A5027879311- melanin and skin pigmentation
- RNA regulation and disease
- Skin Protection and Aging
- Asymmetric Synthesis and Catalysis
- Biochemical Analysis and Sensing Techniques
- Genetic and rare skin diseases.
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Atherosclerosis and Cardiovascular Diseases
- Ionic liquids properties and applications
- Olfactory and Sensory Function Studies
- Skin and Cellular Biology Research
- Garlic and Onion Studies
- Mast cells and histamine
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Chemical Reactions and Isotopes
- Ocular Oncology and Treatments
- Protein Tyrosine Phosphatases
- Histiocytic Disorders and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Advancements in Transdermal Drug Delivery
- Hedgehog Signaling Pathway Studies
- Rabbits: Nutrition, Reproduction, Health
- Polydiacetylene-based materials and applications
Yamagata University
2009-2024
Sojo University
2023
Kyoto Institute of Technology
2020
Tohoku University
2010-2013
Tohoku Medical and Pharmaceutical University
2009
Komatsu (Japan)
2009
keiyu Hospital
1988
Beijing Red Cross Blood Center
1984
Shizuoka Red Cross Hospital
1984
Abstract We investigated whether carboxylic acid-terpene-based deep eutectic solvents (DESs) can be used as skin permeation enhancers. performed transdermal experiments, and their results showed that DESs with longer hydrocarbon chains enhance the permeability of hydrophilic fluorescein sodium hydrophobic meloxicam. Additionally, all could improve poorly soluble resveratrol. Subsequently, we evaluated stratum corneum’s structural transition after applying DESs. The l-menthol-based disrupt...
Organocatalytic functionalization of heteroaromatic N-oxides was investigated using in situ generated onium amide bases, and C-nucleophiles were efficiently introduced by the sequential addition–elimination reaction under metal-free conditions, affording 2-substituted nitrogen heteroaromatics generally good to high yields.
Functionalisation of quinoline N-oxide was investigated using phophazene base as a catalyst; alkynylation and heteroarylation at 2-position were successfully achieved via nucleophilic addition-elimination process.
Summary Hermansky–Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by oculocutaneous albinism (OCA), a bleeding tendency, and ceroid deposition. Most of the causative genes for HPS encode subunits biogenesis lysosome‐related organelles complex (BLOC). In this study, we identified one patient each with HPS4, HPS6, HPS9 whole‐exome sequencing. Next, analyzed hair samples from three patients representative HPS1 controls using electron microscopy chemical methods. All had...
SASH1 has been reported as a causal gene of lentiginous phenotypes with and without heredity, including an autosomal dominant type characterized by lentigines predominantly on sun-exposed areas such the face limbs. Recently, cases dyschromatosis mutations have worldwide; however, only one case from Japan. Here, we analyzed six Japanese patients who characteristically showed many areas, using next-generation sequencing. We identified five novel heterozygous in (p.I586M, p.S531Y, p.R644W,...
Abstract Background Acquired skin hypopigmentation has many etiologies, including autoimmune melanocyte destruction, aging, inflammation, and chemical exposure. Distinguishing lesions from normally pigmented is clinically important to precisely assess disease severity. However, no gold standard assessment method been reported. We aimed investigate whether spectrophotometers are useful for assessing vitiligo rhododendrol (4‐(4‐hydroxyphenol)‐2‐butanol) (Rhododenol ® )‐induced leukoderma...
Two patients and a healthy blood donor were found to be Lan negative have anti‐Lan in their sera. These are the first three examples of Lan‐negative phenotype described Japanese. The families two propositi studied: parents both cousins one had sibling. No Lan‐ 15,000 Japanese donors screened with anti‐Lan.
Chiral cationic palladium-BINAP catalyst in ionic liquid showed an excellent asymmetric catalytic activity the Diels-Alder reactions using several dienes and was easily recycled 7 times with good chemical yield enantioselectivity (50-60%, 94-98% ee).
Racemic RS-4-(4-hydroxyphenyl)-2-butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin-lightening cosmetics, was unexpectedly reported Japan to induce leukoderma or vitiligo called RD-induced (RIL) after repeated application. To our knowledge, no studies have investigated chemical-induced pathogenesis on a genome-wide scale. Here, we conducted association study (GWAS) for 147 cases and 112 controls. CDH13, encoding glycosylphosphatidylinositol-anchored protein...
A novel ratiometric assay was developed for the accurate and facile quantification of nucleic acids using a combination surface-enhanced Raman scattering (SERS) two kinds bioorthogonal reporters attached to SERS probes. Normalization intensities phenylethynylphenyl group by ethynylphenyl allows automatic target DNA down 86 pM. kind (N-(4-ethynylphenyl)-3-mercaptopropanamide (EP) as an internal standard 3-mercapto-N-[4-(2-phenylethynyl)phenyl]propenamide (PEP) responsive reporter). targeted
Background Vitiligo is an acquired pigmentary disorder characterized by depigmented patches on the skin that majorly impact patients' quality of life. Although its etiology involves genetic and environmental factors, role microorganisms as factors in vitiligo pathology remains under-researched. Objectives Our study explored presence characteristic bacterial fungal flora vitiligo-affected investigated their potential roles pathogenesis. Methods We sequenced 16 S rRNA ITS1 region from swabs...