A5089164822- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Erythrocyte Function and Pathophysiology
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Neuroendocrine regulation and behavior
- Connective tissue disorders research
- Environmental DNA in Biodiversity Studies
- Genomics and Rare Diseases
- Heat shock proteins research
- Cancer Research and Treatments
- Epilepsy research and treatment
- Microtubule and mitosis dynamics
- Genetic Neurodegenerative Diseases
- Anaerobic Digestion and Biogas Production
- Neurological diseases and metabolism
- Genetic factors in colorectal cancer
- Hereditary Neurological Disorders
- Skin and Cellular Biology Research
- Child Development and Digital Technology
- Connexins and lens biology
- Glycosylation and Glycoproteins Research
Scientific and Technological Research Council of Turkey
2014-2019
TUBITAK BILGEM
2015-2019
Istanbul University
2014-2016
Istanbul University-Cerrahpaşa
2014-2016
Autism spectrum disorder (ASD) is one of the lifelong existing disorders. Abnormal methylation status gene promoters oxytonergic system has been implicated as among etiologic factors ASDs. We, therefore, investigated frequency oxytocin receptor (OXTR) promoter from peripheral blood samples children with autistic features. Our sample includes 66 in total (22-94 months); 27 ASDs according to DSM-IV-TR and Childhood Rating Scale (CARS) 39 who do not have any like symptoms healthy control group....
Background Laryngeal squamous cell carcinoma (SCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types head and neck SCC worldwide. Incidences laryngeal have been reported to increase recently. In this study, we aimed explore biological effects miR-145 on cancer cells. Methods The relative level in tumor tissues normal samples was investigated. Then, Hep-2 cells were utilized for functional analysis miR-145. proliferation abilities transfected measured...
The cancer stem-like cells (CSLCs) are tumorigenic promoting initiation, progression, and spread of the tumor. Accumulating evidences suggested presence CSLCs in distinct tumors including laryngeal squamous cell carcinoma (LSCC). MicroRNAs have been proposed as significant regulators carcinogenesis, several them demonstrated to direct roles survival CSLCs. In this study, we aimed explore role miR-145, which is downregulated LSCC, on stem potency cells. We initially showed downregulation...
Larynx cancer (LCa) is an aggressive malignancy, which the second most common malignant neoplasm of head and neck squamous cell carcinoma. Its incidences have been reported to increase therapeutic options mostly fail give positive clinical response especially for advanced LCa cases. In this study we aimed isolate stem-like cells from freshly resected tumor specimens characterize them by quantitative real time PCR (qRT-PCR) expression stem markers including SOX2, OCT4, KLF4, ABCG2, CXCR4...
Emerging evidences proposed that microRNAs are associated with regulation of distinct physio-pathological processes including development normal stem cells and carcinogenesis. In this study we aimed to investigate microRNA profile cancer stem-like (CSLCs) isolated form freshly resected larynx (LCa) tissue samples. CD133 positive (CD133+) were from LCa tumor specimens. MicroRNA 12 pair CD133+ CD133− was determined using microarray differential expressions selvected validated by quantitative...
Background Laryngeal squamous cell carcinoma (SCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types head and neck SCC worldwide. The recent studies suggested that αB-crystallin might play important role in tumorigenesis. purpose this study was to investigate expression level metastatic nonmetastatic laryngeal tissues determine its prognostic significance. Methods Alpha-B-crystallin status metastatic, SCC, normal tissue samples investigated by...
Purpose : Martsolf (MS) and Warburg micro syndromes (WARBM) are rare autosomal recessive inherited allelic disorders, which share similar clinical features including microcephaly, intellectual disability, brain malformations, ocular abnormalities, spasticity. Here, we revealed the functions of novel mutations in RAB3GAP1 a Turkish female patient with MS two siblings WARBM. We also present review patients as well all reported pathogenic literature. Methods phenotype WARBM having more severe...
The draft genome sequences of two heat-resistant mutant strains, A52 and B41, derived from Rhodobacter capsulatus DSM 1710, with different hydrogen production levels, are reported here. These may help understand the molecular basis heat resistance in R. capsulatus.