A5052946428- Evolutionary Psychology and Human Behavior
- Primate Behavior and Ecology
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Hormonal and reproductive studies
- Birth, Development, and Health
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Evolutionary Game Theory and Cooperation
- Diet and metabolism studies
- Health disparities and outcomes
- Zoonotic diseases and public health
- Atherosclerosis and Cardiovascular Diseases
- Climate Change and Health Impacts
- Indigenous Health and Education
- Genetic Associations and Epidemiology
- Psychological Well-being and Life Satisfaction
- Human-Animal Interaction Studies
- Demographic Trends and Gender Preferences
- Animal Behavior and Reproduction
- Adipokines, Inflammation, and Metabolic Diseases
- Parasite Biology and Host Interactions
- Nutritional Studies and Diet
- interferon and immune responses
- Cognitive Abilities and Testing
Arizona State University
2016-2025
Google (United States)
2023
Saint Luke's Health System
2018-2020
Center for Global Health
2019
Chapman University
2018
University of California, Santa Barbara
2013-2016
Santa Fe Institute
2014
University of New Mexico
2014
University of Richmond
2014
University of Washington
2009-2012
Epigenetic biomarkers of aging (the "epigenetic clock") have the potential to address puzzling findings surrounding mortality rates and incidence cardio-metabolic disease such as: (1) women consistently exhibiting lower than men despite having higher levels morbidity; (2) racial/ethnic groups different even after adjusting for socioeconomic differences; (3) black/white cross-over effect in late adulthood; (4) Hispanics United States a longer life expectancy Caucasians burden traditional risk...
Parasitic worms influence human fecundity infect 2 billion people globally. Mostly, such infections are symptomless and individual worm burdens low. Blackwell et al. monitored the of Tsimane women in Bolivia. These have on average 10 children their lifetimes. However, if they had successive hookworm infections, lifetime births dropped to 7. Surprisingly, were chronically infested with roundworm, as many 12 children. effects may relate balance immune responses that different induce, rather...
Amazonian populations are exposed to diverse parasites and pathogens, including protozoal, bacterial, fungal helminthic infections. Yet much knowledge of the immune system is based on industrialised where these infections relatively rare.This study examines distributions age-related differences in 22 measures function for Bolivian forager-horticulturalists US European populations.Subjects were 6338 Tsimane aged 0-90 years. Blood samples collected between 2004-2014 analysed 5-part blood...
The apolipoprotein E4 (E4) allele is present worldwide, despite its associations with higher risk of cardiovascular morbidity, accelerated cognitive decline during aging, and Alzheimer's disease (AD). especially prevalent in some tropical regions a high parasite burden. Equatorial populations also face potential dual burden prevalence combined parasitic infections that can reduce performance. We examined the interactions E4, burden, performance traditional, nonindustrialized population...
Hunters exhibit high skill across the life span, individuals vary substantially in skill, and age-related peaks sites.
The challenge hypothesis posits that acute increases in testosterone (T) during male-male competition enhance performance and survivability while limiting the physiological costs of consistently high T. Human research focuses on young men industrial populations, who have higher baseline T levels than subsistence populations. We tested whether Tsimane, pathogenically stressed forager-horticulturalists Bolivian Amazon, would express response to physical competition. Saliva was collected from...
Cognitive performance is characterized by at least two distinct life course trajectories. Many cognitive abilities (e.g., "effortful processing" abilities, including fluid reasoning and processing speed) improve throughout early adolescence start declining in adulthood, whereas other "crystallized" like vocabulary breadth) adult life, remaining robust even late ages. Although schooling may impact "reserve," it has been argued that these age patterns of are human universals. Here we examine...
Abstract Objectives Resting metabolic rate (RMR) reflects energetic costs of homeostasis and accounts for 60 to 75% total energy expenditure (TEE). Lean mass physical activity account much RMR variability, but the impact prolonged immune activation from infection on human is unclear in naturalistic settings. We evaluate effects mass‐corrected among Bolivian forager‐horticulturalists, assess whether declines more slowly with age than hygienic sedentary populations, as might be expected if...
In post-industrial settings, apolipoprotein E4 ( APOE4 ) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments higher pathogenic diversity low We hypothesize that high-pathogen energy-limited contexts, allele confers benefits by reducing innate inflammation when uninfected, while maintaining lipid levels buffer costs immune activation during infection. Among Tsimane forager-farmers Bolivia N =...
In high-income countries, one's relative socio-economic position and economic inequality may affect health well-being, arguably via psychosocial stress. We tested this in a small-scale subsistence society, the Tsimane, by associating household wealth (n = 871) community-level 40, Gini 0.15-0.53) with range of psychological variables, stressors, outcomes (depressive symptoms [n 670], social conflicts 401], non-social problems 398], support 399], cortisol 811], body mass index 9,926], blood...
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes among a long list of "lifestyle" that were rare throughout human history but now common. The evolutionary mismatch hypothesis posits humans evolved in environments radically differ from those we currently experience; consequently, traits once advantageous may be "mismatched" disease causing. At genetic level, this predicts loci with selection will exhibit "genotype by environment"...
In Brief Objective: Detailed characterization of progesterone and ovulation across the menopausal transition provides insight into conception risk mechanisms reproductive aging. Methods: Participants (n = 108, aged 25-58 y) collected daily urine specimens for 6-month intervals in each 5 consecutive years. Specimens were assayed pregnanediol glucuronide (PDG), luteinizing hormone (LH), follicle-stimulating (FSH), estrone (E1G). Reproductive stage was determined using cycle length variance. A...
Controversy over the adaptive significance of male hunting in subsistence societies hinges on relative importance familial provisioning and mate-quality signalling. This paper examines proximate ultimate motivations behaviour from a neuroendocrine perspective, using salivary testosterone cortisol data collected before, during after focal follows 31 Tsimane hunters aged 18–82 years. Despite circadian declines hormone levels, increased at time kill, remained high as successful returned home....
Abstract Objectives Despite well‐known fitness advantages to males who produce and maintain high endogenous testosterone levels, such phenotypes may be costly if testosterone‐mediated investment in reproductive effort trade‐off against somatic maintenance. Previous studies of androgen‐mediated trade‐offs human immune function find mixed results, part because most either focus on a few indicators immunity, are confounded by phenotypic correlation, or observational. Here the association...
Abstract Women exhibit greater morbidity than men despite higher life expectancy. An evolutionary history framework predicts that energy invested in reproduction trades-off against investments maintenance and survival. Direct costs of may therefore contribute to morbidity, especially for women given their direct energetic contributions reproduction. We explore multiple indicators somatic condition among Tsimane forager-horticulturalist (Total Fertility Rate = 9.1; n 592 aged 15–44 years, 277...
Abstract Introduction We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane Moseten, who lead a subsistence lifestyle. Methods Participants from population‐based samples ≥ 60 years age ( n = 623) were assessed using adapted versions Modified Mini‐Mental State Examination, informant interview, longitudinal testing brain computed tomography (CT) scans. Results exhibited five cases (among 435; crude 1.2%, 95% confidence interval [CI]: 0.4, 2.7);...
ABSTRACT Evolutionary theories of aging posit that greater reproductive effort causes somatic decline given a fundamental trade‐off between investing energy in reproduction and repair. Few studies high fertility human populations support this hypothesis, problems phenotypic correlation can obscure the expected condition. This cross‐sectional study investigates whether is associated with reduced calcaneal bone mineral density (BMD) among female Tsimane forager‐farmers lowland Bolivia. We also...