Skuld (skd) is a subunit of the Mediator complex complex. In heart, skd controls systemic obesity, involved in energy metabolism, and closely linked to cardiac function aging. However, it unclear whether effect on metabolism affects function. We found that cardiac-specific knockdown showed impaired function, metabolic impairment, premature Drosophila was subjected an exercise high-fat diet (HFD) intervention explore effects expression HFD Drosophila. Hand-Gal4>skd RNAi (KC) had Regular...

The major reason of human morbidity and mortality is obesity related diseases. Brown adipose tissue (BAT) associated with low total content a lower risk type 2 diabetes mellitus. Studies have shown that exercise cold expose may induce browning. In this study, we verified (1) whether and/or exposure can improve the expression level ucp4c, serca, ampkα, camkII, sirt1, octβ3r, hamlet; (2) if these interventions save cardiac dysfunction induced by high-fat diet (HFD) in Drosophila. w1118...

Abnormal heart rhythm is a common cardiac dysfunction in obese patients, and its pathogenesis related to systemic lipid accumulation. The cardiomyocyte-derived apoLpp (homologous gene Drosophila of the human apolipoprotein B) plays an important role whole-body metabolism under high-fat diet (HFD). Knockdown derived from cardiomyocytes can reduce HFD-induced weight gain abdominal In addition, exercise total amount circulation. However, relationship between regular exercise, abnormal unclear....

Abstract Alteration of HIF‐1α expression levels under hypoxic conditions affects the sequence its downstream target genes thereby producing different effects. In order to investigate whether effect compound exercise (HE) on alters cardiac pumping function, myocardial structure, and capacity, we developed a suitable model using Drosophila , organism, additionally investigated nocturnal sleep activity behavior. The results showed that at 6% oxygen concentration for five consecutive days,...

Obesity is a prevalent metabolic disorder associated with various diseases, including cardiovascular conditions. While exercise recognized as an effective approach for preventing and treating obesity, its underlying molecular mechanisms remain unclear. This study aimed to explore the impact of regular on high-fat-diet-induced obesity cardiac dysfunction in Drosophila, shedding light by identifying regulation dfoxo dsrebp signaling pathways. Our findings demonstrated that high-fat diet leads...

Bone metastasis caused the majority death of prostate cancer (PCa) but mechanism remains poorly understood.In this present study, we show that polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12) suppresses bone-specific PCa.GALNT12 proliferation, migration, invasion and cell division ability PCa cells by activating BMP pathway.Mechanistic investigations showed GALNT12 augments O-glycosylation BMPR1A then actives pathway.Activated signaling inhibits expression integrin αVβ3 to reduce...

Highly pathogenic avian influenza virus H5N1 can cause acute respiratory infections with an uncontrolled virus-induced cytokine storm in both poultry and humans. In view of the high mortality infection, development novel broad-spectrum prophylactic therapeutic agents against infection is urgently needed. present study, we attempted to explore whether combinational use a viral gene-targeted agent immunomodulator feasible as new strategy infection.Four antisense RNA oligonucleotides targeting...

Objective: The aim of this study was to compare the clinical efficacy and safety retroperitoneal laparoscopic open surgery for correction retrocaval ureter. Patients methods: Clinical data 14 patients with ureter were analyzed retrospectively. Among them, nine treated by surgical therapy five surgery. transpositioned a normal anatomic position followed intracorporeal uretero ureteric anastomosis. Results: Open successfully performed in cases. mean time 95.6±22.0 min, blood loss 108.6±34.5...

It is well-established that SPIB essential for the survival of mature B cells, playing a key role in diffuse large B-cell lymphoma, colorectal cancer, and lung cancer. However, no study has hitherto conducted systematic pan-cancer analysis on SPIB. Herein, we analyzed differential expression using The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases found was significantly upregulated most cancers. In addition, positively or negatively associated with prognosis...

Abstract Background Atherosclerotic plaque rupture increases the risk of ischemic heart disease and stroke commonly causes sudden death. High levels circulating or intraplaque interleukin 16 (IL-16) are clinically associated with a reduced incidence cardiovascular events. Here, we investigated effects IL-16 on phenotypic modification identified molecules involved in smooth muscle cells (SMCs). Methods We deleted ApoE-/- mice to generate IL16-/-ApoE-/- mice, double mutant was used for...

Apolipoprotein B plays an essential role in systemic lipid metabolism, and it is closely related to cardiovascular diseases. Exercise-training can regulate improve heart function, exercise capacity, but the molecular mechanisms involved are poorly understood. We used a Drosophila model demonstrate that exercise-training regulates expression of apoLpp (a homolog apolipoprotein B) cardiomyocytes, thereby resisting insufficiency low capacity caused by obesity. The carrier produced fat body . In...

<bold>Purpose:</bold> High-fat diets cause obesity and disease leading to excess appetite cardiovascular disease. At present, there is literature showing the improvement effect of exercise on related diseases. To explore more deeply mechanism action heart function in high-fat diets, we used fruit fly motility models reveal this aspect function. <bold>Methods:</bold> A total 300 wild-type W1118 virgin flies that matured within 12 hours were collected. They randomly divided into 100 animals...

Abstract Diastolic dysfunction is a major cardiac dysfunction, and an important predisposing factor age. Although exercise training often used for the prevention treatment of cardiovascular disease nowadays, little currently known about whether interventions associated with slowing aging are related to mtp ‐related pathways. In present study, UAS/Tub‐Gal4 system was knockdown whole‐body expression levels in Drosophila , which underwent 2 weeks endurance training. By conducting different...

Breast cancer is the most prevalent in female population and a significant cause of global deaths this group. Obesity increases woman’s risk developing breast has negative impact on prognosis. Metabolic alterations are an important part process migration; invasion proliferation, with lipids being major metabolic substrate for rapid progression, capable influencing crosstalk between tumor cells other microenvironment. Physical activity-induced irisin affects progression obesity-associated new...

Current evidence suggests that the heart plays an important role in regulating systemic lipid homeostasis, and high-fat diet (HFD)-induced obesity is a major cause of cardiovascular disease, although little known about specific mechanisms involved. Exercise training can reportedly improve abnormal metabolism cardiac dysfunction induced by diets; however, molecular are not yet understood. In present study, to explore relationship between exercise mtp HFD flies potential which affects flies,...

Although studies have shown that myomesin 2 (MYOM2) mutations can lead to hypertrophic cardiomyopathy (HCM), a common cardiovascular disease has serious impact on human life, the effect of MYOM2 cardiac function and lifespan in humans is unknown. In this study, dMnM (MYOM2 homologs) knockdown cardiomyocytes resulted diastolic defects (diastolic dysfunction arrhythmias) increased oxidative stress. Furthermore, indirect flight muscle (IFM) reduced climbing ability shortened lifespan. However,...

Cardiovascular disease (CVD) places a heavy burden on older patients and the global healthcare system. A large body of evidence suggests that exercise training is essential in preventing treating cardiovascular disease, but underlying mechanisms are not well understood. Here, we used Drosophila melanogaster animal model to study effects early-life (ELET) aging heart lifespan. We found flies age-induced arrhythmias conserved across different genetic backgrounds. The fat primary source...