A5101605214- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Laser Applications in Dentistry and Medicine
- Virus-based gene therapy research
- Circular RNAs in diseases
- Agriculture, Soil, Plant Science
- RNA regulation and disease
- Brucella: diagnosis, epidemiology, treatment
- Probiotics and Fermented Foods
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Tea Polyphenols and Effects
- TGF-β signaling in diseases
- Sirtuins and Resveratrol in Medicine
- Trace Elements in Health
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Medical Research and Treatments
- Healthcare and Venom Research
- Invertebrate Immune Response Mechanisms
- Autophagy in Disease and Therapy
Shaanxi Normal University
2024-2025
Jiangsu Nhwa Pharmaceutical (China)
2025
Xi'an Medical University
2025
Hunan Cancer Hospital
2016-2024
Central South University
2012-2024
Nankai University
2022-2024
Guangdong Academy of Sciences
2024
Guangdong Pharmaceutical University
2024
Shaanxi University of Science and Technology
2024
Ningxia Medical University
2017-2023
Ferroptosis is a form of iron-dependent programmed cell death, which distinct from apoptosis, necrosis, and autophagy. Mitochondria play critical role in initiating amplifying ferroptosis cancer cells. Voltage-Dependent Anion Channel 1 (VDAC1) embedded the mitochondrial outer membrane, exerts roles regulation ferroptosis. However, mechanisms VDAC1 oligomerization regulating are not well elucidated. Here, we identify that binding protein V-Set Transmembrane Domain Containing 2 Like (VSTM2L),...
Tumor-associated macrophages of the M2 phenotype promote cancer initiation and progression. Importantly, macrophage-derived exosomes play key roles in malignancy cells. Here, we report that circTMCO3 is upregulated ovarian patients, its high expression indicates poor survival. M2-derived proliferation, migration, invasion cancer, but these effects are abolished by knockdown circTMCO3. Furthermore, functions as a competing endogenous RNA for miR-515-5p to reduce abundance, thus upregulating...
The targeting protein for Xenopus kinesin-like 2 (TPX2) is associated with the metastasis and prognosis of bladder cancer. p53 closely related to progression Human glioma pathogenesis-related 1 (GLIPR1) a target gene antitumor activity. This study aims explore interplay between TPX2, p53, GLIPR1 its correlation cell proliferation, invasion, tumor growth in Here, Western blot qRT-PCR analysis revealed that TPX2 at both mRNA levels was up-regulated carcinoma tissues compared their paired...
The effects of taurine supplementation on the growth and intestinal immune function in young grass carp (Ctenopharyngodon idella) were investigated this study. A total 540 fish (initial average weights 255.74 ± 0.65 g) fed one fishmeal diet five all-plant protein source-based diets with graded levels (0 to 1.98g/kg diet) for 60 days, then challenged Aeromonas hydrophila 14 days. First, results showed that improved (PWG, TGC, FI FE), enteritis resistance, antimicrobial compounds (LZ, ACP, C3,...
Abstract Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons, and substantia nigra primarily one the damaged brain regions. Evidence indicates that microRNAs (miRNAs) involved in pathophysiology this disease. The present study aimed to investigate biological function miR‐326 PD through JNK signaling pathway targeting X‐box binding protein 1 (XBP1). After liposome complexes were prepared, healthy male C57BL/6 mice selected construct mouse model PD....
Abstract Recent findings have revealed the important roles of microRNAs (miRNAs) in secondary responses to oxidative damage caused by iron (Fe) excess. However, functional importance miRNAs plant Fe deficiency remains be explored. Here, we show that expression level miR164 Arabidopsis (Arabidopsis thaliana) roots was repressed deficiency. Primary root length, lateral number, ferric reductase activity, and mRNA abundance IRON-REGULATED TRANSPORTER1 (IRT1) FERRIC REDUCTION OXIDASE2 (FRO2) were...
