A5054527659- Connective tissue disorders research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Radiation Therapy and Dosimetry
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Aortic aneurysm repair treatments
- Pancreatic function and diabetes
- Prostate Cancer Treatment and Research
- RNA Interference and Gene Delivery
- Cellular Mechanics and Interactions
- Ultrasound and Hyperthermia Applications
- Angiogenesis and VEGF in Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Radiomics and Machine Learning in Medical Imaging
Duke University
2012-2024
Pratt Institute
2022-2024
Duke Medical Center
2015
St. Marianna University School of Medicine
2012
Radiopharmaceutical therapy (RPT) is an attractive strategy for treatment of disseminated cancers including those overexpressing the HER2 receptor breast, ovarian and gastroesophageal carcinomas. Single-domain antibody fragments (sdAbs) exemplified by HER2-targeted VHH_1028 evaluated herein are RPT because they rapidly accumulate in tumor clear faster from normal tissues than intact antibodies. In this study, was labeled using residualizing prosthetic agent N-succinimidyl 3-guanidinomethyl...
Brachytherapy is a common clinical technique involving implantation of sealed radioactive "seeds" within tumor to selectively irradiate the mass while minimizing systemic toxicity. To mitigate disadvantages associated with complex surgical and subsequent device removal procedures, we have developed an alternative approach using genetically encoded peptide polymer solution composed thermally responsive elastin-like polypeptide (ELP) radiolabeled (131)I that self-assembles into radionuclide...
Nab‐paclitaxel (Abraxane), an albumin‐bound solvent‐free paclitaxel (PTX) formulation that takes advantage of the endogenous albumin transport pathway, is current gold standard for treatment solid tumors with PTX. However, nab‐paclitaxel has several limitations, including complex manufacturing, immunogenicity, slow drug‐release, and a narrow therapeutic window. Nevertheless, no other PTX gained Food Drug Administration approval since Abraxane's 18‐year reign. Addressing these concerns,...
The development of platinum(Pt)-drugs for cancer therapy has stalled, as no new Pt-drugs have been approved in over a decade. Packaging small molecule drugs into nanoparticles is way to enhance their therapeutic efficacy. To date, there direct comparison relative merits the choice Pt oxidation state same nanoparticle system that would allow its optimal design. address this lacuna, we designed recombinant asymmetric triblock polypeptide (ATBP) self-assembles rod-shaped micelles and chelates...
Bioactive peptides describe a very large group of compounds with diverse functions and wide applications, their multivalent display by nanoparticles can maximize activities. However, the lack universal nanoparticle platform design rules for optimal presentation limits development application peptide ligand-decorated nanoparticles. To address this need, we developed to study impact surface hydrophilicity charge on targeting internalization tumor cells. This system consists micelles...
Abstract The intratumoral delivery of radioactive therapeutics, a clinical technique known as brachytherapy, has proven very successful in treating solid cancers and become prevalent option for prostate, breast, melanoma tumors. method typically involves the permanent implantation 80-120 titanium ‘seeds’ encapsulating isotopes requires expert spatial placement to ensure full dose coverage. disadvantages seeds include complicated process, permanence implants, migration off-target sites, that...
Abstract Pancreatic tumors remain one of the deadliest manifestations cancer in clinical oncology. Even when are diagnosed early, loco-regionalized, and receive cutting-edge treatment, 5-year survival rate remains less than 27%. This high mortality arises from significant biologic barriers that inhibit drug delivery effectiveness pancreatic tumors, as well their underlying genetic mutations confer resistance to traditional radiation chemotherapeutic standards care. In this work, we...
Purpose: To validate the use of a PRESAGE dosimeter as method to quantitatively measure dose distributions injectable brachytherapy based on elastin-like polypeptide (ELP) nanoparticles. is solid, transparent polyurethane-based whose proportional change in optical density, making it useful for visualizing from radionuclide-tagged-ELP injection. Methods: A was designed simulate an ELP calibrate, cuvette samples batch were exposed varying levels radiation 0–35.9Gy applied via linear...
<div>Abstract<p>Brachytherapy is a common clinical technique involving implantation of sealed radioactive “seeds” within tumor to selectively irradiate the mass while minimizing systemic toxicity. To mitigate disadvantages associated with complex surgical and subsequent device removal procedures, we have developed an alternative approach using genetically encoded peptide polymer solution composed thermally responsive elastin-like polypeptide (ELP) radiolabeled...
<div>Abstract<p>Brachytherapy is a common clinical technique involving implantation of sealed radioactive “seeds” within tumor to selectively irradiate the mass while minimizing systemic toxicity. To mitigate disadvantages associated with complex surgical and subsequent device removal procedures, we have developed an alternative approach using genetically encoded peptide polymer solution composed thermally responsive elastin-like polypeptide (ELP) radiolabeled...
Purpose: To develop, validate, and evaluate a methodology for determining dosimetry intratumoral injections of elastin‐like‐polypeptide (ELP) brachytherapy nanoparticles. These organic‐polymer‐based nanoparticles are injectable, biodegradable, genetically tunable. We present encoded polymer‐solution, composed novel radiolabeled‐ELP that custom‐designed to self‐assemble into local source upon injection. Our preliminary results small animal study demonstrate 100% tumor response, effective...
Abstract Brachytherapy seeds are made by sealing radionuclides in metal or other non-degradable material (resin glass) and surgically implanted into the tumor tissue. has shown some efficacy clinic for treatment of solid tumors. However, its application is limited due to side effects caused seed migration locally systemically, antitumor because spatial heterogeneity dose distribution, complicated surgical procedure implantation removal. In an attempt overcome these drawbacks, using thermally...
Abstract Brachytherapy continues to be one of the predominant radiotherapy modalities for treatment prostate cancer. Depending on stage cancer, it is employed either as a stand-alone or neoadjuvant therapy improve success surgical prostatectomy. Current clinical methods utilize titanium encased radioactive seeds, which must permanently implanted within prostate. The permanence seed problematic can lead urinary and sexual discomfort; while rarer, migrating seeds become entrapped in other...