A5001821540- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Gastrointestinal motility and disorders
- Retinal and Macular Surgery
- Diet and metabolism studies
- Retinal Development and Disorders
- Urinary Bladder and Prostate Research
- Regulation of Appetite and Obesity
- Systemic Lupus Erythematosus Research
- Vagus Nerve Stimulation Research
- Biochemical Analysis and Sensing Techniques
- Cerebral Venous Sinus Thrombosis
- Drug-Induced Ocular Toxicity
- Pain Mechanisms and Treatments
- Gastroesophageal reflux and treatments
- Glioma Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Sleep and Wakefulness Research
- Food Drying and Modeling
- Microbial Inactivation Methods
- Homicide, Infanticide, and Child Abuse
- Brain Metastases and Treatment
University of California, Los Angeles
2023-2025
Institute for Research and Innovation in Biomedicine
2016-2023
Université de Rouen Normandie
2016-2023
Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
2020-2023
ADIR Association
2022-2023
Hôpital Paris Saint-Joseph
2022
University of Béjaïa
2022
Inserm
2016-2020
Normandie Université
2020
Institute for Biomedicine
2018
After myocardial infarction (MI), pathological autonomic remodeling, including vagal dysfunction and sympathoexcitation, occurs predisposes to ventricular arrhythmias (VT/VF). The underlying factors that drive this the observed neuroinflammation glial activation, remain unknown. We hypothesized sympathetic nociceptive afferents underlie remodeling post-MI. Epidural resiniferatoxin (RTX, ablate cardiac afferent neurons) vs. saline was administered in pigs prior MI electrophysiological effects...
<title>Abstract</title> After myocardial infarction (MI), pathological autonomic remodeling, including vagal dysfunction and sympathoexcitation, occurs predisposes to ventricular arrhythmias (VT/VF). The underlying factors that drive this the observed neuroinflammation glial activation, remain unknown. We hypothesized sympathetic nociceptive afferents underlie remodeling post-MI. Epidural resiniferatoxin (RTX, ablate cardiac afferent neurons) vs. saline was administered in pigs prior MI...
Abstract This investigation presented presents the drying characteristics, and aimed to predict kinetics of tomato slices ( Lycopersicon esculentum MILL.) using convection microwave methods. Hot air was carried out in a ventilated oven at 50, 60, 80, 100°C temperatures performed domestic 300, 500, 800, 900 W powers. Twenty‐two mathematical models were undertaken best model chosen based on highest R 2 values lowest root mean square error (RMSE) χ values. Drying kinetics, rate variation,...
In Brief Purpose: The purpose of this study was to analyze the angiographic (confocal scanning laser ophthalmoscopy technology) and corresponding (eye-tracked) spectral-domain optical coherence tomography (SD-OCT) features propose a classification for progressive phases establishing retinal–choroidal anastomosis (RCA). Methods: We reviewed all consecutive eyes with RCA that underwent Heidelberg Retina Angiograph angiography tracked Spectralis SD-OCT at University Eye Clinic Creteil between...
Sacral nerve stimulation (SNS) is a surgical treatment of fecal and urinary incontinence that consists inserting stimulating electrode into one the s3 or s4 sacral holes. In addition to benefit SNS in incontinence, recent studies showed effective irritable bowel syndrome as well bladder pain syndrome. The aim this study was evaluate effect on visceral mechanosensitivity cross-organ sensitization rat model.Hypersensitive model obtained by instillation acetic acid rats during 5 minutes, 30...
<b><i>Purpose:</i></b> To report unusual presentations of type 2A idiopathic macular telangiectasia (IMT). <b><i>Methods:</i></b> A retrospective analysis disease presentation was conducted in 32 patients with IMT. All underwent a complete ophthalmological examination, including spectral domain optical coherence tomography (SD-OCT), fluorescein angiography (FA) and indocyanine green (ICGA). <b><i>Results:</i></b> Three...
Abstract Ghrelin is the only orexigenic peptide currently known and a potent prokinetic by promoting gastric motility but novel insights suggest that its role extends beyond satiety regulation. Whereas ghrelin was shown to provide somatic colonic antinociception, impact on sensitivity unknown even though stomach major secreting tissue. Autonomic response mechanosensitivity estimated measuring blood pressure variation as surrogate marker in distension (GD) before after (or vehicle)...
In Brief Purpose: To determine the visual field patterns obtained by preferential hyperacuity perimetry (PHP) in patients with Best vitelliform macular dystrophy mutations BEST1 gene. Methods: Consecutive underwent a complete ophthalmologic examination, including functional assessment best-corrected acuity and Foresee PHP morphologic fundus biomicroscopy, autofluorescence, spectral-domain optical coherence tomography. The "PHP defect index" (which is max peak value of metamorphopsia [maximal...
Abstract APOLLON (NCT02924311) was a prospective observational study to evaluate the effectiveness of intravitreal aflibercept (IVT-AFL) treatment diabetic macular edema (DME) over 24 months in routine clinical practice France. The primary endpoint mean change from baseline best-corrected visual acuity (BCVA; Early Treatment Diabetic Retinopathy Study letters) by 12 months, and safety monitored throughout study. Of 402 patients enrolled across 61 participating clinics hospitals France, 168...
Irritable bowel syndrome and bladder pain often overlap are both characterized by visceral hypersensitivity. Since pelvic organs share common sensory pathways, it is likely that those syndromes involve a cross-sensitization of the colon. The precise pathophysiology remains poorly understood.To develop model chronic bladder-colon to investigate mech-anisms involved.Chronic cross-organ sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections acetic acid under...
Background: Chronic constipation (CC) is highly prevalent and affects approximately 15% of persons in the United States. Opioid-induced (OIC) particular, a significant complication affecting up to 80% non-cancer patients receiving opioids. Current treatments for CC suffer from adverse effects, poor compliance, low effcacy. Progress treatment hampered part by lack studies models higher translational value due limited means assess gut motility non-invasively. To palliate this of, we recently...
The central and peripheral nervous systems provide cholinergic innervation in the colon. ability to assess their neuroanatomical distinctions is still a challenge. pig regarded as relevant translational model due close similarity of its enteric system (ENS) with that human. Opioid-induced constipation one most common side effects opioid therapy.We developed an approach differentiate colon using double immunolabeling novel mouse anti-human type choline acetyltransferase (hpChAT) antibody...