A5102753424- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Advanced biosensing and bioanalysis techniques
- Dengue and Mosquito Control Research
- Nanoparticles: synthesis and applications
- Insect symbiosis and bacterial influences
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- 2D Materials and Applications
- SARS-CoV-2 detection and testing
- Helminth infection and control
- Neuroscience and Neural Engineering
- Metabolomics and Mass Spectrometry Studies
- Topological Materials and Phenomena
- Railway Engineering and Dynamics
- Malaria Research and Control
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Vibration and Dynamic Analysis
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene research and applications
- Luminescence and Fluorescent Materials
- Parasite Biology and Host Interactions
Universität Hamburg
2019-2025
Shenzhen Center for Disease Control and Prevention
2017-2025
Jinan University
2024
Yangzhou University
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2024
Guangzhou University of Chinese Medicine
2023-2024
Southern University of Science and Technology
2024
City University of Hong Kong
2023
Hubei University of Technology
2023
Hunan University of Traditional Chinese Medicine
2022-2023
Sensitive and accurate detection of highly contagious virus is urgently demanded for disease diagnosis treatment. Herein, based on a multifunctional aggregation-induced emission luminogen (AIEgen), dual-modality readout immunoassay platform ultrasensitive viruses has been successfully demonstrated. The relied virions immuno-bridged enzymatic hydrolysis AIEgen, accompanying with the in situ formation emissive AIE aggregates shelling silver gold nanoparticles. As result, robust turn-on...
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques the life sciences medicine, however, has not yet been fully exploited. We highlight current upcoming advances this direction. describe different methodologies (including those performed at synchrotron light sources X-ray free-electron lasers) their potentials for application to investigate nano–bio interface. discussion is...
Abstract RNA aptamers provide useful biological probes and therapeutic agents. New methodologies to screen will be valuable by complementing the traditional Systematic Evolution of Ligands Exponential Enrichment (SELEX). Meanwhile, repurposing clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated systems (Cas) has expanded their utility far beyond native nuclease function. Here, CRISmers, a CRISPR/Cas‐based novel screening system for based on binding chosen...
Aims: The screening and diagnosis of dengue virus infection play a crucial role in controlling the epidemic fever, highlighting urgent need for highly sensitive, simple, rapid laboratory testing method. This study aims to assess clinical performance MAGLUMI Denv NS1 detecting antigen. Methods: A retrospective was conducted sensitivity specificity using residual samples. Dengue-confirmed excluded samples, validated by qPCR, were subjected with accordance manufacturer’s instructions. linear...
The gene therapy attracted more and attention for the tumor therapy. To obtain a safe system, new vectors beyond virus were developed high efficiency. ultrasound mediated was safer plasmid DNA could be delivered by microbubbles combined with to increase transfection In this work, cationic decorated Cyclo(Cys-Arg-Gly-Asp-Lys-Gly-Pro-AspCys) (iRGD peptides) magnetic Fe3O4 nanoparticles (MBiM) designed targeted contrast imaging guided of tumors. image intensity dramatically enhanced at site...
Coronavirus Disease 2019 (COVID-19) has become a worldwide pandemic and affected more than 227 countries or territories, resulting in 25 million cases with over 0•85 deaths, as of September 2, 2020. Taiwan been successful countering the COVID-19 outbreak, however, potential risk for asymptomatic infections prevalence rates remain unknown. We aimed to estimate seroprevalence via serologically testing hospital patients neither symptoms indicative nor positive nucleic acid test SARS-CoV-2...
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus within the family Togaviridae, which has attracted global attention due to its recent re-emergence. In one of our previous studies, we successfully isolated two CHIKV strains, SZ1050 and SZ1239, from serum samples imported patients in 2010 2012, respectively. However, differences their genome characters cell tropisms remain undefined.We extracted RNA isolates performed PCR determine sequence whole viral genomes. The genotypes...
Sensitive and accurate diagnosis of viral infection is important for human health social safety. Herein, by means explosive catalysis from an enzyme muster, a powerful naked-eye readout platform has been successfully constructed ultrasensitive immunoassay entities. Liposomes were used to encapsulate multiple enzymes into active unit. In addition, its triggered rupture could boost the disassembly gold nano-aggregates that cross-linked peptides with opposite charges. As result, plasmonically...
Two health concerns primarily related to triatomine bugs are transmission of Trypanosoma cruzi through infective feces, and allergic reactions induced by bites. In the Southwestern United States, reduviid bites commonly cause insect allergy. South China, four cases anaphylactic shock have been reported after this bite exposure. To further classify species these confirm sensitization saliva, we caught from region where occurred performed phylogenetic immunohistochemical (IHC) analysis....
Dengue fever is the most common arbovirus in world, and all four serotypes are infectious pathogenic, but dengue virus (DENV)-1 DENV-2 prevalent Guangdong Province. To investigate differences serotypes, we evaluated replication, pathogenicity, NS1 expression of DENV-3 cells, further investigated effects on viral replication transmission. The results this study indicated that replicated faster was more pathogenic than DENV-3. In Vero secreted protein DENV-3, promoted infection Aedes...
Clonorchis sinensis is an important foodborne zoonosis worldwide and prevalent in China for more than 2000 years. According to the experience of controlling Schistosoma japonica, started establish integrated control strategy C. endemic areas. Lou village, largest village Shenzhen city South was taken as a pilot site. This longitudinal study assessed infection status among people intermediate hosts from 2006 2014 village. After continuous intervention with strategy, prevalence decreased...
Direct mass spectrometry (MS) analysis of human tissue at the molecular level could gain insight into biomarker discovery and disease diagnosis. Detecting metabolite profiles sample play an important role in understanding pathological properties development. Because complex matrices samples, complicated time-consuming preparation processes are usually required by conventional biological clinical MS methods. with ambient ionization technique is a new analytical strategy for direct little...
There have been many studies on the motion and aggregation characteristics of fiber impurities in insulation oil under static conditions. However, there are few flow In large power transformers, is constantly a state flow. As result, suspended even more complex due to effects This study constructed multiphysics field model for single-particle fibrous solid–liquid two-phase systematically analyzed its characteristics. The shows that collision frequency between impurity particles electrodes...
Cu-bearing antibacterial martensitic stainless steel (MSS) has a broad application prospect in cutting field, which needs combination of good property and high hardness. In this work, 420Cu (SS) with Cu addition different austenitizing temperatures were investigated to address the above issue. The results plate count measurement biofilm observation indicated that SS austenitized at lower temperature shows better performance. Rockwell hardness was up 52.7 HRC corrosion resistance evaluated by...
Abstract Most studies about the interaction of nanoparticles (NPs) with cells have focused on how physicochemical properties NPs will influence their uptake by cells. However, much less is known potential excretion from to control and manipulate number in a cell, both cellular must be studied quantitatively. Monitoring intracellular extracellular amount over time (after residual noninternalized been removed) enables one disentangle influences cell proliferation exocytosis, major pathways for...
Background: Type 2 diabetes (T2D) is a prevalent chronic disease with elusive. Combining transcriptome and single-cell sequencing data to explore biomarkers of T2D could provide new insights into the in-depth understanding molecular mechanisms diagnosis T2D. Methods: The GSE41762 dataset including RNA-seq for healthy patients, was obtained from Gene Expression Omnibus (GEO) database. potential functions differentially expressed genes (DEGs) were revealed by Ontology (GO) Kyoto Encyclopedia...
With the aid of nanoscopic Raman spectroscopy, we track interaction between injected hot electrons and phonons in Bi 2 Se 3 nanoribbon.