A5101944251- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Radiomics and Machine Learning in Medical Imaging
- Heme Oxygenase-1 and Carbon Monoxide
- Porphyrin Metabolism and Disorders
- Genetics and Neurodevelopmental Disorders
- Neonatal Health and Biochemistry
- Dementia and Cognitive Impairment Research
- Medical Imaging and Analysis
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Advanced Neuroimaging Techniques and Applications
- Neurological and metabolic disorders
- Autoimmune Neurological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Machine Learning in Healthcare
- Nanocluster Synthesis and Applications
- Mitochondrial Function and Pathology
Qilu Hospital of Shandong University
2016-2024
Shandong University
2019
Xiangya Hospital Central South University
2013-2016
Central South University
2012-2016
Hippocampal morphological change is one of the main hallmarks Alzheimer's disease (AD). However, whether hippocampal radiomic features are robust as predictors progression from mild cognitive impairment (MCI) to AD dementia and these provide any neurobiological foundation remains unclear. The primary aim this study was verify can serve magnetic resonance imaging (MRI) markers for AD. Multivariate classifier-based support vector machine (SVM) analysis provided individual-level predictions...
Abstract Precision medicine for Alzheimer's disease (AD) necessitates the development of personalized, reproducible, and neuroscientifically interpretable biomarkers, yet despite remarkable advances, few such biomarkers are available. Also, a comprehensive evaluation neurobiological basis generalizability end‐to‐end machine learning system should be given highest priority. For this reason, deep model (3D attention network, 3DAN) that can simultaneously capture candidate imaging with an...
Osteoporosis is a serious social issue nowadays. Both the high morbidity and its common complication osteoporotic fracture load heavy burden on whole society. The adipose tissue biggest endocrinology organ that has different function bone. adipocytes are differentiated from same cell lineage with osteoblast, they can secrete multiple adipokines various functions bone remolding. Recently, several novel have been identified investigated thoroughly. In this paper, we would like to highlight...
Abstract Vaspin (visceral adipose tissue-derived serine protease inhibitor) is a newly discovered adipokine that widely participates in diabetes mellitus, polycystic ovarian syndrome and other disorders of metabolism. However, the effect vaspin on regulation osteogenesis mechanism responsible are still unclear. Here, we found can attenuate osteogenic differentiation preosteoblast cell line MC3T3-E1 dose-dependent way; also, during this process, expression miRNA-34c (miR-34c) was...
Background: Abnormal immune responses are involved in the development of Parkinson's disease (PD), and also affect peripheral blood lymphocytes. The profile lymphocyte subsets whether it is relevant to clinical features PD patients remains controversial. Methods: To explore role lymphocytes (NK cells, B CD3+ T CD3+CD4+ cells CD3+CD8+ cells) PD, a case-control study including 127 148 healthy controls was conducted, subpopulations participants were analysed by FACSCalibur flow cytometer....
Objective Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide. Mitochondrial dysfunction suspected as one of pathogenic mechanisms PD. Growth/differentiation Factor-15 (GDF15) has been reported to affect mitochondrial function in However, relationship between and GDF15 induction not explained well. Hence, we aimed reveal effect on SH-SY5Y cells with rotenone toxicity, a cell model Methods were exposed 1 μM PD model. Cells transfected GDF15-overexpression...
The aim of this study was to investigate the effect minocycline in rats with rotenone-induced Parkinson’s disease (PD). open field test performed determine motor ability rats. Double immunofluorescence staining used detect expression tyrosine hydroxylase (TH) and Nurr1 substantia nigra (SN) relative protein levels TH, Nurr1, total- phosphorylated-cAMP-response element binding (CREB) were determined by western blot analysis. production reactive oxygen species (ROS) nitric oxide (NO) detected...
Diffusion tensor imaging (DTI) has been widely used to identify structural integrity and delineate white matter (WM) degeneration in Alzheimer's disease (AD). However, the validity replicability of ability discriminate AD patients normal controls (NCs) WM measures are limited due use small cohorts diverse image processing methods. As yet, we still do not have a clear idea whether characteristics biomarkers for AD. We conducted competition with diffusion measurements along 18 fiber tracts as...
Non-motor symptoms are common in Parkinson's disease (PD) and can even be used as part of the supportive criteria for diagnosis. Chronic inflammation is involved every stage PD. Disorders immune system affect peripheral blood. Whether humoral response associated with non-motor PD remains unknown.Mann-Whitney tests Bonferroni correction were to compare serum levels IgG, IgA, IgM, C3, C4 between 180 sporadic patients 187 healthy controls. Multiple regression models conducted assess...
Rationale: Parkinsonism can be secondary to many internal diseases, in some certain conditions, it seems that the clinical manifestations of parkinsonism presenting reversible. We report a case patient with pseudohypoparathyroidism, who improved markedly after supplement serum calcium. Patient concerns and diagnoses: A 52-year-old woman acute was diagnosed as pseudohypoparathyroidism conducting brain computed tomography, laboratory examinations, gene detection. The son also examined had ever...
Abstract Background Eukaryotic translation initiation factor 4-gamma 1 ( EIF4G1 ) gene mutations have recently been reported in autosomal dominant, late-onset Parkinson’s disease (LOPD). We carried out genetic analysis to determine the prevalence of variants an ethnic Chinese population and better understand association between PD. Methods conducted a comprehensive cohort 29 probands LOPD families. Polymerase chain reaction (PCR) sequencing was entire exonic regions exon-intron boundaries....
Parkinson's disease (PD) is the second most common neurodegenerative in world, and type 2 diabetes (T2DM) PD are influenced by genetic environmental factors. Mitochondrial dysfunction inflammation pathogenic mechanisms of both diseases. However, close association between T2DM specific relationship them not yet clear. This study aimed to reveal connection two diseases establishing a mouse model comorbid T2DM, as well Bv2 cell model.
Abstract Background: Hippocampal morphological change is one of the main hallmarks Alzheimer's disease (AD). The primary aim this study to explore whether radiomics feature a robust biomarker for AD and further biological basis those features.Methods: radiomic features were extracted classification prediction using support vector machine (SVM) with 1943 subjects (multi-site).Results: Multivariate classifier-based SVM analysis provided individual-level predictions distinguishing patients...
A new dahlia-like TiO 2 possessing both an anatase/TiO (B) phase junction and high specific surface area is fabricated by a facile green DES-tuning strategy able to greatly boost the photocatalytic degradation of persistent tetracycline.
ABSTRACT Aims To investigate the effect of alcohol consumption on clinical symptoms in a cohort Progressive supranuclear palsy (PSP) patients. Methods We conducted cross‐sectional study focusing possible and probable PSP patients Qilu Hospital Shandong University. Diagnoses phenotypes were confirmed using 2017 Movement Disorder Society criteria Multiple Allocations eXtinction (MAX) rules. Data drinking habits demographics collected via face‐to‐face interviews medical records reviews....