children can prevent renal scarring. Sensitivity of pyuria and positive urine nitrite test as indicators UTI are low, whereas results culture, the gold standard diagnosing UTI, may not be available 48--72 h. Novel markers rapid accurate diagnosis would help early initiation with suspected UTI. We studied utility neutrophil gelatinase-associated lipocalin (NGAL) an marker This study included 100 between 3 months 5 years...
Candida auris is an emerging, multidrug-resistant yeast transmitted in healthcare settings. Conventional methods of speciation are unable to identify C. species level. Three methods, namely VITEK® MS v.3.0, VITEK®2 and target sequencing the internal transcribed spacer (ITS) region 28S rRNA gene, were evaluated. Antifungal susceptibility testing (AFST) was also performed, risk factors for acquisition candidaemia studied. Between November 2016 2017, 203 spp. isolated from blood cultures, which...
Objectives Burkholderia pseudomallei, the causative agent for melioidosis, has become a public health problem in India and across world. Melioidosis can be difficult to diagnose because of inconsistent clinical presentations disease. This study aims determine genetic diversity among isolates B. pseudomaelli from order establish molecular epidemiology elucidate Southeast Asian association. Methods Molecular typing using multi locus sequence was performed on thirty one archived pseudomallei...
Cryptic aspergillosis, caused by cryptic species of Aspergillus, is increasingly reported in humans and causes significant morbidity mortality immunocompromised individuals. The main aim this study was to describe the occurrence entity at a large tertiary care centre analyse challenges identifying them routine diagnostic laboratory.This retrospective case review all patients diagnosed with Aspergillus from April 2019 February 2020. isolates were identified using conventional microbiological...
Background and Objectives: Discovered in 1983, Extended spectrum beta-lactamase (ESBL) producers are still the leading cause of infections India. Its prompt detection is crucial to clinical management. The Clinical Laboratory Standards Institute (CLSI) recommends phenotypic screening confirmatory tests identify ESBL producer making it cost time consuming for diagnostic laboratory. We compare here offering a solution CLSI recommendation. Methods: Nosocomial isolates E. coli (71) K. pneumoniae...
Serratia marcescens is an emerging nosocomial pathogen associated with urinary and respiratory tract infections. In this study, we determined the genome of a green pigment-producing clinical strain, U36365, isolated from hospital in Southern India. De novo assembly PacBio long-read sequencing indicates that U36365 consists chromosome 5.12 Mbps no plasmids.
Urinary tract infection (UTI) is common among children. Empiric antibiotics have to be started as early possible or it may lead an irreversible renal parenchymal damage and scarring in The objectives were determine the prevalence microbial profile of paediatric UTI antimicrobial susceptibility pattern.This a retrospective study which looked at urine cultures children below 15 years that sent during period.Among total only 21.2% showed significant growth organisms. most organism isolated was...
Candida utilis is an emerging fungal pathogen in blood. The main aim of this study was to describe the prevalence, methods speciation and antifungal susceptibility at a tertiary care centre.This retrospective carried out centre South India. Over period 1 year, three were isolated from blood culture identified by MALDI-TOF MS Version 3.2 confirmed ITS sequencing. Susceptibility testing micro broth dilution.All patients had common risk factor prolonged ICU stay but source infection could not...
Invasive group B Streptococcal disease (iGBS) is an important cause of morbidity and mortality in neonates for which the development efficacious vaccine remains a global health imperative. The knowledge about serotype distribution iGBS component formulation Capsular polysaccharide (CPS)-based vaccine. However, there were absolute lack information on invasive GBS isolates from Indian subcontinent. Methods This study has assessed antimicrobial susceptibility profile streptococcal period 13...