A5055346665- Pain Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Immune cells in cancer
- Cancer Research and Treatments
- Chemokine receptors and signaling
- Effects of Radiation Exposure
- Cancer Cells and Metastasis
- Gastrointestinal motility and disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Pharmacological Receptor Mechanisms and Effects
- Botulinum Toxin and Related Neurological Disorders
- Pharmacology and Obesity Treatment
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- Biochemical Analysis and Sensing Techniques
National Health Research Institutes
2019-2024
National Defense Medical Center
2011-2020
Taipei Medical University
2011-2014
National Defense Medical College
2011
Rationale: Multiple copies in T-cell malignancy 1 (MCT-1) is a prognostic biomarker for aggressive breast cancers.Overexpressed MCT-1 stimulates the IL-6/IL-6R/gp130/STAT3 axis, which promotes epithelial-to-mesenchymal transition and cancer stemness.Because stemness largely contributes to tumor metastasis recurrence, we aimed identify whether blockade of IL-6R can render these effects understand underlying mechanisms that govern process.Methods: We assessed primary invasion, postsurgical...
Seaweed polysaccharides have been recommended as anticancer supplements and for boosting human health; however, their benefits in the treatment of triple-negative breast cancers (TNBCs) improving immune surveillance remain unclear. Olaparib is a first-in-class poly (ADP-ribose) polymerase inhibitor. Oligo-Fucoidan, low-molecular-weight sulfated polysaccharide purified from brown seaweed (Laminaria japonica), exhibits significant bioactivities that may aid disease management.Macrophage...
Opioid antagonists, such as naloxone and naltrexone, exhibit agonistic properties at the mutated μ receptor, MOR-S196ACSTA. In our previous study, systemic (10 mg·kg(-1) , s.c.) elicited antinociceptive effect without induction of tolerance, dependence or rewarding in mice 2 weeks after intrathecal administration double-stranded adeno-associated virus-MOR-S196ACSTA-eGFP. Here, we have investigated if this paradigm would be effective a mouse model neuropathic pain.Spinal nerves were ligated...
In our previous study, we first demonstrated a significant effect of dextromethorphan (DM) on morphine-seeking behavior in morphine-dependent rats, when DM was given during morphine withdrawal. Using the same conditioned place preference (CPP) paradigm modified for measuring drug-seeking-related behavior, further investigated possible methamphetamine (MA)-seeking MA-dependent rats. Our data showed that could also effectively suppress drug-seeking MA, administered MA This suggests may possess...
Neuropathic pain is a serious clinical problem that difficult to treat. Purinoceptors (P2Rs) transduce perception from the peripheral central nervous system and play an important role in transmission of neuropathic signals. We previously found crude extracts Hericium erinaceus mycelium (HE-CE) inhibited P2R-mediated signaling cells reduced heat-induced mice. The present study explored effects HE-CE on pain. used adenosine triphosphate (ATP) as P2R agonist generate Ca2+ neuronal damage cell...
Abstract Background Multiple copies in T-cell malignancy 1 (MCT-1) is a prognostic biomarker for aggressive breast cancers. Overexpressed MCT-1 stimulates the IL-6/IL-6R/gp130/STAT3 axis, which promotes epithelial-to-mesenchymal transition, cancer stemness and tumor progression. Methods We studied mechanism underlying triple-negative (TNBC) immunity aggressiveness assessed primary invasion, postsurgical local recurrence distant metastasis orthotopic syngeneic mice given indicated...
Abstract Multiple Copies in T-cell Malignancy-1 (MCT-1 or MCTS1) is a prognostic biomarker for aggressive breast cancers. Overexpressed MCT-1 stimulates the IL-6/IL-6R/gp130/STAT3 axis, promoting epithelial-to-mesenchymal transition, cancer cell stemness and tumor progression. To study mechanism underlying TNBC immunity aggressiveness, lines with different expression levels were evaluated. Primary invasion postsurgical local recurrence distant metastasis assessed orthotopic syngeneic mice...