A5085539440- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Influenza Virus Research Studies
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Cardiac Valve Diseases and Treatments
- Pediatric health and respiratory diseases
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Mosquito-borne diseases and control
- Autoimmune and Inflammatory Disorders Research
- Infectious Diseases and Tuberculosis
- COVID-19 Impact on Reproduction
- Congenital Heart Disease Studies
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
Hallym University Sacred Heart Hospital
2020-2025
Hallym University
2024-2025
Southwestern Medical Center
2024
The University of Texas Southwestern Medical Center
2023-2024
Seoul St. Mary's Hospital
2023
Catholic University of Korea
2023
Myongji Hospital
2022
Hanyang University
2022
Ewha Womans University
2011-2020
Handong Global University
2019
Coronavirus disease-2019 (COVID-19), which started in Wuhan, China, December 2019 and declared a worldwide pandemic on March 11, 2020, is novel infectious disease that causes respiratory illness death. Pediatric COVID-19 accounts for small percentage of patients often milder than adults; however, it can progress to severe some cases. Even neonates suffer from COVID-19, children may spread the community. This review summarizes what currently known about adolescents.
Abnormal angiogenesis is a primary cause of many eye diseases, including diabetic retinopathy, age-related macular degeneration, and retinopathy prematurity. Mesenchymal stem cells (MSCs) are currently being investigated as treatment for several such retinal diseases based on their neuroprotective angiogenic potentials. In this study, we evaluated the role systemically injected human placental amniotic membrane-derived MSCs (AMSCs) pathological neovascularization proliferative retinopathy....
Patients with systemic lupus erythematosus (SLE) are susceptible to infectious diseases owing various immunosuppressive treatments and disease characteristics. Meningococcal infections progress rapidly a high incidence of severe complications mortality; therefore, meningococcal vaccination is needed. However, there limited evidence regarding the immunity immunogenicity patients SLE. This study aimed analyze serum bactericidal activity against meningococci in SLE two domestic institutions...
Background Staphylococcus pseudintermedius is a Gram‐positive bacteria that colonizes the skin and orifices of healthy canines felines. It has recently been identified as cause sinonasal infections in humans. Methods This study was retrospective review chronic rhinosinusitis (CRS) patients with S ‒positive cultures comparison to prospectively collected control sample who underwent culture for acute exacerbation CRS. Results Thirty‐three CRS had nasal positive . Of cultures, 82% demonstrated...
Purpose To examine the relationship between menarcheal age and anthropometric indices menstrual irregularity in late adolescent girls Seoul. Methods We surveyed 4,218 fertile ages of 16 18 years to determine their age. Measurements were taken from June 2008 October 2009 at seven girl's high schools Seoul, Korea. Participants offered self-report questionnaire as a survey tool that included questions on (height, weight, waist circumference), age, pattern, frequency menstruation per year....
2019년 12월 발견되어 2020년 3월 11일 전 세계 대유행이 선포된 코로나바이러스감염증-2019 (coronavirus disease-2019, COVID-19)는 신종 감염병으로서 수많은 감염사례와 사망을 초래하여 사회 전반적으로 영향을 끼치고 있다. 소아청소년 COVID-19는 발병 환자 중 차지하는 비율이 적으며 성인보다는 경증인 경우가 많으나, 일부에서는 중증으로 진행할 수 신생아 시기부터 감염될 있으며, 지역사회 감염의 전파자로서 역할을 할 있을 것으로 보인다. 본 종설에서는 현재까지 소아청소년에서의 COVID-19에 대해 알려진 내용을 정리하여 환자들의 진료에 도움을 주고자 한다.
Cross-reactivity of pneumococcal capsular polysaccharides is a key element for formulating vaccines and evaluating vaccine efficacy. This study examined whether 23-valent polysaccharide (PPSV23), which only contains 6B, can elicit cross-functional immune responses against recently discovered serotypes (6C 6D), as well 6A, in 2 adult age groups.Young adults (25-51 years; N = 28) elderly subjects (over 65 60) were immunized with PPSV23. Functional antibody determined pre- postimmune sera via...
In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). protein DC and production pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-<TEX>${\alpha}$</TEX>, IL-<TEX>$1{\beta}$</TEX>) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. activates phosphorylation MAPKs, such as ERK, p38MAPK, JNK, which...
Antibodies against Hepatitis A and B Virus in Intravenous Immunoglobulin ProductsThe worldwide seroprevalence of hepatitis virus (HAV) (HBV) has changed over the last two decades, indicating a declining incidence HAV HBV infections.Therefore, vaccinations are recommended for unimmunized people before traveling to an endemic area.Unfortunately, primary antibody deficiency (PAD) patients can only obtain humoral immunity through intravenous immunoglobulin G (IVIG) replacement not from...
