A5042009156- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Systemic Lupus Erythematosus Research
- Photosynthetic Processes and Mechanisms
- Protease and Inhibitor Mechanisms
- Chemical synthesis and alkaloids
- Spectroscopy and Quantum Chemical Studies
- Alkaloids: synthesis and pharmacology
- Otitis Media and Relapsing Polychondritis
- Vasculitis and related conditions
- Asymmetric Synthesis and Catalysis
- Cell Adhesion Molecules Research
- Natural product bioactivities and synthesis
- Photoreceptor and optogenetics research
- Bone Metabolism and Diseases
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Synthetic Organic Chemistry Methods
- Inflammasome and immune disorders
- Cardiovascular Effects of Exercise
- Ocular Surface and Contact Lens
- Peptidase Inhibition and Analysis
Okayama University
2017-2024
Yokohama City University
2007-2022
Yokohama Rosai Hospital
2022
National Center For Child Health and Development
2013-2014
Tokyo University of Technology
2013
Kanagawa Children's Medical Center
2012
Daiichi-Sankyo (Japan)
2005-2010
Tokai University
2007
Ehime University
2007
Tohoku University
1992-1997
Photosynthetic water oxidation is catalyzed by the Mn4CaO5 cluster of photosystem II (PSII) with linear progression through five S-state intermediates (S0 to S4). To reveal mechanism oxidation, we analyzed structures PSII in S1, S2, and S3 states x-ray free-electron laser serial crystallography. No insertion was found but flipping D1 Glu189 upon transition leads opening a channel provides space for incorporation an additional oxygen ligand, resulting open cubane Mn4CaO6 oxyl/oxo bridge....
This report aimed to scrutinize the prevalence of Behçet's disease (BD)-related clinical manifestations based on age- and sex-specific subgroups using a Japanese nationwide registration database.The database newly registered BD was obtained from Ministry Health, Labour Welfare. Patients who met International Criteria for Disease were selected analysed.Among 6627 cases, 2651 (40.0%) men 3976 (60.0%) women with median age 39 years (interquartile range: 31-50 years). Ocular lesion more common...
Photosystem II (PSII) catalyzes light-induced water oxidation through an S i -state cycle, leading to the generation of di-oxygen, protons and electrons. Pump–probe time-resolved serial femtosecond crystallography (TR-SFX) has been used capture structural dynamics light-sensitive proteins. In this approach, it is crucial avoid light contamination in samples when analyzing a particular reaction intermediate. Here, method for determining condition that avoids PSII microcrystals while...
Background: This study aimed to establish an automatic and accurate method for identifying patient activity using wearable devices facilitate simple measurement of the severity disease, such as chronic obstructive pulmonary disease (COPD), diagnosis arrhythmias Holter electrocardiogram (ECG). Methods: Nine-axis accelerometers were attached five different parts body 30 healthy participants, nine activities performed in sequence. Results: Overall, dominant wrist, non-dominant chest yielded...
Abstract Coloboma and various ocular abnormalities have been described in CHARGE syndrome, although the severity of visual impairment varies from case to case. We conducted a multicenter study clarify ophthalmic features patients with molecularly confirmed syndrome. Thirty‐eight eyes 19 syndrome CHD7 mutations treated at four centers were retrospectively studied. Colobomata affected posterior segment 35 18 patients. Both retinochoroidal optic disk colobomata bilaterally observed 15...
Abstract The strongest genetic risk factor of Behçet’s disease (BD) is HLA-B*51 . Our group previously reported that HLA-A*26 independently associated with the onset BD apart from Here, we re-evaluated association between and in Japanese population. We also performed a comprehensive literature search meta-analyzed extracted published data concerning relationship to estimate odds ratio (OR) BD. In this study, genotyped 611 patients 2,955 unrelated ethnically matched healthy controls....
During the past decade, considerable efforts and resources have been devoted to elucidating multiple genetic environmental determinants responsible for hypertension its associated cardiovascular diseases. The success of positional cloning, fine mapping, linkage analysis based on whole-genome screening, however, has limited in identifying affecting diseases, suggesting that new research strategies genome-wide typing may be helpful. Disease association (case-control) studies using...
Refractive changes are reportedly affected by age, sex, and current refractive error. To clarify the pattern of in a Japanese population, we conducted 5-year follow-up longitudinal analysis spherical equivalent (SE) with stratification SE 593,273 eyes from individuals ages 3-91 years. The change myopic shift dramatically increased over time after age 4 years, largest was observed both males females who were 8 years at baseline [males: - 2.654 ± 0.048 diopters (D); females: 3.110 0.038 D]....
Objectives: This study aimed to identify patients with high-probability of ocular involvement Behçet's disease (BD). Methods: The Japanese Ministry Health, Labour and Welfare provided dataset ongoing nationwide BD registration project. A patient who had confirmed was suspected have registered. We mainly analyzed newly registered the data for all demographic diagnostic parameters regardless fulfilment any criteria. Results: Among 3213 or possible BD, 1382 (43.0%) were men 1831 (57.0%) women a...
Background: Clinical data of patients with entro-, vasculo-, and neuro-variant possible Behçet's disease (BD) based on Japanese criteria has not yet comprehensively reported. Methods: This ongoing nation-wide registration been carried out by the Ministry Health, Labour Welfare. The asked physicians who diagnosed a patient confirmed or BD to register filling form. provided us dataset after unlinkable anonymization. We analyzed 2003-2014 database generated from early stage new cases. Results:...
<strong>Background:</strong> The 6 min walk test is widely used to measure the severity of COPD, but this imposes an extensive burden on patients and medical staff. As alternative test, measurement activity amount during daily activities that cause COPD feel shortness breath can be acquired using wearable devices, measurements between healthy people compared. Accordingly, based machine learning, we first evaluated accuracy accelerometers in recognizing such activities....
Optically pure ethyl 5-hydroxycyclopent-1-enecarboxylate has been obtained with its acetate in both enantiomeric forms excellent optical yields from racemic by lipase-mediated kinetic resolution. The optically (R)-enantiomer thus transformed into two naturally occurring iridoid monoterpenes, (+)-mitsugashiwalactone and (-)-dolichodial.
Vogt-Koyanagi-Harada (VKH) disease is a systemic inflammatory disorder that affects pigment cell-containing organs such as the eye (e.g., chronic and/or recurrent granulomatous panuveitis). While exact etiology and pathogenic mechanism of VKH are unclear, HLA-DR4 alleles have been documented to be strongly associated with in various ethnic groups. Recently, genome-wide association study (GWAS) found two new genetic risk factors (IL23R-C1orf141 ADO-ZNF365-EGR2) non-HLA region from Han Chinese...
Many studies have investigated the relationship of paired box 6 (PAX6) gene polymorphisms with risk high myopia, but results across remain inconsistent and ambiguous. In present work, we whether PAX6 are associated myopia in a Japanese population.A total 1,585 patients (spherical equivalent [SE] <-9.00 diopters [D]) 1,011 healthy controls (SE≥-1.00 D) were recruited. To compare genotype frequencies between cases controls, genotyped five single nucleotide that reportedly high/extreme myopia:...
All of three 2-azaspiro[5.5]undecan-8-ol alkaloids isolated from the Nitraria plants, (+)-nitramine, (+)-isonitramine, and (-)-sibirine, have been synthesized stereoselectively in natural forms starting racemic 2-carbethoxy-2-cyclohexen-1-ol employing lipase-mediated kinetic resolution radical cyclization as key steps.