A5090984249- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Renal function and acid-base balance
- Childhood Cancer Survivors' Quality of Life
- Sirtuins and Resveratrol in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- Erythrocyte Function and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Pharmaceutical and Antibiotic Environmental Impacts
- Mitochondrial Function and Pathology
- Neonatal Health and Biochemistry
- Aquatic Ecosystems and Phytoplankton Dynamics
- Pesticide and Herbicide Environmental Studies
City of Hope
2024
Beckman Research Institute
2024
University of Padua
2010-2012
AREA Science Park
2009
Sirtuins (SIRTs) are NAD(+)-dependent deacetylases that regulate metabolism and life span. We used peripheral blood mononuclear cells (PBMCs) to determine ex vivo whether insulin resistance/metabolic syndrome influences SIRTs. also assessed the potential mechanisms linking metabolic alterations SIRTs in human monocytes (THP-1) vitro.SIRT1-SIRT7 gene protein expression was determined PBMCs of 54 subjects (41 with normal glucose tolerance 13 syndrome). Insulin sensitivity by minimal model...
The aim of this study was to evaluate the effect and molecular mechanism albumin infusion on cardiac contractility in experimental cirrhosis with ascites. Cardiac recorded ex vivo rats ascites control after injection caudal vein albumin, saline, or hydroxyethyl starch (HES). Gene protein expression β-receptors pathways involved their intracellular signaling such as Gα(i2) (Gα(i2)), adenylate cyclase 3 (Adcy3), tumor necrosis factor alpha (TNF-α) inducible nitric oxide synthase (iNOS), were...
Sex influences many biological outcomes, but how sex affects hematopoietic stem cell (HSC) aging and hematological disorders is poorly understood. The widespread use of young animal models to study age-related diseases further complicates these matters. Using aged long-lived BALB/c mouse models, we discovered that mice exhibit sex-dependent disparities, mirroring humans, in developing myeloid skewing, anemia, leukemia. These disparities are underlined by sex-differentiated HSC...