A5051321436- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- Congenital Ear and Nasal Anomalies
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- IL-33, ST2, and ILC Pathways
- Infectious Diseases and Tuberculosis
- Eosinophilic Esophagitis
- Adenosine and Purinergic Signaling
- Complement system in diseases
- Chronic Lymphocytic Leukemia Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Otitis Media and Relapsing Polychondritis
- Signaling Pathways in Disease
- Cystic Fibrosis Research Advances
- Diabetes and associated disorders
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Biochemical and Structural Characterization
- Vascular Malformations and Hemangiomas
Marmara University
2023-2025
Jeffrey Modell Foundation
2025
Sağlık Bilimleri Üniversitesi
2021
Objective: Prolidase deficiency is a metabolic and immunological disorder that inherited in an autosomal recessive manner. In prolidase deficiency, broad spectrum of differences observed patients, ranging from asymptomatic to multisystem involvement. There scarce information the literature on atypical features immunophenotypes this disease. Aim study present 4 new cases provide rare disease raise awareness. Materials Methods: This included female patients with deficiency. Their demographic,...
Immunoglobulin G replacement therapy (IgRT), intravenous (IV) and subcutaneous (SC) routes, is pivotal in treatment of primary immunodeficiencies (PID). In recent years, facilitated immunoglobulin (fSCIG), a combination rHuPH20 10% IgG has emerged as delivery method to combine advantages both IV SC.
Loss of function mutations in Diaphanous related formin 1 (DIAPH1) are associated with seizures, cortical blindness, and microcephaly syndrome (SCBMS) recently linked to combined immunodeficiency. However, the extent defects T innate lymphoid cells (ILCs) remain unexplored. Herein, we characterized primary T, natural killer (NK) helper ILCs six patients carrying two novel loss mutation DIAPH1 Jurkat after knockdown. Mutations were identified by whole exome sequencing. T-cell...
Abstract Infants with congenital heart disease (CHD) often undergo thymectomy during corrective cardiac surgery (CCS). The long‐term immunological effects remain controversial, concerns regarding increased susceptibility to infections, allergies, autoimmunity due compromised immune tolerance mechanisms. This study aims elucidate the of early thymectomy. We enrolled 22 patients who underwent in infancy and were followed up Pediatric Allergy Immunology Clinic at Marmara University. performed...
<title>Abstract</title> <bold>Purpose:</bold> Immunodysregulation, Polyendocrinopathy, Enteropathy, and X-linked syndrome (IPEX), caused by <italic>FOXP3</italic> mutations, is a rare autoimmune disorder with diverse clinical features, including early-onset diabetes, eczema, enteropathy. Atypical cases show milder symptoms unique signs, requiring different treatments. Therefore, there are ambiguities in the accurate diagnosis management of IPEX. We sought to present clinical, genetic,...
Abstract Objective This study aimed to investigate interferon-gamma-inducible protein-10 (IP-10) values in serum and urine pediatric patients the diagnosis of active tuberculosis (TB) or latent TB infection (LTBI). It also whether it can be used as a biomarker distinguish between LTBI. Methods Our comprised (25 patients), LTBI “infected” group (50 patients) formed by combining two groups. As control group, 37 healthy children were included study. skin test, plasma IP-10, IP-10 measurements...