A5101584028- Respiratory Support and Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Nosocomial Infections in ICU
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Spine and Intervertebral Disc Pathology
- Airway Management and Intubation Techniques
- Medicinal Plant Pharmacodynamics Research
- Bone Metabolism and Diseases
- interferon and immune responses
- Tracheal and airway disorders
- Lower Extremity Biomechanics and Pathologies
- TGF-β signaling in diseases
- Tumors and Oncological Cases
- Spondyloarthritis Studies and Treatments
- Oral and Maxillofacial Pathology
- Plant Toxicity and Pharmacological Properties
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
Capital Medical University
2020-2023
Beijing Children’s Hospital
2022-2023
Tianjin Medical University General Hospital
2013-2022
Beijing Institute of Neurosurgery
2000-2022
Beijing Chao-Yang Hospital
2020-2022
Capital Health
2020
Capital District Health Authority
2020
Jiangsu University
2010
Tianjin Medical University
2009
Previous studies have suggested that adjusting ventilator settings based on transpulmonary pressure measurements may minimize ventilator-induced lung injury, but this has never been investigated in patients with severe acute respiratory distress syndrome supported venovenous extracorporeal membrane oxygenation. We aimed to evaluate whether a pressure-guided ventilation strategy would increase the proportion of successfully weaned from oxygenation support syndrome.Single-center, prospective,...
Introduction: Currently, there is a lack of evidence on the utilization high-flow nasal cannula (HFNC) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) accompanied by hypercapnic respiratory failure. We aimed to explore efficacy and safety HFNC compared conventional oxygen therapy (COT) such patients. Methods: This was prospective, randomized, controlled trial. Patients AECOPD baseline arterial blood gas pH ≥ 7.35, PaO 2 < 60 mmHg, PaCO > 45 mmHg were...
Abstract Background Hypoxemia frequently occurs during bronchoscopy. High-flow nasal cannula (HFNC) oxygen therapy may be a feasible alternative to prevent the deterioration of gas exchange With convenience clinical use in mind, we modified an HFNC using single cannula. This trial was designed test hypothesis that would decrease proportion patients with moment peripheral arterial saturation (SpO 2 ) < 90% Methods In this single-center, prospective randomized controlled trial, hospitalized...
TANK-binding kinase 1 (TBK1) was previously reported to be critical for the regulation of osteoclast differentiation. However, its function in osteoarthritis (OA) has not yet been determined. This study aims reveal role TBK1 extracellular matrix (ECM) degradation OA. C57BL/6 J mice were subjected anterior cruciate ligament transection (ACLT) surgery establish an OA animal model. ATDC5 cells treated with IL-1β construct a cell model Changes expression analyzed by qRT-PCR, Western blotting,...
Abstract Background Intervertebral disc degeneration (IDD) is the main cause of low back pain. Patients with pain may experience significant socio-economic burdens and decreased productivity. Previous studies have shown that inflammation one causes IDD. Astragaloside IV (AS IV), a traditional Chinese medicine, has been reported to therapeutic effects on many inflammation-related diseases; however, effectiveness AS as treatment for IDD not studied. Methods Nucleus pulposus (NP) cells from...
The purpose of this study was to investigate the role Icariine on expression Smadl and Smad5 mRNA protein levels in MC3T3-E1 cells vitro. were cultured presence different concentrations (0, 10, 40 80 ng/ml). Smad1 detected by reverse transcription-polymerase chain reaction (RT-PCR) proteins determined western blotting, immunohistochemistry staining immunofluorescence. continuously increased ng/ml with time differences indicated statistical significance. Western blot analysis demonstrated...
Objective This study aimed to analyze age-specific characteristics of childhood-onset systemic lupus erythematosus (cSLE) at a health center in China. Methods The children with SLE were grouped based on age disease-onset: pre-pubertal (≤7 years), peri-pubertal (8–13 and adolescence (14–18 years). retrospective included patients cSLE diagnosed the Beijing Children’s Hospital between 2013 2021. Results A total 675 females 178 males eligible for inclusion this study. Among them, 160 during...
Abstract Background Following endotracheal intubation, clearing secretions above the tube cuff decreases incidence of ventilator-associated pneumonia (VAP); therefore, subglottic secretion drainage (SSD) is widely advocated. Our group developed a novel technique to remove secretions, rapid-flow expulsion maneuver (RFEM). The objective this study was explore effectiveness and safety RFEM compared with SSD. Methods This single-center, prospective, randomized controlled trial, conducted at...
Articular cartilage and subchondral bone changes during the pathological progress of knee osteoarthritis (KOA) is a key event marking development disease. The age varying alteration patterns within entire osteochondral unit remains poorly understood. purpose this study was to find reasonable range Dunkin-Hartley guinea pig model for studying KOA process, investigate Intraosseous pressure (IOP) in process different degeneration stages KOA.Male pigs were selected divided into groups 3, 6, 9,...
Objective To explore the effect of icariin on expression Smad1, 5 mRNA and protein Smad3, in MC3T3-E1 cells vitro. Methods According to stimulus concentrations (0, 30, 40 80 ng/ml) icariin, were divided into four groups. After stimulated by 24, 48 72 h, RT-PCR was used detect level about 5. Western blot technique applied exsplore expression. The immunohistochemistry engaged comfirm localize cells. All data treated with One-way Anova analysis Dunnett-t test SPSS 13.0 software. Results inariin...
The cuff leak test (CLT) has been shown to have excellent specificity and moderate sensitivity for predicting postextubation stridor (PES). However, the ventilator flow waveform subject position are not uniform in current clinical practice.We conducted a prospective cohort study respiratory ICU of Beijing Chaoyang Hospital, Capital Medical University. Prior extubation, 4 CLTs, combining 2 different postures waveforms, were conducted, diagnostic performance each was assessed.Of 143 included...
Objective: To investigate the clinical and pathological features of salivary secretory carcinoma (SSC). Methods: Ten cases SSC confirmed in Department Pathology,Capital Medical University School Stomatology from January 2014 to December 2021 were retrospectively included, including 5 males females, with a median age 46.5 years. The microscopic morphology, immunophenotype, special staining follow-up 10 observed. patients tested S-100, vimentin, mammaglobin, Dog-1, p63 Ki-67, 9 cytokeratin...