A5102008153- Genomics and Phylogenetic Studies
- Genomics and Rare Diseases
- Legume Nitrogen Fixing Symbiosis
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- Microbial Community Ecology and Physiology
- Genomic variations and chromosomal abnormalities
- Biofuel production and bioconversion
- Chromosomal and Genetic Variations
- Microbial bioremediation and biosurfactants
- Liver Disease Diagnosis and Treatment
- Heavy metals in environment
- Nematode management and characterization studies
- Liver physiology and pathology
- Coccidia and coccidiosis research
- Vascular Tumors and Angiosarcomas
- Plant Gene Expression Analysis
- Plant Micronutrient Interactions and Effects
- Connective tissue disorders research
- Environmental DNA in Biodiversity Studies
- Craniofacial Disorders and Treatments
- Helminth infection and control
- Endoplasmic Reticulum Stress and Disease
- Polysaccharides and Plant Cell Walls
- Testicular diseases and treatments
Scientific and Technological Research Council of Turkey
2008-2018
Dokuz Eylül University
2018
Biotechnology Institute
2009-2018
TÜBİTAK Marmara Research Center
2013-2017
University of Georgia
2011
Chronic hepatic injury and inflammation from various causes can lead to fibrosis cirrhosis, potentially predisposing hepatocellular carcinoma. The molecular mechanisms underlying its progression remain incompletely understood. Using a proteo-transcriptomics approach, we analyze liver plasma samples 330 individuals, including 40 healthy individuals 290 patients with histologically characterized due chronic viral infection, alcohol consumption, or metabolic dysfunction-associated steatotic...
<h3>Background</h3> Human de novo single-nucleotide variation (SNV) rate is estimated to range between 0.82–1.70×10<sup>−8</sup> mutations per base generation. However, contribution of early postzygotic the overall human SNV unknown. <h3>Methods</h3> We performed deep whole-genome sequencing (more than 30-fold coverage individual) whole-blood-derived DNA samples a healthy monozygotic twin pair and their parents. examined genotypes each individual simultaneously for SNVs discovered regarding...
We present a novel multisystem disease in two siblings with clinical features resembling lysosomal storage disease. These included coarse face, dysostosis multiplex, respiratory difficulty, proteinuria glomerular foamy cells, neurological involvement developmental delays, pyramidal signs, and severe chronic anemia. Detailed enzymatic analysis for diseases whole-exome sequencing studies excluded known the proband. Subsequently, genome-wide genotyping exome of family indicated large homozygous...
In this study, the phytoremediation capacity of Azolla filiculoides Lam. for water resources contaminated with petroleum hydrocarbons was investigated. The plants were grown in nitrogen-free Hoagland nutrient solution containing 0.005%, 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% crude oil under greenhouse conditions 15 days. Although growth rate not negatively influenced by presence media concentration 0.005% 0.01% v/v, a gradual impeding effect has been observed at concentrations...
Fasciola hepatica causes chronic liver disease, fasciolosis, leading to significant losses in the livestock economy and concerns for human health many countries. The identification of F. genes involved parasite's virulence through modulation host immune system is utmost important comprehend evasion mechanisms parasite develop more effective strategies against fasciolosis. In this study, identify putative which are associated with immunomodulation, we explored whole transcriptome an adult...
Small GTP-binding genes play an essential regulatory role in a multitude of cellular processes such as vesicle-mediated intracellular trafficking, signal transduction, cytoskeletal organization, and cell division plants animals. Medicago truncatula Lotus japonicus are important model for studying legume-specific biological nodulation. The publicly available online resources these from websites http://www.ncbi.nih.gov, http://www.medicago.org, http://www.tigr.org, related sites were searched...
Abstract Background Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, Arabidopsis thaliana , provides means explore genomic complexity. Results A genome-wide physical map a rapid-cycling strain B. oleracea was constructed integrating high-information-content fingerprinting (HICF) Bacterial Artificial Chromosome (BAC) clones with hybridization sequence-tagged probes. Using 2907 contigs two or more BACs, we performed several...
Introduction Rare and ultra-rare genetic conditions significantly contribute to infant morbidity mortality, often presenting with atypical features heterogeneity that complicate management. Rapid genome sequencing (RGS) offers a timely cost-effective approach diagnosis, aiding in early clinical management reducing unnecessary interventions. This pilot study represents the inaugural use of next-generation (NGS) as diagnostic instrument for critically ill neonatal pediatric ICU patients...
Polymicrogyria is a disorder of neuronal migration characterized by excessive cortical folding and partially fused gyri separated shallow sulci. Homozygous mutations in the GPR56 gene, which regulates neural precursor cells, are associated with bilateral frontoparietal polymicrogyria (BFPP) syndrome including white matter changes, brainstem cerebellar involvement. Herein, we describe three siblings consanguineous parents homozygous germline mutation (p.R271*) located seventh exon gene that...
Abstract ARF1 (ADP‐ribosylation factor 1) and SAR1 (secretion‐associated RAS super family) are involved in the formation budding of vesicles throughout plant endomembrane systems. The molecular mechanisms this transport have been studied extensively mammalian yeast cells. However, very little is known about coat protein complex (COP) recruitment COP‐vesicle cargoes plants. To provide insights into vesicular trafficking Pisum sativum L., we investigated mRNA expression patterns roots shoots...
The improvements in high throughput sequencing technologies (HTS) made clinical projects such as ClinSeq and Genomics England feasible. Although there are significant accuracy reproducibility of HTS based analyses, the usability these types data for diagnostic prognostic applications necessitates a near perfect generation. To assess widely used platform accurate reproducible terms robustness, we generated whole genome shotgun (WGS) sequence from genomes two human individuals different...
Various causes of chronic hepatic injury and inflammation can lead to fibrosis cirrhosis, potentially predisposing individuals hepatocellular carcinoma. Despite extensive research, the molecular mechanisms underlying liver its associated progression cancer remain incompletely understood. In this study, we employed an integrated proteo-transcriptomics approach characterize pathophysiology in both plasma samples from 330 individuals. This cohort included 40 healthy subjects 290 patients with...
The draft genome sequences of two heat-resistant mutant strains, A52 and B41, derived from Rhodobacter capsulatus DSM 1710, with different hydrogen production levels, are reported here. These may help understand the molecular basis heat resistance in R. capsulatus.