A5042592046- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Molecular Biology Techniques and Applications
- Inflammatory Bowel Disease
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
- Bioinformatics and Genomic Networks
- Cancer therapeutics and mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Drug Transport and Resistance Mechanisms
- Metastasis and carcinoma case studies
- Kruppel-like factors research
- Genomic variations and chromosomal abnormalities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- DNA Repair Mechanisms
- Hepatitis B Virus Studies
- Gene expression and cancer classification
- HIV/AIDS drug development and treatment
The University of Queensland
2015-2024
Pfizer (United States)
2018-2023
Queensland Health
2017
QIMR Berghofer Medical Research Institute
2017
Brisbane School of Theology
2016
Abstract Breast cancer (BC) in the Asia Pacific regions is enriched younger patients and rapidly rising incidence yet its molecular bases remain poorly characterized. Here we analyze whole exomes transcriptomes of 187 primary tumors from a Korean BC cohort (SMC) pre-menopausal perform systematic comparison with primarily Caucasian post-menopausal (TCGA). SMC harbors higher proportions HER2+ Luminal B subtypes, lower proportion A decreased ESR1 expression compared to TCGA. We also observe...
Abstract To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole transcriptome profiling coupled with histopathology analyses a longitudinal breast cancer cohort 146 patients including 110 pairs serial tumor biopsies collected before treatment, after first cycle treatment and at time surgery. Here, show that cytotoxic chemotherapies induce dynamic changes in immune microenvironment vary by subtype pathologic response. Just one induces an stimulatory harboring more...
Invasive lobular carcinoma (ILC) is the most common special type of breast cancer, and characterized by functional loss E-cadherin, resulting in cellular adhesion defects. ILC typically present as estrogen receptor positive, grade 2 cancers, with a good short-term prognosis. Several large-scale molecular profiling studies have now dissected unique genomics ILC. We undertaken an integrative analysis gene expression DNA copy number to identify novel drivers prognostic biomarkers, using...
Breast cancer metastasis to gynaecological organs is an understudied pattern of tumour spread. We explored clinico-pathological and molecular features these metastases better understand whether this dissemination organotropic or a consequence wider metastatic dissemination. Primary tumours from 54 breast patients with were analysed using immunohistochemistry, DNA copy-number profiling, targeted sequencing 386 cancer-related genes. The median age primary diagnosis amongst was significantly...
We apply a network approach to identify genes associated in<italic>cis</italic>or in<italic>trans</italic>with copy-number alterations in breast cancer pathogenesis.
Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but how these features co-evolve remains unclear. SOX10 a neural crest stem cell (NCSC) specifier candidate mediator of plasticity in cancer. We investigated its relevance breast cancer immunophenotyping 21 normal 1860 tumour samples. Nuclear was detected mammary luminal progenitor cells, the histogenic origin most TNBCs. In tumours, nuclear almost exclusive to TNBC, predicted poorer outcome amongst...
Abstract Invasive Lobular Carcinoma (ILC) is the most common special histological subtype of breast cancer. ILC typically present as Oestrogen and Progesterone Receptor positive cancers, without over-expression HER2 are defined by their invasive pattern growth. Despite clinical biological differences, including diverse sites metastasis, managed in same way more commonly diagnosed, Carcinomas no type. Previously, we derived LobSig lobular specific gene signature an attempt to prognosticate...
Fibroblasts play a key role in stricture formation Crohn's disease (CD) but understanding it's pathogenesis requires systems-level investigation to uncover new treatment targets. We studied full thickness CD tissues characterize fibroblast heterogeneity and function by generating the first single cell RNA sequencing (scRNAseq) atlas of strictured bowel providing proof principle for therapeutic target validation.
A bstract Background Intratumoural heterogeneity is a poor prognostic feature in triple-negative breast cancer (TNBC) and other high-grade malignancies. It caused by genomic instability phenotypic plasticity, but how these features co-evolve during tumour development remains unclear. SOX10 transcription factor, neural crest stem cell (NCSC) specifier candidate mediator of cancer-associated plasticity. Methods Using immunophenotyping, we investigated the expression normal human tissue (n=21...
Abstract Background: Invasive lobular carcinoma (ILC) is the most commonly diagnosed special histological type of breast cancer, accounting for up to 15% all cases. Accumulating data suggests biology and clinical features ILC differ those more Carcinoma No Special Type (IC-NST), including evidence there being an overall worse long term outcome associated with ILC. Several large-scale molecular profiling studies have recently been published regarding ILC, highlighting heterogeneity important...
The molecular bases underlying neoadjuvant chemotherapy (NAC) response are poorly understood. To elucidate the effects of NAC on breast tumor biology and its association with clinical outcome, we have conducted WES RNA-Seq profiling a longitudinal cancer (BC) cohort consisting 146 cases (281 tumors, 109 pairs), including 55 (38%) that achieved pathologic complete responses (pCR) 91 (62%) harbored residual diseases at time surgery. Tumor biopsies were collected for each patient three points -...
Searchable abstracts of presentations at key conferences in oncology ISSN 2631-4657 (online)