A5034047684- Multiple Sclerosis Research Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Family Support in Illness
- Health, psychology, and well-being
- Family and Disability Support Research
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Congenital heart defects research
- Optimism, Hope, and Well-being
- Neurogenesis and neuroplasticity mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Attachment and Relationship Dynamics
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Intergenerational Family Dynamics and Caregiving
- Statistical Methods in Clinical Trials
- Neuroendocrine regulation and behavior
- Numerical Methods and Algorithms
- Cancer-related molecular mechanisms research
- Ergonomics and Human Factors
- Healthcare professionals’ stress and burnout
- Congenital limb and hand anomalies
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021-2025
King's College London
2019-2023
Ospedale Maggiore
2021-2023
Azienda Socio Sanitaria Territoriale Lariana
2021
Ospedale Papa Giovanni XXIII
2021
Sigmund Freud Institut
2021
ORCID
2021
Associazione Italiana Sclerosi Multipla
2019
Abstract Background Genetic syndromes resulting from chromosome 18 structural abnormalities constitute a broad spectrum of conditions characterized by significant clinical heterogeneity. Most studies in the literature focus on case reports and observations; present study aims to assess cognitive, communicative, behavioral, adaptive abilities different abnormalities. In addition, this work identify phenotype-genotype correlations comparing individuals with 18p deletion, 18q tetrasomy. Methods...
The experience of persons with multiple sclerosis (MS) and their caregivers is usually investigated in terms emotional distress health-related quality life , while well-being indicators remain largely underexplored. In addition, findings are often interpreted from the clinical perspective, neglecting socio-cultural aspects that may crucially contribute to individuals' functioning. At methodological level, most studies rely on scaled instruments, not allowing participants freely express needs...
Background: Specific cognitive rehabilitation in Multiple Sclerosis resulted to be effective compared no treatment, although the possible role of an aspecific psychological intervention and persistence over time its effects have not been clearly investigated till now. Objective: The aim SMICT RCT was compare efficacy a specific training with relapsing remitting patients. Methods: From sample 150 patients, same disability immunomodulatory therapy, submitted neuropsychological examination, 45...
Purpose: The aim of this study was to test the Common Sense Model Self-Regulation among persons with multiple sclerosis (MS), hypothesizing direct relations between illness beliefs and psychological adjustment, indirect through coping strategies social support.Materials methods: Questionnaires were administered cross-sectionally 680 participants (Mage =40.1; 64.4% women) recruited in eight MS units assess beliefs, strategies, support, adjustment indicators including life satisfaction,...
Health professionals caring for persons with multiple sclerosis (MS) are faced increasingly complex working conditions that can undermine their job satisfaction and the quality of healthcare services. The aim this study was to delve into health professionals' by assessing predictive role happiness meaning at work. Specifically, it hypothesized would moderate relationship between satisfaction.The hypothesis tested among 108 (53 physicians 55 nurses) in eight MS centers Italy. Participants...
Informal caregivers play a crucial role in supporting persons with multiple sclerosis (MS), neurodegenerative disease resulting progressive worsening of physical and cognitive functioning. While research extensively showed that caregiving workload can be perceived as burdensome, little attention was devoted to the relation connecting caregivers' well-being. Building on previous literature stress coping, aim this study test mediational coping between tasks A group 680 MS (M age = 46.45; 51.2%...
Cognitive rehabilitation in multiple sclerosis (MS) has been reported to induce neuropsychological improvements, but the persistence of these effects scarcely investigated over long follow ups. Here, results a multicenter randomized clinical trial are reported, which efficacy 15 week domain specific cognitive training was evaluated at 2 years up 41 patients. Included patients were randomly assigned either rehabilitation, or aspecific psychological intervention. Patients who still resulted be...
Background: Few studies have investigated the experiences of patients around conversion to secondary progressive multiple sclerosis (SPMS). ManTra is a mixed-method, co-production research project conducted in Italy and Germany develop an intervention for newly-diagnosed SPMS patients. In previous actions, we identified needs converting via literature review qualitative which involved key stakeholders. Aims: The online patient survey aimed assess, on larger independent sample...
the different lockdown phases due to COVID-19 may have negatively impacted pregnant women's mental health. Concerning antenatal stress, most studies focused more on effect of pandemic onset than impact following and restrictions.the present study aimed assess levels anxiety depression in a group Italian women during second phase possible risk factors.We recruited 156 through our Perinatal Psychology Outpatient Clinic. We divided sample into before (N = 88) face-to-face class (Covid-19 group)...
Abstract Background MSQOL-54 is a multidimensional, widely-used, health-related quality of life (HRQOL) instrument specific for multiple sclerosis (MS). Findings from the validation study suggested that two composite scores are correlated. Given this correlation, it could be assumed unique total score HRQOL may calculated, with advantage to provide key stakeholders single overall score. We aimed assess how well bifactor model account structure, in order verify whether can calculated. Methods...
The Multiple Sclerosis Quality of Life-54 (MSQOL-54) is one the most commonly-used MS-specific health-related quality life (HRQOL) measures. It a multidimensional, HRQOL inventory, which includes generic SF-36 core items, supplemented with 18 MS-targeted items. Availability an adaptive short version providing immediate item scoring may improve instrument usability and validity. However, multidimensional computerized testing (MCAT) has not been previously applied to MSQOL-54 We thus aimed...
Abstract Several changes in the behavioral phenotype arise with growth of children affected by Cornelia de Lange Syndrome (CdLS) and Rubinstein‐Taybi (RSTS). However, previous research relied on a cross‐sectional study design turning into age‐related comparisons different syndromic cohorts to explore age‐dependent changes. We aim outline variating pathways neuropsychiatric functioning across lifespan CdLS RSTS, through setting up longitudinal design. The sample included 14 patients 15 RSTS....
<title>Abstract</title> Background Genetic syndromes resulting from chromosome 18 structural abnormalities constitute a broad spectrum of conditions characterized by significant clinical heterogeneity. Most studies in the literature focus on case reports and observations; present study aims to assess cognitive, communicative, behavioral, adaptive abilities different abnormalities. In addition, this work identify phenotype-genotype correlations comparing individuals with 18p deletion, 18q...
Abstract Background : Cornelia de Lange Syndrome (CdLS) is a rare genetic disorder and its phenotype clinical expression widely variable. Despite the growing interest on genotype-phenotype correlations behaviour of syndromes, specific studies in CdLS cohorts evaluating between genotype neurodevelopmental characteristics, Behaviour communicative aspects are limited, most these descriptive there lack assessment protocols. Methods Neurodevelopmental Behavioural all patients (N = 38) was...
Within the framework of Salutogenic Model Health, this study aimed to investigate sense coherence among caregiving partners persons with multiple sclerosis (PwMS), and its relationship perceived social support illness beliefs conceived as generalized resistance resources in tension management.In cross-sectional study, 398 PwMS (Mage = 44.62; 34.9% women 65.1% men) filled questionnaires measuring (Sense Coherence Scale-13), from family, friends significant others (Multidimensional Scale...
Abstract Background Our study aims to understand whether depression, either in pregnancy or lifetime, affects cognitive biases (comprising the attentional focus and affective state) mentalizing features (ability children's internal mental states, thereby detecting comprehending their behavior intention), maternal speech during mother‐infant interaction first postnatal year. Methods We recruited 115 pregnant women (44 healthy, 46 with major depressive disorder [MDD] pregnancy, 25 a history of...