A5083048222- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Metabolism, Diabetes, and Cancer
- Nuclear Receptors and Signaling
- Lysosomal Storage Disorders Research
- Growth Hormone and Insulin-like Growth Factors
- Food Security and Health in Diverse Populations
- Botulinum Toxin and Related Neurological Disorders
- Heart Rate Variability and Autonomic Control
- Cellular transport and secretion
- Peptidase Inhibition and Analysis
- Diabetes Treatment and Management
- Neurological and metabolic disorders
- Protease and Inhibitor Mechanisms
- Child Nutrition and Water Access
- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- S100 Proteins and Annexins
- Vestibular and auditory disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Aortic Thrombus and Embolism
Karolinska Institutet
2016-2025
Centre for Palaeogenetics
2019-2024
John Wiley & Sons (United States)
2023
Prolepsis Institute
2017-2020
National and Kapodistrian University of Athens
2003-2019
Sotiria General Hospital
2019
Athens Medical Center
2018
St Savas Hospital
2018
Red Cross Hospital
2018
Karolinska University Hospital
2009-2013
Abstract Background There is a need for biomarkers to support an accurate diagnosis of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) has been successful biofluid finding neurodegenerative biomarkers, and modern highly sensitive multiplexing methods offer the possibility perform discovery studies. Using large-scale multiplex proximity extension assay (PEA) approach, we aimed discover novel diagnostic protein allowing discrimination PD from both controls atypical Parkinsonian disorders...
PURPOSE: To evaluate and quantify the association between consumption of specific food groups/macronutrients concentrations serum insulin-like growth factor 1 (IGF-1) factor–binding protein 3 (IGFBP-3). SUBJECTS AND METHODS: Data from a comprehensive food-frequency questionnaire administered to 115 healthy subjects were used study cross-sectionally relationship nutritional factors circulating IGF-1 IGFBP-3 concentrations. Adjustment for effect total energy intake series epidemiologic...
PURPOSE: Insulin-like growth factor (IGF-1) and its major binding protein (IGF-BP3) have recently been implicated in the pathogenesis of several malignancies. However, anthropometric lifestyle predictors these hormones not elucidated. Here we report results a cross-sectional study. SUBJECTS AND METHODS: This study examines relationship series epidemiologic parameters (age, sex, height, body mass index, smoking, alcohol consumption, coffee drinking) with IGF-1 IGF-BP3 sample 130 healthy...
Visual and oculomotor problems are very common in Parkinson's disease (PD) by using eye-tracking such could be characterized more detail. However, is not part of the routine clinical investigation parkinsonism.To evaluate gaze stability pupil size stable light conditions, as well eye movements during sustained fixation a population PD patients healthy controls (HC).In total, 50 (66% males) with unilateral to mild-to-moderate (Hoehn & Yahr 1-3, Schwab England 70-90%) 43 HC (37% were included...
Abstract Objective Decreased amyloid beta (Aβ) 42 together with increased tau and phospho‐tau in cerebrospinal fluid (CSF) is indicative of Alzheimer’s disease (AD). However, the molecular pathophysiology underlying slowly progressive cognitive decline observed AD not fully understood it known what other CSF biomarkers may be altered early stages. Methods We utilized an antibody‐based suspension bead array to analyze levels 216 proteins from patients, patients mild impairment (MCI), controls...
Abstract Background The interplay between glycemic control and Parkinson's disease (PD) has long been recognized but not fully understood. Objectives To investigate the association of glycated hemoglobin (HbA1c) levels with motor cognitive symptom progression in a prospective PD cohort. Methods Of 244 patients, 17 had low HbA1c (≤30 mmol/mol), 184 were euglycemic (HbA1c 31–41 18 high (HbA1 ≥42 25 diabetes mellitus (DM). Survival analysis was applied on time until Hoehn Yahr stage ≥3 (motor...
Abstract Background Levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD) is associated with ‘false neurotransmitter’ release of dopamine from serotonin (5‐HT) neurons. NLX‐112 a first‐in‐class, highly selective 5‐HT 1A receptor agonist which counteracts LIDs experimental PD models. Objectives The primary objective was to evaluate the safety and tolerability compared placebo people PD. secondary assess preliminary efficacy reducing LID its effects on symptoms. Methods Participants...
