A5041876075- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Animal health and immunology
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Neurological diseases and metabolism
- Helminth infection and control
- Prion Diseases and Protein Misfolding
- Parasitic Infections and Diagnostics
- Veterinary Oncology Research
- Genetic and phenotypic traits in livestock
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Clostridium difficile and Clostridium perfringens research
- Coccidia and coccidiosis research
- Toxoplasma gondii Research Studies
- Respiratory viral infections research
- Veterinary Equine Medical Research
- Agriculture and Farm Safety
- Animal Nutrition and Physiology
- Cell Adhesion Molecules Research
- Viral-associated cancers and disorders
Scotland's Rural College
2017-2023
Scottish Agricultural Science Agency
2020
Friedrich-Loeffler-Institut
2019
University of California, Davis
2019
Animal and Plant Health Agency
2011-2016
Département Santé Animale
2012
IDEXX Laboratories (Germany)
2012
Vitenparken
2007-2010
European Willow Breeding (Sweden)
1997-1998
University of Liverpool
1993-1997
In June 2013, a 4-year-old Welsh Mountain ewe and in March 2014 10-day-old lamb of the same breed flock presented progressive neurological signs including depressed sensorium, tremor, unusual behaviour. Neuropathological examination brain spinal cord detected non-suppurative polioencephalomyelitis dorsal root ganglionitis, characteristic neurotropic viral agent both sheep. Metagenomic analysis different tissue samples from animals identified novel Ovine Astrovirus (OvAstV). The presence...
Ileal biopsies were obtained from 18 horses with grass sickness, 15 other alimentary disease and three without gastrointestinal disease. Samples of small intestine also nine cases obstruction due to intestinal strangulation. Histological examination revealed that severe enteric neuropathy in the absence significant morphological changes was confined sickness.
Beginning in 2002, a small number of pig farms western Canada began reporting 4–7-week-old pigs with bilateral hind-end paresis or paralysis. Low numbers were affected, some died, most had to be euthanized, and those that survived reduced weight gains neurological deficits. Necropsies revealed no gross lesions, but microscopic lesions consisted nonsuppurative polioencephalomyelitis, severe the brain stem spinal cord. The consistent viral infection. Tests for circovirus, Porcine reproductive...
The degeneration of enteric neurones has been recorded in grass sickness, but the distribution lesions gut and their possible relationship with severity clinical signs not established. Samples obtained from 11 anatomically defined sites along gastrointestinal tract eight control horses without disease, five acute sickness three chronic were examined histologically. organisation ganglia was similar to that other large mammalian species. Minor exceptions included presence fundic mucosal nerve...
A 6-month-old dairy heifer calf with no premonitory signs was acutely down after the morning feeding and could not rise. On presentation, in right lateral recumbency moribund opisthotonus left hind limb paddling. Following euthanasia, gross examination of brain revealed multifocal loss gray-white matter distinction extensive petechiae throughout brainstem. histopathological examination, there striking white edema marked perivascular proteinaceous surrounding many arterioles venules...
Porcine circovirus types 1 (PCV1) and 2 (PCV2) have been associated with congenital tremors (CTs) in piglets the United States. In this study, central nervous system nonneural tissues of 40 CT from Spain, Kingdom, Ireland, Sweden were investigated for presence PCV1 PCV2 using situ hybridization immunohistochemical labeling on paraffin sections. The polymerase chain reaction was also carried out sera Spanish cases. No evidence nucleic acid or antigen found any piglet. Although these results...
Fell pony foals developed a syndrome of anaemia, immunodeficiency and peripheral ganglionopathy. They became ill in the second or third week, died month life. Clinical pathological investigations revealed severe anaemia associated with small numbers late erythroid precursors bone marrow, thymi, an absence secondary lymphoid follicles, lack plasma cells neuronal chromatolysis involving trigeminal, cranial mesenteric dorsal root ganglia. Some had cryptosporidial enteritis adenoviral...
This paper presents data from 23 British herds investigated between 1991 and 2007 where neurological disease in calves was caused by bovine viral diarrhoea virus (BVDV) infection. A variety of clinical signs, most commonly tremor or trembling, were apparent the birth, recumbent unable to stand unsupported. Severe diffuse neuraxial hypomyelination present all calves, immunohistochemistry revealed cerebral neuronal labelling consistent with congenital persistent pestivirus infection each...
Between January and April 1995, the brains hearts of 281 aborted lambs derived from 209 submissions to veterinary investigation centres in England Wales were examined histologically. One-hundred-and-seventy-nine samples fetal pleural fluid these 141 not histologically for antibodies Neospora by an indirect fluorescent antibody test. Non-suppurative myocarditis encephalitis present nine lambs. Immunocytochemistry using antisera against caninum Sarcocystis species resulted no labelling but...
An indirect fluorescent antibody test was applied to sera from normally calving and aborting cows samples of pleural fluid their aborted calves, the titres were compared with histology immunocytochemistry for diagnosis Neospora ‐associated abortion. Two groups a third group which had calved used; A consisted 36 calves showing characteristic non‐suppurative inflammatory lesions in demonstrated by immunocytochemistry, B 100 without histological evidence neosporosis, C 128 sampled within one...
Postmortem examinations of four pine martens which had died as a result road accidents in Scotland revealed focal, granulomatous lesions the heart and skeletal muscles three them. An immunoperoxidase staining technique showed that were due to infection with Hepatozoon species. A PCR-based assay was used confirm presence DNA infected tissues. The nucleotide base sequence PCR products suggested infecting organism probably new species Hepatozoon, most closely related to, but distinct from,...
Summary Reasons for performing study Equine grass sickness ( EGS ) is of unknown aetiology. Despite some evidence suggesting that it represents a toxico‐infection with Clostridium botulinum types C and/or D, the effect on functional targets neurotoxins, namely soluble N‐ethylmaleimide‐sensitive factor attachment receptor SNARE proteins, unknown. Further, while commonly stated that, unlike , equine botulism not associated autonomic and enteric neurodegeneration, this has been definitively...
ABSTRACT Histiocytic ulcerative colitis is an uncommon cause of canine large bowel diarrhoea that generally refractory to standard treatment for idiopathic colitis. It characterised pathologically by mucosal ulceration with a mixed inflammatory cell infiltrate, in which periodic acid‐Schiff positive histiocytes are dominant feature. The disease well recognised young boxer dogs the USA, Australasia and mainland Europe. This paper reports occurrence seven cases histiocytic seen recently UK,...
Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly bleeding calf syndrome) is a novel disease of young calves which has emerged in number European countries during recent years. Data were retrospectively collected June to November 2010 for 56 case diagnosed with BNP between 17 March 7 the same year. These compared 58 control randomly recruited from herds no history BNP. Multivariable logistic regression analysis showed that increased odds...
Abstract Using metagenomic analysis, we identified a novel picornavirus in young preweaned lambs with neurologic signs associated severe nonsuppurative encephalitis and sensory ganglionitis 2016 2017 the United Kingdom. In situ hybridization demonstrated intralesional neuronotropism of this virus, which was also detected archived samples similarly affected (1998–2014).