A5100428114- Pain Mechanisms and Treatments
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Fungal Biology and Applications
- Botulinum Toxin and Related Neurological Disorders
- Pharmacological Effects of Natural Compounds
- Sleep and Wakefulness Research
- Ginkgo biloba and Cashew Applications
- Medicinal Plants and Bioactive Compounds
- Pharmacological Receptor Mechanisms and Effects
- Respiratory viral infections research
- Gut microbiota and health
- Advancements in Transdermal Drug Delivery
- Neural dynamics and brain function
- Phytoestrogen effects and research
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Dermatological and COVID-19 studies
- Neurobiology and Insect Physiology Research
- Neurogenesis and neuroplasticity mechanisms
- Osteoarthritis Treatment and Mechanisms
- Sesquiterpenes and Asteraceae Studies
- Stress Responses and Cortisol
- Body Image and Dysmorphia Studies
Grape King (Taiwan)
2020-2024
Nantong University
2022
China Medical University
2011-2022
Affiliated Hospital of Nantong University
2022
Linkou Chang Gung Memorial Hospital
2017
Bali Psychiatric Center
2014
Chung Yuan Christian University
2014
National Taiwan University Hospital
2014
Chi Mei Medical Center
2006-2014
National Cheng Kung University
2014
To investigate the efficacy and safety of three
ABSTRACT Epidemiological studies have shown that early life adverse events long‐term effects on the susceptibility to subsequent stress exposure in adolescence, but precise mechanism is unclear. In present study, mice postnatal day 21–28 were randomly assigned either a group or isolated cages for 8 weeks. The socially (SI) exhibited higher level of spontaneous locomotor activity, longer duration immobility forced swimming test (FST), significantly less prepulse inhibition (PPI) and an...
Objective The aim of this study was to investigate the clinical curative effect hyperbaric oxygen (HBO) treatment and its mechanism in improving dysfunction following traumatic brain injury (TBI). Methods Patients were enrolled into control HBO groups. Glasgow coma scale (GCS) recovery scale-revised (CRS-R) scores used measure consciousness; Rancho Los Amigos (RLAS-R) score assess cognitive impairment; Stockholm computed tomography (CT) score, quantitative electroencephalography (QEEG),...
Memantine blocks N-methyl-D-aspartate receptors and the Na(+) current, one principal mechanism of local anesthesia. Until now, no study mentioned that memantine had a anesthetic effect, therefore we investigated effect memantine.After blockade cutaneous trunci muscle reflex with subcutaneous injections, evaluated analgesic memantine, lidocaine, dizocilpine (MK-801) in rats. The dose-dependent response on analgesia was compared lidocaine MK-801 duration action for each drug an equipotent...
Hericium erinaceus mycelium extract (HEM), containing erinacine A (HeA) and S (HeS), has shown promise in promoting the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs), crucial for myelin production central nervous system (CNS). The main aim this study was to characterize protective effects HEM its components on OLs demyelinating rodents by exposure cuprizone (CPZ), a copper chelating agent commonly used induce demyelination corpus callosum brain....
Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus a large edible mushroom with several known medicinal functions. However, therapeutic effects of H. in OA are unknown. In this study, data from Sprague-Dawley rats knee induced by anterior cruciate ligament transection (ACLT) indicated mycelium improves ACLT-induced weight-bearing asymmetry minimizes pain. increases articular cartilage degradation bone erosion were...
An analgesic with a prolonged duration may be desirable in patients long-lasting pain. In this study, we evaluated the antinociceptive effects and durations of action three novel depots buprenorphine esters propionate, enanthate, decanoate given by IM injection, rats. The pharmacokinetic profiles blood after injection these were also evaluated. Antinociception was using plantar test. Buprenorphine concentrations assayed high-performance liquid chromatography. We found that traditional form...
Metabolite identification, in the early stage, for compound discovery is necessary to assess knowledge pharmaceutical improvement of drug safety and efficacy. Even if has been released into market, identification continuous evaluation metabolites are required avoid risk post-marketing withdrawal. Hericium erinaceus (HE), a medicinal mushroom, broadly documented nutraceutical benefits, including anti-oxidant, anti-tumor, anti-aging, hypolipidemic, gastric mucosal protection effects. Recently,...
Contralateral hyperalgesia, occurring after unilateral injury, is usually explained by central sensitization in spinal cord and brain. We previously reported that injection of endothelin-1 (ET-1) into one rat hindpaw induces prolonged mechanical chemical the contralateral hindpaw. Here, we examined role efferent activity this process.ET-1 (2 nmol, 10 μL) was injected subcutaneously plantar surface right (ipsilateral) (ILP), thermal response latency threshold for nocifensive withdrawal were...
Neuropathic pain is a serious clinical problem that difficult to treat. Purinoceptors (P2Rs) transduce perception from the peripheral central nervous system and play an important role in transmission of neuropathic signals. We previously found crude extracts Hericium erinaceus mycelium (HE-CE) inhibited P2R-mediated signaling cells reduced heat-induced mice. The present study explored effects HE-CE on pain. used adenosine triphosphate (ATP) as P2R agonist generate Ca2+ neuronal damage cell...
This present study was undertaken to determine whether beta-blockers produce the cutaneous analgesic effect, comparing them with long-acting local anesthetic bupivacaine.Using a rat model of infiltrative analgesia, effect 5 (oxprenolol, carteolol, butaxamine, metoprolol, and acebutolol) bupivacaine compared eventually combined epinephrine.Among beta-blockers, oxprenolol exhibited most potent longest duration analgesia. In dose-response studies, rank order efficacy (ED50 [50% effective dose])...
Doxepin, a tricyclic antidepressant, was recently found to be effective in the treatment of various acute and chronic painful conditions. However, mechanism its actions not clear, especially when involving spine. The aim our study evaluate spinal anesthetic effect doxepin. Two commonly used traditional local anesthetics, bupivacaine lidocaine, were as controls. potencies durations drugs' action evaluated male Sprague-Dawley rats. We that intrathecally administered doxepin, like produced...
Dextrorphan could be a local anesthetic, while adding epinephrine to the anesthetics prolonged their duration of action. Here we investigated whether as adjuvant prolong anesthetic effect dextrorphan. The cutaneous analgesic addition (5 μg/mL) dextrorphan was assessed in rats following blockade trunci muscle reflex through subcutaneous injection drugs. We showed that elicited dose-dependent analgesia. Co-administration g/mL) with at 50% effective dose (ED50) or ED95 had longer than (ED50...
WHAT is relapsing fever? It an acute infectious disease characterized by fever of sudden onset which, after several days rapid remission may relapse at intervals from one to more for indefinite number times but rarely than three (third rare) depending on the resistance individual. also might be simply defined as a septicemia caused spirochetes. The spirochete now known Treponema recurrentis. very slender quite long. A peculiar feature its tendency disappear suddenly blood just before fall...