Introduction Determining the prevalence of large vessel occlusions (LVOs) is important for planning and accessing mechanical thrombectomy treatment. Previous estimates vary greatly in studies, which might be related to different inclusion criteria and/or selection bias. In this cohort study, we aimed determine presence LVO an unselected, i.e., untriaged, hospital-based stroke Sweden. Methods Stroke patients treated at Karolinska Huddinge University Hospital were consecutively collected...
Abstract Background Alteration in glycosphingolipids (GSLs) Parkinson's disease (PD) still needs to be determined. Objectives We evaluated if PD subjects show abnormal GSLs levels compared healthy controls (HC) and correlate with clinical features. Methods analyzed glucosylceramide (GlcCer) plasma using two normal‐phase high‐performance liquid chromatography assays; clinico‐demographic data were extracted. Results Eighty 25 HCs analyzed. Levels of GlcCer, GD1b, Gb4, GalNAcGA1, b‐series...
Abstract Background Cognitive impairment is common in patients with PD. Core markers of Alzheimer's dementia have been related also to PD dementia, but no disease‐specific signature predict exists date. Objectives The aim this study was investigate CSF associated cognition early Methods A high‐throughput suspension bead array examined 216 proteins 74 the AETIONOMY project. function assessed Repeatable Battery for Assessment Neuropsychological Status, Montreal Assessment, and Mini‐Mental...
admission hyperglycaemia (HG) is associated with worse prognosis and higher mortality within 3 months after stroke. Reports on long-term are inconsistent.to evaluate the influence of HG [blood glucose (BG) levels >8 mmol/L] ischaemic stroke (IS) transient attack (TIA).consecutive patients IS or TIA, admitted from January 1997 until December 2002, were retrospectively screened. BG was measured days onset symptoms. Information date death obtained 10 years onset.a total 509 (78% IS; 22% TIA)...
<b><i>Background:</i></b> Ischemic cerebrovascular disease (ICVD) comprises multiple etiological phenotypes that share common clinical characteristics. Etiological classification of patients with ICVD is major interest to achieve optimal medical treatment and predict prognosis. The TOAST system has been widely used describe stroke etiology but provides restricted phenotypic homogeneity within groups. ASCO introduced a new approach in classification, aims...
Reading difficulties are commonly reported in Parkinson's disease (PD). So far, only a few studies have assessed reading PD, most of them confirming different pattern patients compared with healthy populations. Impaired oculomotor control is an early feature PD. Cognitive deficits, on the other hand, may appear early, but they prominent at later stages. Although these two factors thought to be responsible for alterations performance, it unclear how each factor contributes them.To evaluate...
Type 2 diabetes mellitus and Parkinson’s disease are chronic diseases linked to a growing pandemic that affects older adults causes significant socio-economic burden. Epidemiological data supporting close relationship between these two aging-related have resulted in the investigation of shared pathophysiological molecular mechanisms. Impaired insulin signaling brain has gained increasing attention during last decade been suggested contribute development through dysregulation several...
Trypsin and its specific inhibitor, TATI (tumour-associated trypsin inhibitor), are expressed in normal human pancreas a variety of tumours. The aim the present study was to assess parallel expression colorectal cancer, comparison with their epithelial tissue, since proteases inhibitors thought be co-expressed malignant neoplasms. We also assessed possible significance as means differentiation between tissue. examined qualitatively semi-quantitatively immunohistochemical on paraffin-embedded...
The HYPEDIA study aimed at evaluating the implementation of 2018 European guidelines for treating hypertension in primary care. A nationwide prospective non-interventional cross-sectional was performed consecutive untreated or treated hypertensives recruited mainly care Greece. Participants' characteristics, office blood pressure (BP) (triplicate automated measurements, Microlife BPA3 PC) and treatment changes were recorded on a cloud platform. total 3,122 patients (mean age 64 ± 12.5 [SD]...