A5042369584- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Glioma Diagnosis and Treatment
- HIV-related health complications and treatments
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Mitochondrial Function and Pathology
- Cancer Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Medical Imaging and Pathology Studies
- Vasculitis and related conditions
- Poverty, Education, and Child Welfare
- Cerebrospinal fluid and hydrocephalus
- Historical Studies in Science
- History of Medical Practice
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Infectious Encephalopathies and Encephalitis
- Management of metastatic bone disease
- COVID-19 Clinical Research Studies
- Adolescent Sexual and Reproductive Health
- Head and Neck Surgical Oncology
Stellenbosch University
2018-2022
Tygerberg Children’s Hospital
2021
Tygerberg Hospital
2019
BackgroundChildren with HIV-associated tuberculosis (TB) have few antiretroviral therapy (ART) options. We aimed to evaluate the safety and pharmacokinetics of dolutegravir twice-daily dosing in children receiving rifampicin for TB.MethodsWe nested a two-period, fixed-order pharmacokinetic substudy within open-label, multicentre, randomised, controlled, non-inferiority ODYSSEY trial at research centres South Africa, Uganda, Zimbabwe. Children (aged 4 weeks <18 years) TB who were eligible...
Logistic regression (LR) is the most common prediction model in medicine. In recent years, supervised machine learning (ML) methods have gained popularity. However, there are many concerns about ML utility for small sample sizes. this study, we aim to compare performance of 7 algorithms 1-year mortality and clinical progression AIDS a cohort infants living with HIV from South Africa Mozambique. The data set (n = 100) was randomly split into 70% training 30% validation set. Seven (LR, Random...
Reports of posttreatment control following antiretroviral therapy (ART) have prompted the question how common immune HIV infection is in absence ART. In contrast to adult infection, where elite controllers been very well characterized and constitute approximately 0.5% infections, few data exist address this paediatric infection.We describe 11 ART-naive from 10 cohorts HIV-infected children being followed South Africa, Brazil, Thailand, Europe.All but one (91%) are females. The median age at...
Objectives: Early infant HIV diagnosis and antiretroviral therapy (ART) initiation are now implemented shortly after birth. Maintaining monitoring ART adherence is difficult requires frequent visits. We, therefore, investigated whether antibodies HIV-1 DNA levels markers of cumulative viremia. Design: We conducted a cross sectional investigation at 2 years age in well characterized cohort 31 children who started Methods: were measured by combination the Abbott ARCHITECT Ag/Ab Combo Geenius...
To evaluate the proportion of children with lopinavir Cmin ≥1 mg/L when receiving a novel 8-hourly lopinavir/ritonavir dosing strategy during rifampicin co-treatment.
Paediatric HIV spontaneous controllers (HSCs) are a unique and understudied population with potential to inform alternative treatment options for patients living HIV. As HSCs so rare often not recognised prior antiretroviral (ART) initiation, it can be difficult clinicians optimally manage this group. We describe the diagnosis, history management of three paediatric HSCs, two girls boy who were followed 2, 1.25 10.4 years, respectively, before starting ART. All had low but detectable viral...