ABSTRACT Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks degeneration, but underlying pathogenetic processes only partially understood. Using mice with a null mutation in transcription factor gene Mitf, which RPE deficiencies associated we evaluated role trophic factors secreted by homeostasis. In such mice, thickness outer nuclear layer (ONL) is as wild type up to postnatal day 10, then progressively reduced, marked increase number apoptotic cells decline staining...
miR-101-3p may play a therapeutic role in various tumours. However, its anti-tumour mechanism remains unclear, and definitive strategy to treat tumour cells vivo is lacking. The objective of this study was investigate the inhibitory on develop relevant nanomedicines for therapy. expression levels target protein TBLR1 tissues were detected, their relationship with ferroptosis clarified. Furthermore, efficacy nanocarriers achieving gene delivery evaluated. Nanomedicine further developed,...
Abstract Background Ainuovirine is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) for treatment of human immunodeficiency virus type 1 (HIV-1) infection. The safety profile and pharmacokinetics ainuovirine was characterized in healthy adults administered with single ascending dose.Table 1.Summary statistics pharmacokinetic parameters after oral doses participants. Data are expressed median ± standard deviation (min, max); AUC0–t, area under the plasma concentration-time curve...
Traditional fermented foods are known to offer cardiovascular health benefits. However, the potential of Chinese chives (FCC) in reducing coronary heart disease (CHD) remains unclear. This study employed anaerobic fermentation investigate Lactiplantibacillus plantarum (L. plantarum) P470 from FCC. The results indicated that L. enhanced hydroxyl radical scavenging and exhibited anti-inflammatory effects on RAW264.7 macrophages fecal supernatant CHD patients. These were attributed modulation...
Abstract Background Acute lung injury (ALI) is a severe and fatal respiratory disease. SIRT6 exerts pivotal activities in the process of diseases, but whether impacts ALI has not been covered. Methods Lentivirus recombinant expressing vector gene (Lent‐SIRT6) was constructed mice, there were control, lipopolysaccharide (LPS), LPS + Vehicle, Lent groups. RT‐qPCR western blot detected expression tissues. HE staining observed pathological alternations Wet‐to‐dry ratio lungs then measured. The...
Ovarian cancer (OC) is the leading cause of death among women with gynecologic malignant diseases, however, molecular mechanism ovarian not well defined. Previous studies have found that RNA binding protein Lin28A a key factor maintain pluripotency stem cells, and it positively correlated degree several cancers (breast, prostate, liver cancer, etc). Our previous study shows highly expressed in OC tissues involved regulation cell biological behavior. In this study, we confirmed high...
The present study investigated the feasibility of improving tumor‑targeting efficacy and decreasing toxicity liposomal cabazitaxel (Cab) with aptamer modification. process involved preparing (TLS1c)‑modified liposomes studying behavior in vitro vivo. TLS1c as an aptamer, which has high specificity for BNL 1ME A.7R.1 (MEAR) cells, was conjugated Cab (Cab/lipo) to enhance MEAR tumor tissue targeting. Confocal laser scanning microscopy flow cytometry analyses demonstrated that fluorescence...
Guanidine acetic acid (GAA) is a safe feed additive and the only precursor for creatine synthesis of vertebrates. Aeromonas hydrophila major fish pathogen causing severe morbidity mortality in aquaculture sector. Under current intensive farming system, A that can improve disease resistance urgently needed. In teleost fish, spleen (SP) head kidney (HK) play crucial role peripheral immunity organs skin (SK) serves as one most important mucosal barriers. Thus, study focused on immune defense...
As the most common subset of breast cancer (BC), estrogen receptor positive (ER+) BC accounting for 80% cases, has become a global public health concern. The female hormone (E2) unequivocally drives ER + malignancies. reasons that affects development long been considered, yet further study remains to be conducted molecular events in E2-estrogen α (ERα) signaling pathway progression, especially lipid metabolism, so providing more options tailored and individualized therapy. Our aim is find...