A5008149966- CRISPR and Genetic Engineering
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Nuclear Receptors and Signaling
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Birth, Development, and Health
- Kruppel-like factors research
- Genomics, phytochemicals, and oxidative stress
- Cholesterol and Lipid Metabolism
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Sirtuins and Resveratrol in Medicine
- Calpain Protease Function and Regulation
- Advanced biosensing and bioanalysis techniques
- Aortic aneurysm repair treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Inflammatory mediators and NSAID effects
- Xenotransplantation and immune response
- Chemokine receptors and signaling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Gestational Diabetes Research and Management
Guiyang Medical University
2013-2024
First Affiliated Hospital of Shihezi University Medical College
2015
Shanghai Jiao Tong University
2008-2013
Shanghai Children's Hospital
2013
In-Q-Tel
2013
Shanghai Institute of Hematology
2008
Oxidized high-density lipoprotein (oxHDL) reduces the ability of cells to mediate reverse cholesterol transport and also shows atherogenic properties. Palmitoylation cluster differentiation 36 (CD36), an important receptor mediating uptake, is required for fatty acid endocytosis. However, relationship between oxHDL CD36 has not been described in mechanistic detail. Here, we demonstrate using acyl-biotin exchange analysis that activates by increasing palmitoylation, which promotes efficient...
Macrophage inflammation and oxidative stress promote atherosclerosis progression. Naringenin is a naturally occurring flavonoid with antiatherosclerotic properties. Here, we elucidated the effects of naringenin on monocyte/macrophage endothelial infiltration vascular inflammation. We found inhibited oxidized low-density lipoprotein (oxLDL)-induced pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α toward an M2 macrophage phenotype oxLDL-induced TLR4 (Toll-like receptor 4) membrane...
Scope Maternal consumption of a high‐fat diet (HFD) during pregnancy increases the risk behavioral problems. Folate plays an important role in neuroplasticity and preservation neuronal integrity. This study aims at determining influence diets supplemented with folate on offspring behavior, mechanisms involved. Methods results Female mice were fed control diet, HFD, folate, or HFD for 5 weeks before mating. Open field task elevated plus maze are used to evaluate behaviors. Results showed that...
Alpinetin is a plant flavonoid isolated from Alpinia katsumadai Hayata with antioxidant and anti-inflammatory properties. Monocyte infiltration into the intima promotes atherosclerotic development causes plaque instability at later stage, which profoundly influenced by various oxidants. In this study, we investigated whether alpinetin restores redox state to inhibit monocyte ameliorates atherosclerosis. ApoE-deficient (ApoE−/−) mice were fed high-fat diet treated alpinetin. We found that...
We determined the alleles of ten single nucleotide poly-morphisms (SNPs) in APOA5/A4/C3/A1 gene cluster and APOB Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, explored correlation between these SNPs dyslipidemia through a case-control study design with 250 pa-tients normal controls. All except for APOA5 rs2072560 conformed to Hardy-Weinberg equilibrium (all P > 0.05). rs651821, APOA4 rs5104, APOC3 rs734104, rs5128 geno-type allele frequencies were significantly...
ϕC31 integrase, a site‐specific recombinase, can effectively mediate foreign genes bearing an attB sequence integrated into pseudo attP sites. We have previously identified two sites, BpsF1 and BpsM1 from the bovine genome. In this study, new BF4 BF10, were discovered using half‐nested inverse PCR cow fibroblasts. The genomic locations of these sites by direct sequencing BLAST search, it was confirmed that they reside at positions 4q31 10q35 fluorescence in situ hybridization analysis....
Abstract The Gal4/upstream activating sequences (UAS) system offers great advantages in target gene expression by separating the responder line and diverse tissue‐specific expressed Gal4 driver lines Drosophila . bipartite is commonly used gain‐of‐function analysis, combining with RNA interference technology, it can also be applied loss‐of‐function analysis. However, off‐target effect caused this strategy has not been well solved so far. Furthermore, only partially knockdown a specific...
Abstract Background Atherosclerotic plaque rupture increases the risk of ischemic heart disease and stroke commonly causes sudden death. High levels circulating or intraplaque interleukin 16 (IL-16) are clinically associated with a reduced incidence cardiovascular events. Here, we investigated effects IL-16 on phenotypic modification identified molecules involved in smooth muscle cells (SMCs). Methods We deleted ApoE-/- mice to generate IL16-/-ApoE-/- mice, double mutant was used for...