Herpes zoster (HZ) is caused by latent varicella-zoster virus (VZV) reactivation when VZV-specific cell-mediated immunity declines. Information on HZ in children limited. Therefore, we retrospectively investigated HZ's clinical course and complications children. We extracted the outpatient hospitalization medical records of pediatric patients (<19 years) primarily diagnosed with (ICD-10 B02 code) between January 2010 November 2020. was defined as a typical unilateral dermatomal vesicular...
The meningococcus carriage rate is age-dependent, with a high prevalence in adolescents and young adults. This cross-sectional study aimed to estimate the oropharyngeal of among healthy Korean its relationship several population characteristics. survey was conducted from April May 2015 1,460 first-year high-school students 9 schools located Gyeonggi province, Korea. Each student answered short questionnaire assessing risk factors for carriage, posterior pharyngeal wall swab samples were...
Abstract Background: Although MMR vaccine is widely used in Korea, there are limited studies on the currently vaccines. We evaluated immunogenicity and safety of vaccines Korean children. Methods: For first second dose immunization, children aged 12–23 months 4–6 years were enrolled. All subjects received a single either Priorix™ (Glaxo Smithkline Biologicals, Rixensart, Belgium) or MMRII® (Merck & Co., Inc., West Point, PA, USA). Pre‐ postvaccine sera collected from all participants....
Intravenous immunoglobulin G (IVIG) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (PAD). However, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause infection PAD. In this study, functional Haemophilus influenzae type b (Hib), Streptococcus pneumoniae (pneumococci), and Neisseria meningitidis (meningococci) IVIG were evaluated.Sixteen lots of products prepared by two Korean...
The pneumococcal capsule is indispensable for pathogenesis in systemic infections; however, many diseases, including conjunctivitis, otitis media, and some infections immunocompromised patients, are caused by nonencapsulated Streptococcus pneumoniae (NESp). Null clade 1 (NCC1), found group 2 NESp, expresses surface protein K (PspK) becoming prevalent among organisms owing to the widespread use of conjugate vaccines. Despite its clinical importance, molecular mechanisms underlying prevalence...
The protective capacities of antibodies induced with Haemophilus influenzae type b (Hib) vaccines can be directly assessed in vitro a Hib-specific serum bactericidal assay (SBA). However, the conventional SBA requires several tedious steps including manual counting bacterial colonies, and therefore, it is seldom used.To overcome these limitations, we have improved by using frozen target bacteria developing an automated colony method based on agar plates chromogenic dye 2, 3, 5-triphenyl...
Seroprevalences of Specific IgG Antibodies to Measles, Mumps, and Rubella in Korean InfantsIn this study, the seroprevalences measles, mumps, rubella antibodies infants were determined assess immunization strategy control measures for these infectious diseases.Serum samples from < 1 year age their mothers collected measure concentrations specific by enzyme-linked immunosorbent assay.For selected infant serum samples, measles-specific neutralizing antibody levels using plaque reduction...
Reappraisal of the Immunogenicity and Safety Three Hepatitis A Vaccines in AdolescentsAlthough overall incidence hepatitis Korea has been decreasing, adolescents remain highly vulnerable to its outbreaks.This study was conducted compare immunogenicity safety three vaccines Korean adolescents.Healthy anti-hepatitis virus seronegative subjects aged 13 19 yr were randomized equal groups receive two doses Avaxim TM , Epaxal®, or Havrix®, 6 12 months apart.Seroconversion rates one month after...
대한소아감염학회와 질병관리본부 중앙방역대책본부는 소아청소년 코로나바이러스감염증-19 (coronavirus disease 2019, COVID-19) 대응지침을 발표하였다. 사례정의 및 조치사항을 신생아, 영아, 소아청소년에 맞추어 정리하였으며, 보호자 관리에 대한 지침을 마련하였다. 본 종설에서는 우리나라 COVID-19 대응지침의 내용을 소개하고자 한다.
Neisseria meningitidis is a leading global cause of bacterial meningitis and sepsis. 1,2Permanent disability or death can occur within few hours symptom onset, morbidity mortality rates are high. 3An estimated 500000 annual cases meningococcal disease worldwide, with case fatality rate 10-15%. 4The greatest burden occurs between the ages six months two years, but second peak among adolescents young adults. 2In particular, new military recruits college freshmen living in dormitories have been...
Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality globally. PTB rates have increased in South Korea despite reduction rates. A history strong predictor subsequent screening cervical length between 16 0/7 weeks 24 gestation recommended women with singleton pregnancy prior spontaneous PTB. However, the prediction prevention PTBs without remain matter debate. The scope this review article comprises strategies for asymptomatic PTB, based on recent evidence guidelines.
Hepatitis A can cause serious illness among adolescents and adults with low vaccination coverage. Even though hepatitis vaccine is one of the strong candidates for Korean national immunization program, aged older than 12 yr would not benefit. Our purpose was to assess willingness analyze correlates mothers (HepA) develop strategies HepA vaccination. telephone survey on 800 children 7-18 conducted random-digit dialing method. Sixty-two percent 92% reported that they were willing at current...