A5018317647- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Ectopic Pregnancy Diagnosis and Management
- Gynecological conditions and treatments
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Endometrial and Cervical Cancer Treatments
- Minimally Invasive Surgical Techniques
- Ovarian cancer diagnosis and treatment
- Sperm and Testicular Function
- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Pregnancy and Medication Impact
- Gestational Trophoblastic Disease Studies
- COVID-19 Impact on Reproduction
- Folate and B Vitamins Research
- Maternal and fetal healthcare
- Family Support in Illness
- Pelvic floor disorders treatments
- Cancer Risks and Factors
- Bone health and osteoporosis research
- Renal and related cancers
Fukushima Medical University
2018-2024
Tokyo Rosai Hospital
2022-2024
Kawasaki Medical School
2024
Kameda Medical Center
2023-2024
Toho University
2011-2022
Yamaguchi Red Cross Hospital
2016-2022
Center for Children
2019-2022
Rosalind Franklin University of Medicine and Science
2012-2020
Red Cross Hospital
2016-2018
Keio University
2014-2017
Do women with recurrent pregnancy losses (RPL) and low vitamin D have increased prevalence of auto- cellular immune abnormalities when compared RPL who normal D, does any effect on immunity in vitro? A high proportion deficiency the risk is deficiency. Vitamin deficiency pregnant associated obstetrical complications such as pre-eclampsia, bacterial vaginosis preterm delivery, gestational diabetes mellitus small-for-gestational age births. retrospective cross-sectional study 133 were enrolled...
We evaluated the clinical efficacy of immunosuppressive treatment with tacrolimus for repeated implantation failure (RIF) patients who have elevated in T helper (Th1)/Th2 cytokine producing cell ratios.This was a prospective cohort study RIF (n = 42) peripheral blood Th1 (CD4(+) /IFN-γ(+) )/Th2 /IL-4(+) ) ratios at Sugiyama clinic between November 2011 and October 2013. Twenty-five were treated (treatment group) 17 received no (control group). Treatment group 2 days before embryo transfer...
Vitamin D has a pivotal role in regulating immune responses by promoting Th2 and suppressing Th1 responses. Propensities to response increased NK-cell levels cytotoxicity have been reported women with recurrent pregnancy losses (RPL). In RPL, vitamin deficiency is prevalent; however, the effect of on NK cells largely unknown. this study, we demonstrated that CD69(+) activating receptor expression was significantly decreased incubation 1,25(OH)2 D3 dose-dependent manner, while CD158a CD158b...
Copper/zinc superoxide dismutase (CuZn-SOD, SOD1) is one of the major antioxidant enzymes, and localized in cytoplasm to scavenge superoxide. To investigate physiological role SOD1 ovaries, we analyzed fertility Sod1-deficient female mice. evaluate their hormonal metabolism, measured pituitary ovarian hormone levels plasma mutant Plasma follicle-stimulating hormone, luteinizing estradiol were not altered compared wild-type females, while progesterone level was significantly reduced females....
Abstract STUDY QUESTION Is there any relationship between vitamin D [25 (OH) D], total plasma homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in women with recurrent pregnancy losses (RPL)? SUMMARY ANSWER Women MTHFR 677TT (homozygous mutation, TT) genotype have significantly lower levels, higher natural killer (NK) cell cytotoxicities than those of 677CC (wild type, CC) 677CT (heterozygous CT) genotypes. WHAT IS KNOWN ALREADY Vitamin insufficiency,...
Oxidative stress (OS) affects men’s health and impairs spermatogenesis. Micronutrient antioxidants are available for male infertility as complemental support; however, their efficacy remains debatable. This study aimed to investigate whether can help reduce sperm OS improve semen analysis quality. We included 171 partners of couples planning undergo assisted reproductive technology (ART). Male partners, aged 29–41 years, intending conceive were self-selected take daily (n = 84) containing...
Repeated and dramatic pregnancy-induced uterine enlargement remodeling throughout reproductive life suggests the existence of smooth muscle stem/progenitor cells. The aim this study was to isolate characterize stem/progenitor-like cells from human myometrium through identification specific surface markers. We here identify CD49f CD34 as markers permit selection cell-like population show that CD45– CD31– glycophorin A– CD49f+ CD34+ myometrial exhibit stem properties. These include side...
Homocysteine is an amino acid naturally produced in the body and metabolized via methionine cycle. High homocysteine levels can increase risk of infertility pregnancy complications, such as preeclampsia, preterm delivery, miscarriage, low birth weight. Preconceptional may be reduced by taking folic supplements to reduce complications. This cross-sectional, hospital-based study was conducted examine role 1060 infertile women with a history IVF/intracytoplasmic sperm injection (ICSI) failure....
