A5082525513- Tuberculosis Research and Epidemiology
- Adenosine and Purinergic Signaling
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Mosquito-borne diseases and control
- Travel-related health issues
- Mycobacterium research and diagnosis
- Malaria Research and Control
- Viral Infections and Vectors
- Trypanosoma species research and implications
- Viral Infections and Outbreaks Research
- HIV/AIDS Research and Interventions
- Dialysis and Renal Disease Management
- Immune responses and vaccinations
- Infectious Diseases and Tuberculosis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neurological Complications and Syndromes
- Hepatitis C virus research
- Disaster Response and Management
- Neuroscience of respiration and sleep
- HIV, Drug Use, Sexual Risk
- Nitric Oxide and Endothelin Effects
- Diabetes Treatment and Management
- Pneumonia and Respiratory Infections
- Calcium signaling and nucleotide metabolism
James Cook University
2018-2024
Västerås Municipality
2022
University Hospital of Zurich
2014-2018
University of Zurich
2015-2018
Australian Institute of Tropical Health and Medicine
2018
Swiss Tropical and Public Health Institute
1999-2015
Ifakara Health Institute
2013-2015
Makerere University
2015
Infectious Diseases Institute
2015
Swiss School of Public Health
2015
Journal Article Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study Get access A. Färnert, Färnert ∗ aDivision Infectious Diseases, Department Medicine, Karolinska Institutet, Huddinge University Hospital, 14186 Huddinge, SwedenbDivision 17176 Stockholm, Sweden ∗Address for correspondence: Anna Division S-171 76 Sweden; phone +46 8 51771861 or 51773358, fax 51771806. anna.farnert@medks.ki.se Search other works this author on: Oxford Academic PubMed Google...
Around 3.3 million children worldwide are infected with HIV and 90% of them live in sub-Saharan Africa. Our study aimed to estimate adherence levels find the determinants, facilitators barriers ART among teenagers rural Tanzania. We applied a sequential explanatory mixed method design targeting aged 2–19 years residing Ifakara. conducted quantitative cross sectional followed by qualitative combining focus group discussions (FGDs) in-depth interviews (IDIs). used pill count measure defined...
Several studies suggest that in individuals with substantial previous exposure to malaria, co-infection multiple clones of Plasmodium falciparum can protect against subsequent clinical malaria attacks. Other studies, mainly little exposure, found the converse relationship. To test whether acquisition such cross-protection tracks immunity general, 610 Tanzanian children aged 0–6 years were enrolled a nine-month prospective study risk morbidity relation parasitological status and merozoite...
The relationship between concentrations of antituberculosis drugs, sputum culture conversion, and treatment outcome remains unclear. We sought to determine the association drug conversion among patients coinfected with tuberculosis human immunodeficiency virus (HIV) receiving first-line drugs. enrolled HIV-infected Ugandans pulmonary tuberculosis. Estimation was performed 1, 2, 4 hours after intake at 8, 24 weeks treatment. Serial cultures were each visit. Time-to-event analysis used factors...
Co-infection with hepatitis B virus (HBV) is highly prevalent in people living HIV Sub-Saharan Africa. Screening for HBV surface antigen (HBsAg) before initiation of combination antiretroviral therapy (cART) recommended. However, it not part diagnostic routines programs many resource-limited countries although patients could benefit from optimized covering both infections. be facilitated by rapid tests HBsAg. Operating experience these point care devices HIV-positive Africa largely lacking....
Diadenosine polyphosphates have been demonstrated to be involved in the control of vascular tone as well growth smooth muscle cells and hence, possibly, atherogenesis. In this study we investigated question whether diadenosine are present human plasma a potential source can identified that may release into circulation.Plasma (ApnA with n=3 6) were purified homogeneity by affinity-, anion exchange-, reversed phase-chromatography from deproteinized plasma. Analysis homogeneous fractions...
Diadenosine pentaphosphate and diadenosine hexaphosphate have been isolated in human platelets postulated to play an important role the control of vascular tone. Here we describe isolation identification heptaphosphate from platelets. Dinucleoside polyphosphates were concentrated by affinity chromatography a nucleotide-containing fraction deproteinated purified anion-exchange reversed phase high performance liquid homogeneity. Analysis one these fractions with matrix-assisted laser...
