A5007576743- Enzyme Structure and Function
- Plant Pathogenic Bacteria Studies
- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Enzyme Production and Characterization
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Biofuel production and bioconversion
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Plant nutrient uptake and metabolism
- Glycosylation and Glycoproteins Research
- Oil Palm Production and Sustainability
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Genetics and Neurodevelopmental Disorders
- Inflammasome and immune disorders
- Porphyrin Metabolism and Disorders
- Receptor Mechanisms and Signaling
- Plant pathogens and resistance mechanisms
- Diet, Metabolism, and Disease
- Studies on Chitinases and Chitosanases
- Signaling Pathways in Disease
Ludwig-Maximilians-Universität München
2018-2024
European Molecular Biology Laboratory
2024
Free University of Bozen-Bolzano
2017
University of Auckland
2012-2014
Abstract The cyclic dinucleotide second messenger c-di-AMP is a major player in regulation of potassium homeostasis and osmolyte transport variety bacteria. Along with various direct interactions proteins such as channels, the also specifically binds to transcription factors, thereby altering processes cell on transcriptional level. We here describe structural biochemical characterization BusR from human pathogen Streptococcus agalactiae. member yet structurally uncharacterized subfamily...
How chromatin enzymes work in condensed and how they maintain diffusional mobility inside remains unexplored. We investigated these challenges using the
AmyR is a stress and virulence associated protein from the plant pathogenic Enterobacteriaceae species Erwinia amylovora, functionally conserved ortholog of YbjN Escherichia coli. The crystal structure E. amylovora reveals class I type III secretion chaperone-like fold, despite lack sequence similarity between these two classes lacking any evidence secretion-associated role. results indicate that AmyR, proteins in general, function through protein-protein interactions without enzymatic...
Students measure the changes in cyclic AMP, a second messenger molecule, with light-based assay.
The central component AcrB of the Escherichia coli drug efflux complex AcrA–AcrB–TolC has been extensively investigated by X‐ray crystallography detergent–protein 3‐D crystals. In these crystals, packs as trimers – functional unit. We visualized AcrB–AcrB interaction in its native environment examining E. lipid reconstituted 2‐D which were overwhelmingly formed asymmetric stabilized strongly‐interacting monomers from adjacent trimers. Most interestingly, we observed lattices an arrangement...