Background A number of laboratory tests have been developed to determine properties spermatozoa quality but few adopted into routine clinical use in place the WHO semen analysis. We investigated whether Atp6v0a2 (a2 isoform vacuolar ATPase) is associated with abnormal and changes chemokine-cytokine profiles infertile men. Patients Methods Semen samples were collected from 35 healthy donors men at Andrology August 2011 June 2012. The levels mRNA protein, its localization determined. a2NTD...
Abstract Introduction Laparoscopic surgery is a minimally invasive surgery, and the rate of postoperative adhesions low. Although Seprafilm® helps to reduce adhesions, its application in abdominal cavity during laparoscopic difficult because material. Therefore, we propose an easy method for applying this adhesion barrier. Materials Surgical Technique The Seprafilm cut into four equal pieces. pieces are stacked, firmly folded twice, grasped with forceps. reducer sleeve slid over bundle...
Abstract Background Endometrial receptivity array (ERA) is used to determine the timing of embryo transfer (ET) synchronized with window implantation (WOI). The effectiveness and evaluation ERAs in women recurrent failure remain controversial. We report case a patient that raises issue reproducibility ERA tests. Case A 36-year-old Japanese woman secondary infertility who had previously given birth failed conceive after three frozen-thawed (FET) cycles. An test was conducted confirm WOI....
This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed directors 695 institutes where cryopreservation might be performed with questionnaires requesting information on number patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, success rate, causes unsuccessful cryopreservation. Of these institutes, 92 had cryopreserved before chemotherapy within period. In all, 820 patients (237...
Prevention of subsequent primary cancer (SPC) is crucial for survivors, particularly those who developed the disease during childhood, adolescence, and young adulthood (CAYA). The aim this study was to assess current status SPC prevention among female CAYA survivors.
Robotic simple hysterectomy (RSH) is the most common robotic gynecologic surgery in United States. Uterine manipulators are commonly used to handle uterus during laparoscopic surgery, but few studies have examined their necessity RSH. This study retrospectively compares RSH cases with and without use of manipulators, identifies predictors for intraoperative use.
Objective Adenomyosis-related infertility is increasingly being diagnosed, and surgical intervention has been suggested to improve fertility. Elastography, a noninvasive ultrasound technique, promising for diagnosing guiding the resection of adenomyosis. This report presents first case successful delivery after twin pregnancies achieved with IVF following intraoperative elastography-guided laparoscopic adenomyomectomy. Case A 35-year-old Japanese woman uterine adenomyosis received...
Abstract Aim Menorrhagia and dysmenorrhea are common symptoms. Uterine adenomyosis is one of the causes menorrhagia dysmenorrhea. These symptoms often decrease quality life in women. Microwave endometrial ablation (MEA) a recently developed procedure that enables ablation. Dienogest has long been used to suppress endometrium development reduce adenomyosis‐related However, some cases could be resistant dienogest. In this study, we evaluated efficacy combination MEA postoperative dienogest...
Objective The purpose of this survey was to assess the prevalence genital and urinary tract symptoms among Japanese women with declining estrogen levels.Methods A health-related questionnaire conducted in their 40s or older inquire about genital, intercourse-related, concern over symptoms.Results Of consecutive 10,000 respondents recruited, 4488 (44.9%) reported having symptoms: 3546 (79.0%) expressed symptoms. Furthermore, 2173 (21.7%) had incontinence, 1999 (20.0%) frequency, 1648 (16.5%)...
Abstract Background Endometriosis can potentially lead to the development of a malignant tumor. Most tumors arising from endometriosis originate ovarian endometrioma, whereas those extragonadal lesions are rare. We report rare case endometrioid carcinoma that developed deep infiltrating in uterosacral ligament 6 years after treatment for atypical proliferative tumor ovary 48-year-old woman. Case presentation Six ago, patient underwent laparoscopic bilateral salpingo-oophorectomy her right...
We examined whether a new suturing method that used single-thread unidirectional barbed suture without exposing the barbs on wound surface was acceptable compared with conventional during laparoscopic myomectomy (LM).This retrospective study. The subjects were 26 women who underwent LM for symptomatic uterine fibroids. operative time, amount of blood loss, and number threads between group in which performed synthetic absorbable (conventional group, n = 13) using (barbed 13).Operative time...
The actual status of fertility preservation treatments in the startup phase Japan was investigated as a basis for discussing future directions.This study conducted "Research project to promote support children and parenting 2016" which supported by Ministry Health with approval institutional review board at St. Marianna University. Subjects survey were facilities registered Society Obstetrics Gynecology facilities, belonging Association Private Assisted Reproductive Technology Clinics...
Purpose: Fertility preservation (FP) is becoming increasingly common among child, adolescent, and young-adult (CAYA) patients with cancer. However, Japan has long lacked definite estimates of utilization rates for FP services CAYA cancer, little known about disease/FP outcomes users. Therefore, the Society Preservation (JSFP) launched Oncofertility Registry (JOFR) in 2018 started online registration information regarding primary disease, FP, data on prognosis pregnancy outcomes. This study...