The crude extracts (dichloromethanic and ethanolic) some compounds (8 flavonoids 5 steroids) isolated from Chromolaena squalida (leaves stems) hirsuta flowers) have been evaluated against 22 strains of microorganisms including bacteria (Gram-positive Gram-negative) yeasts. All extracts, steroids shown actives, mainly Gram-positive bacteria.

Eclipta prostrata (L.) L. (Asteraceae) has been used in Brazilian traditional medicine to treat asthma and other respiratory illnesses.To investigate the effects of different doses a standardized extract E. using murine model allergen induced asthma.Balb/c mice were sensitized twice with ovalbumin (OVA) administered intraperitoneally challenged over four alternate days nasal instillations OVA solution. The methanol was 100, 250 500mgkg-1 concomitantly instillation seven consecutive days....

Uncaria tomentosa (Willd. Ex Schult) DC is used by indigenous tribes in the Amazonian region of Central and South America to treat inflammation, allergies asthma. The therapeutic properties U. have been attributed presence tetracyclic pentacyclic oxindole alkaloids phenolic acids.To characterize aqueous bark extracts (ABE) leaf (ALE) compare their anti-inflammatory effects.Constituents were identified ultra performance liquid chromatography-mass spectrometry. Anti-inflammatory activities...

Uncaria tomentosa (Rubiaceae) has a recognized therapeutic potential against various diseases associated with oxidative stress. The aim of this research was to evaluate the antioxidant an aqueous leaf extract (ALE) from U. tomentosa, and its major alkaloids mitraphylline isomitraphylline. activity ALE investigated in vitro using standard assays (DPPH, ABTS FRAP), while vivo mode action were studied Caenorhabditis elegans as model organism. purified did not exhibit effects vivo. reduced...

The aim of this work was to evaluate the efficacy and safety Lippia origanoides essential oil as a preservative in industrial products.The composition, antimicrobial activity, mutagenic toxic potential L. were determined. Then, effect food, cosmetics pharmaceutical products evaluated. consisted mainly oxygenated monoterpenes (38·13%); 26·28% corresponded compound carvacrol. At concentrations ranging from 0·312 1·25 μl ml-1 association with polysorbate 80, inhibited growth all tested...

Infections of sheep with gastrointestinal parasites, especially Haemonchus contortus, have caused serious losses in livestock production, particularly after the emergence resistance to conventional anthelmintics. The search for new anthelmintic agents, those botanical origin, has grown substantially due perspective less contamination meat and milk, as well other advantages related their cost accessibility developed countries. aim this study was evaluate vitro activity essential oils plant...

Abstract Phytochemical study of Chromolaena hirsuta (Hook. & Arn.) R. King H. Robinson crude extract (collected in Furnas, MG‐Brasil) produced fifteen flavonoids, two triterpenes and five steroids. IR, UV, 1 H 13 C NMR spectroscopy GC analysis were used for the identification these compounds. The dichloromethanic ethanolic extracts (flowers leaves) six flavonoids isolated from this specie have been assayed antiprotozoal activity against tripomastigote forms Trypanosoma cruzi promastigote...

Type‐2 diabetes mellitus (DM) is a highly prevalent disease with significant morbidity and mortality around the world. However, there no universally effective treatment, because response to different treatment regimens can vary widely among patients. In this study, we aimed investigate whether use of powdered dried leaves Eugenia punicifolia (Kunth) DC. (Myrtaceae) as an adjuvant patients type‐2 DM. Fifteen were enrolled in pilot, non‐controlled received E . for 3 months. After observed...

The genus Lippia comprises 150 species, most of which have interesting medicinal properties. sidoides (syn. L. origanoides) exhibits strong antimicrobial activity and is included in the phytotherapy program implemented by Brazilian Ministry Health. Since species are morphologically very similar, conventional taxonomic methods sometimes insufficient for unambiguous identification plant material that required production certified phytomedicines. Therefore, genetic chemical analysis with...

Tabernaemontana catharinensis root bark ethanol extract, EB2 fraction and the MMV alkaloid (12-methoxy-4-methylvoachalotine) were evaluated for their antimicrobial activities. T. extract was effective against both strains of dermatophyte Trichophyton rubrum at concentrations 2.5 mg/mL (wild strain) 1.25 (mutant strain), while showed a strong antifungal activity wild mutant with MIC values <0.02 0.16 mg/mL, respectively. The antibacterial ATCC S. aureus, epidermidis, E. coli P. aeruginosa...