Dinucleoside diphosphates, Ap(2)A, Ap(2)G, and Gp(2)G represent a new class of growth-promoting extracellular mediators, which are released from granules after activation platelets. The presence theses substances was shown purification platelet concentrate. were identified by UV spectrometry, retention time comparison with authentic substances, matrix-assisted laser desorption/ionization mass post-source-decay enzymatic analysis. have growth-stimulating effects on vascular smooth muscle...
Phenylacetic acid (PAA) is a recently described uremic toxin that inhibits inducible nitric oxide synthase expression and plasma membrane calcium ATPase may therefore also be involved in remodeling of arteries. Such vascular effects have not been evaluated yet patients with chronic kidney disease stage 5.We prospectively measured the concentrations PAA using nuclear magnetic resonance spectroscopy 50 5 (37 men, 13 women) on maintenance hemodialysis. Arterial properties were quantified by...
African animal trypanosomiasis (AAT) control programs rely on active case detection through the screening of animals reared in disease endemic areas. This study compared application polymerase chain reaction (PCR) and microscopy trypanosomes cattle blood Mambwe, a rural district eastern Zambia. Blood samples were collected from 227 tested for infection with using Ribosomal RNA Internal Transcribed Spacers (ITS)-PCR. Microscopy buffy coat detected 17 cases, whilst thin thick smears 26 cases...
Angiotensin II (Ang II) is the major vasoactive component of renin-angiotensin system. Several components system have been demonstrated in different tissues. Whereas roles tissue and renal studied detail, much less known on whether corpuscular elements circulating blood contribute to Ang production. Here we examined whether, addition vasculature, cells also levels. Mononuclear leukocytes were obtained from healthy subjects incubated. The resulting supernatant was chromatographed using...
In clinical neuropsychology, the present status of a patient is evaluated in relation to assumed premorbid status. However, Sweden, existing methods assess are far from optimal. study, design and evaluation Swedish Lexical Decision Test (SLDT) for global cognitive function (i.e., intelligence) described. The was based on empirical finding that, general adult population, word knowledge strongly associated with measures functioning. Linear stepwise regression analysis demonstrated that SLDT...
Human cystic echinococcosis (CE) is a parasitic infection caused by the larval stage of tapeworm Echinococcus granulosus sensu lato, primarily affecting liver and lungs. Although heart affected in only 0.02-2% all CE cases, considerable number cases have been, continue to be, published. However, due rare occurrence cardiac resulting lack clinical trials, knowledge about various aspects disease remains limited. To obtain clearer picture anatomical, clinical, diagnostic as well therapeutic CE,...
Significance Tuberculosis (TB) susceptibility and disease are significantly exacerbated in people with type 2 diabetes. The underlying mechanisms incompletely understood, it is not known if new TB vaccine candidates will be safe provide protection the context of Using a long-term diet-induced murine model diabetes, we demonstrate that increased to caused by impaired mycobacterial recognition killing diabetic lung. Importantly, show mucosal vaccination mice Bacillus Calmette–Guérin (BCG)...
Tuberculosis (TB) is a leading cause of death among people living with HIV in sub-Saharan Africa. Several factors influence the efficacy TB treatment by to suboptimal drug concentrations and subsequently affecting outcome. The aim this cohort determine association between anti-TB outcomes.Patients diagnosed new pulmonary at integrated TB-HIV outpatient clinic Kampala, Uganda, were enrolled into study started on first-line treatment.Between April 2013 2015, 268 patients coinfected TB/HIV ;...
Introduction There is limited data available on exposure to anti‐tuberculosis (TB) drugs in this region. Peloquin has described reference ranges [ 1 ] however some studies have demonstrated that patients actually achieve concentrations below these 2 ]. about anti‐TB the HIV/TB co‐infected population Sub‐Saharan Africa. Our objective describe concentration of drug levels a well characterized prospective cohort adult starting treatment for pulmonary TB. Methods This study an ongoing carried...