A5070369844- Marine Sponges and Natural Products
- Marine Biology and Environmental Chemistry
- Environmental Toxicology and Ecotoxicology
- Microbial Natural Products and Biosynthesis
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Marine and coastal plant biology
- Microplastics and Plastic Pollution
- biodegradable polymer synthesis and properties
- Air Quality and Health Impacts
- Chromosomal and Genetic Variations
- Ocean Acidification Effects and Responses
- Algal biology and biofuel production
- Marine Bivalve and Aquaculture Studies
- Marine Toxins and Detection Methods
- Genomics and Chromatin Dynamics
- Echinoderm biology and ecology
- Aquaculture Nutrition and Growth
- Seaweed-derived Bioactive Compounds
- Coral and Marine Ecosystems Studies
- Aquaculture disease management and microbiota
- Protist diversity and phylogeny
- RNA modifications and cancer
- Toxic Organic Pollutants Impact
- RNA Research and Splicing
Stazione Zoologica Anton Dohrn
2016-2025
Institute of Biosciences and Bioresources
2017-2022
National Research Council
2021-2022
Park Plaza Hospital
2022
Health Effects Institute
1993-2019
University of Michigan
1990
University of Toledo Medical Center
1983-1984
National Cancer Institute
1981
Isochores are large DNA segments (>>300 kb on average) that characterized by an internal variation in GC well below the full seen mammalian genome. Precisely defining terms of size and composition as mapping isochores human chromosomes have, however, remained largely unsolved problems. Here we used a very simple approach to segment de novo, based assessments its within between adjacent regions. We obtain complete coverage genome (neglecting remaining gaps) approximately 3200 isochores, which...
Monitoring of aquatic ecosystems has been historically accomplished by intensive campaigns direct measurements (by probes and other boat instruments) indirect extensive methods such as aero-photogrammetry satellite detection. These characterized the research in last century, with significant but limited improvements within those technological boundaries. The newest advances field smart devices increased networking capabilities provided emerging tools, Internet Things (IoT), offer increasing...
Previous work from our laboratory showed that (i) vertebrate genomes are mosaics of isochores, typically megabase-size DNA segments fairly homogeneous in base composition; (ii) isochores belong to a small number families (five the human genome) characterized by different GC levels; (iii) isochore family patterns fishes/amphibians and mammals/birds, latter showing GC-rich absent or very scarce former; (iv) there two modes genome evolution, conservative one which basically do not change (e.g.,...
Sirtuins genes are widely distributed by evolution and have been found in eubacteria, archaea eukaryotes. While prokaryotic archeal species usually one or two sirtuin homologs, humans as well eukaryotes we multiple versions mammals this family is comprised of seven different homologous proteins being all NAD-dependent de-acylases. 3D structures human SIRT2, SIRT3, SIRT5 revealed the overall conformation conserved core domain but they were unable to give a structural information about...
Acute respiratory effects of low-level ozone exposure are not well defined in older adults.MOSES (The Multicenter Ozone Study Older Subjects), although primarily focused on acute cardiovascular effects, provided an opportunity to assess responses low concentrations healthy adults.We performed a randomized crossover, controlled study 87 adults (59.9 ± 4.5 yr old; 60% female) 0, 70, and 120 ppb for 3 hours with intermittent exercise. Outcome measures included spirometry, sputum markers airway...
The evidence that exposure to ozone air pollution causes acute cardiovascular effects is mixed. We postulated ambient levels of would increase blood markers systemic inflammation, prothrombotic state, oxidative stress, and vascular dysfunction in healthy older subjects, absence the glutathione S-transferase Mu 1 (GSTM1) gene confer increased susceptibility. This double-blind, randomized, crossover study 87 volunteers 55–70 years age was conducted at three sites using a common protocol....
Sponge farming has been experimentally performed for more than 100 years, with early attempts mainly devoted the supply of bath sponges and ornamental purposes. During last decades, sponge proposed to produce biomass specifically those species from which many structurally diverse bioactive compounds were isolated, frequently present in a low concentration that limits their commercial production. This point is very important because it offers an environmental-friendly approach use as source...
Chromosome replication timing is biphasic (early-late) in the cell cycle of vertebrates and most (possibly all) eukaryotes. In present work we have compared extended, detailed maps that are available, namely those human chromosomes 6, 11q, 21q, with chromosomal bands as visualized at low (400 bands), high (850 highest (3,200 isochores) resolution. We observed replicons located a given isochore practically always show either all early or late early-replicating isochores short GC-rich...
Diatoms are ubiquitous and abundant primary producers that have been traditionally considered as a beneficial food source for grazers the transfer of carbon through marine webs. However, many diatom species produce polyunsaturated aldehydes disrupt development in offspring feed on these unicellular algae. Here we provide evidence production physiological messenger nitric oxide increases after treatment with aldehyde decadienal embryos sea urchin Paracentrotus lividus. At high concentrations,...
Many diatom species produce polyunsaturated aldehydes, such as decadienal, which compromise embryonic and larval development in benthic organisms. Here newly fertilized Paracentrotus lividus sea urchins were exposed to low concentration of decadienal the expression levels sixteen genes, implicated a broad range functional responses, followed by Real Time qPCR order identify potential targets. We show that at concentrations urchin places motion different classes genes defend itself against...