Abstract Objectives The purpose of the present work was to characterize pharmacological profile different L. alba chemotypes and correlate obtained data presence chemical constituents detected by phytochemical analysis. Methods Essential oils from each chemotype (LP1—LP7) were characterized gas chromatography–mass spectrometry (GC-MS) extracted non-volatile compounds analysed HPLC GC-MS. anticonvulsant actions studied in pentylenetetrazole-induced clonic seizures mice their effect on motor...

Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting genital tract. Crude extract, fractions and pure compound isolated from roots this species were investigated to validate their antimicrobial activity against Escherichia coli Staphylococcus aureus. The ent-kaur-16-en-18-oic acid was as major component (0.7% crude extract), its MIC value determined S. aureus (ATCC 6538) 250 μg/mL. This first phytochemical work on...

GC analysis of the dichloromethane extracts obtained from cultivated specimens Mikania glomerata Sprengel possibilited to verify that cuttings technique led production kaurenoic acid and coumarin while same results have not been observed by propagation process using in vitro techniques.

Costus spiralis , a plant used in traditional Brazilian medicine for the treatment of complications diabetes, was investigated. Assay hexane, ethyl acetate, methanol, and aqueous fractions obtained by partition crude methanol extract dried leaves C. revealed that AGI activity confined to acetate fraction. Purification this fraction yielded schaftoside isoschaftoside. The activities two flavones were lower than, but comparable with, anti‐diabetic drug acarbose. In contrast, IC 50 value 1.95‐,...

In this work, twelve flavonoids were detected in glandular trichomes of two species Chromolaena through the microsampling technique and HPLC-UV-DAD analysis. This is first time that accumulation genus reported. Based on results, we suggest can be an useful tool search new compounds with medicinal properties as well chemotaxonomic studies Eupatorieae.

Increased neutrophil activation significantly contributes to the tissue damage in inflammatory illnesses; this phenomenon has motivated search for new compounds modulate their effector functions. Coumarins are natural products that widely consumed human diet. We have evaluated antioxidant and immunomodulator potential of five 4-methylcoumarin derivatives. found derivatives inhibited generation reactive oxygen species by neutrophils triggered serum-opsonized zymosan or...

Abstract Excessive generation of reactive oxygen species (ROS) by polymorphonuclear leukocytes (PMNL) is involved in the pathology many inflammatory diseases. Compounds isolated from natural sources with antioxidant activity can be helpful to inhibit and/or modulate oxidative damage associated PMNL‐derived ROS. The present study investigated relationship between chemical structure five methoxylated flavonoids, Chromolaena hirsuta and squalida , their inhibitory on ROS opsonized...

Abstract: Aiming at contributing with the search for neuroactive substances from natural sources, we report first time antinociceptive and anticonvulsant effects of some Lychnophora species. We verify protective polar extracts (600 mg/kg, intraperitoneally), methanolic fractions L. staavioides rupestris (100 intraperitoneally) in pentylenetetrazole‐induced seizures on mice. Previously, a screening was accomplished, evaluating central activity ( hot plate test), different , diamantinana . It...

Palicourea rigida HBK, known as “douradinha”, “bate-caixa” and “douradao” is endemic to Brazilian Cerrado belongs the Rubiaceae family. The aqueous hydroalcoholic extracts of P. rigida have been traditionally used in treatment of urinary tract disorders. aim this work was study chemical diversity eight populations rigidanative regions states Sao Paulo, Goias Minas Gerais. loganin quantification performed by (High-performance liquid chromatography) HPLC correlation among iridoid contents...

Anemopaegma arvense (Vell) Stellf. ex de Souza belongs to the family Bignoniaceae, and is popularly known as catuaba. To evaluate cytotoxic antimicrobial activity of A. arvense, fraction F3 flavonoids 1 (quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside) (rutin) flavonoid 2 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside) were isolated from leaves this plant. Fraction exhibited no antibacterial activity. Furthermore, 3 or was observed against tumor cells tested. However,...