A5083200090- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Diet and metabolism studies
- Thyroid Disorders and Treatments
- Rabies epidemiology and control
- Hormonal and reproductive studies
- Viral Infections and Vectors
- Adrenal and Paraganglionic Tumors
- Adipose Tissue and Metabolism
- Ophthalmology and Eye Disorders
- Virology and Viral Diseases
- Bat Biology and Ecology Studies
- Venous Thromboembolism Diagnosis and Management
- Mitochondrial Function and Pathology
- Adrenal Hormones and Disorders
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- Effects and risks of endocrine disrupting chemicals
- Lipid metabolism and disorders
- Glioma Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- Pharmacological Effects and Toxicity Studies
Charité - Universitätsmedizin Berlin
2010-2024
Robert Koch Institute
2020-2024
Brandenburg University of Applied Sciences
2022
University Hospital of Zurich
2021
University of Zurich
2021
Federal Institute for Risk Assessment
2017-2019
Radboud University Nijmegen
2018
Radboud University Medical Center
2018
Utrecht University
1976-2015
German Institute of Human Nutrition
2015
OBJECTIVE The incidence of the metabolic syndrome and type 2 diabetes mellitus (T2DM) is rising worldwide. Liver-derived fibroblast growth factor (FGF)-21 affects glucose lipid metabolism. aim this study was to analyze predictive value FGF-21 on T2DM syndrome. RESEARCH DESIGN AND METHODS Metabolic Syndrome Berlin Potsdam (MeSyBePo) recall includes 440 individuals. Glucose metabolism analyzed using an oral tolerance test, including insulin measurements. measured enzyme-linked immunosorbent...
Specific receptor binding of estradiol (E-2) and dihydrotestosterone (DHT) was studied in human myometrial tissue mammary cancer tissue. The inhibition for E-2 DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) 5-androstene-3beta, 17beta-diol (Adiol) tested with the use dextran-coated charcoal separation bound free respectively, DHT. percentage calculated reference to obtained nafoxidine a molar concentration ratio...
Urinary production rates of dehydroepiandrosterone (D) and sulfate (DS) by isotope dilution, the blood rate androstenedione (A) continuous infusion technique have each been measured in 8 normal postmenopausal women. Both measurements were done a group 6 breast cancer patients. The patients at time primary operation least yr postmenopausal; study they 3 after operation. All them good health free demonstrable recurrence tumor. contribution D DS to urinary estrogens conversion A estrone...
The Animal Study Registry (ASR; www.animalstudyregistry.org) was launched in January 2019 for preregistration of animal studies order to increase transparency and reproducibility bioscience research promote welfare. registry is free charge designed exploratory confirmatory within applied science as well basic preclinical research. registration form helps scientists plan their study thoroughly by asking detailed questions concerning design, methods, statistics. With registration, the...
A key challenge of mixture toxicity testing is that a multitude substances with even more combinations need to be tested in broad dose range. Consequently rodent bioassays, the current gold standard testing, hardly feasible. High-throughput compatible cell culture systems, however, suffer from limitations respect toxicokinetics, tissue interactions, and compensatory mechanisms. Therefore, simple organisms like nematode Caenorhabditis elegans, combining relevant advantages complex vivo fast...
The reliable detection of SARS-CoV-2 has become one the most important contributions to COVID-19 crisis management. With publication first sequences SARS-CoV-2, several diagnostic PCR assays have been developed and published. In addition in-house market was flooded with numerous commercially available ready-to-use kits, both approaches showing alarming shortages in reagent supply.
Summary Objective Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. aim this study was to analyse whether predicts T2DM. Design Blood samples 440 participants Metabolic‐Syndrome Berlin‐Potsdam (MesyBepo) follow‐up without at baseline were available for measurement. Mean 5·3 years. Glucose metabolism analysed using oral glucose tolerance test including insulin...
Small carp were used for the determination of exophthalmos-producing substance (EPS) in serum. They are easy to maintain and show no seasonal variations response EPS. Readily reproducible results wero obtained. The regression lines a pituitary extract pooled serum exophthalmic patients showed same slope. Sera 9 normal persons caused increase intercorneal distance fish. sera 38 withvarious thyroid disturbances assayed. In patients, who at time thyrotoxic, EPS values tended be higher than...
The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults.To assess whether at baseline any yearly follow-up time point, with or without anemia, was associated changes from in high-sensitivity C-reactive protein (hs-CRP) interleukin-6 (IL-6) over 3 years.This is a post-hoc observational analysis of DO-HEALTH, double-blind, randomized controlled trial including 2157 European community-dwelling...
Reducing the expression of Indy (Acronym for 'I'm Not Dead, Yet') gene in lower organisms promotes longevity and leads to a phenotype that resembles various aspects caloric restriction. In C. elegans, available data on life span extension is controversial. Therefore, aim this study was determine role elegans INDY homolog CeNAC2 regulation delineate possible molecular mechanisms. siRNA against Indy/CeNAC2 used reduce Indy/CeNAC2. Mean assessed four independent experiments, as well whole body...
Betatrophin has been identified as a marker linking liver with beta cell function and lipid metabolism in murine models. Until now, the regulation of circulating betatrophin humans is not entirely clear. We here analyzed relation levels to phenotypes metabolic syndrome speculated that renal might influence explain age-dependent changes betatrophin.We blood samples from 535 individuals participating Metabolic Syndrome Berlin Potsdam study.In crude analysis we found positive correlation...
Δ5-Androstene-3β17β-diol (Adiol), in a dosage of 1000 μg/24 h injected ip into immature female Wistar rats (21-23 days old), induced 72 after the injection same elevations uterine weight, cytosol protein, nuclear DNA, estrogen and progesterone receptors, receptor levels as did 17β-estradiol (E2) 2.5 h. Adiol appeared to translocate induce synthesis receptors manner almost identical that E2. Studies on metabolism tritiated ruled out possibility estrogenic effects might be mediated by...
SUMMARY We designed a systematic study of patients with Cushing's disease to compare the results acute experiments cyproheptadine, sodium valproate and bromocriptine chronic treatment valproate. In 13 plasma Cortisol response single doses 2.5 mg bromocriptine, 6 cyproheptadine 300 was assessed over 4.8 h. All were then treated 200 three times day for period 3 months. Subjects classified as responders when there reduction in by at least 50% below basal level two consecutive samples during one...
SUMMARY The production of testosterone (Te) and androstenedione (A) has been studied in twenty‐three patients with chronic renal failure. Four the were being prepared for haemodialysis (HD) treatment — non‐HD nineteen on HD treatment, five whom had nephrectomized bilaterally. Data are presented plasma Te A levels, response to HCG changes after HD. Metabolic Clearance Rate (MCR), blood rate mutual interconversion both steroids determined together sex hormone binding globulin capacity. In all...
We developed a new probabilistic model to assess the impact of recommendations rectifying reproducibility crisis (by publishing both positive and 'negative' results increasing statistical power) on competing objectives, such as discovering causal relationships, avoiding false results, reducing resource consumption. In contrast recent publications our quantifies each single suggestion not only for an individual study but especially their relation consequences overall scientific process. can...