A5014814088- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Mechanisms of cancer metastasis
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- TGF-β signaling in diseases
- Autoimmune and Inflammatory Disorders
- Single-cell and spatial transcriptomics
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Mast cells and histamine
- NF-κB Signaling Pathways
- Neonatal and fetal brain pathology
- Child Nutrition and Feeding Issues
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Glycogen Storage Diseases and Myoclonus
- interferon and immune responses
- MRI in cancer diagnosis
- Vietnamese History and Culture Studies
Pfizer (United States)
2011-2023
University of Florida
2023
Institut de Neurobiologie de la Méditerranée
2019
Aix-Marseille Université
2019
Ferrari (Italy)
2010
University of Miami
1981-2010
Petra Christian University
2006
Dana-Farber Cancer Institute
2002
Harvard University
2002
Thomas Jefferson University
1995-2001
Chronic myelogenous leukemia evolves in two clinically distinct stages: a chronic and blast crisis phase. The molecular changes associated with phase to transition are largely unknown. We have identified cDNA clone, DR-nm23, differentially expressed blast-crisis library, which has approximately 70% sequence similarity the putative metastatic suppressor genes, nm23-H1 nm23-H2. deduced amino acid proteins encoded by these latter genes is 65% includes domains residues (the leucine zipper-like...
c-Myb, the cellular homologue of transforming gene avian myeloblastosis virus, is preferentially expressed in all hematopoietic lineages, including T and B lymphocyte lineages. In lymphocytes, c-Myb expression appears to be required for cell cycle progression proliferation. To further investigate role proliferation survival, interleukin (IL) 2-dependent CTLL-2 cells were transfected with a constitutively active c-myb or antisense construct able down-regulate endogenous Myb levels,...
BV-265, a BMP-2/BMP-6/activin A chimera, delivered in composite matrix generates bone repair nonhuman primates at lower concentrations than BMP-2.
Blastic transformation of chronic myelogenous leukemia (CML) is characterized by the presence nonrandom, secondary genetic abnormalities in majority Philadelphia 1 clones, and loss p53 tumor suppressor gene function a consistent finding 25–30% CML blast crisis patients. To test whether functional plays direct role transition phase to crisis, bone marrow cells from +/+ or −/− mice were infected with retrovirus carrying either wild-type BCR/ABL inactive kinase-deficient mutant, assessed for...
ICSBP (IRF-8) is a transcription factor of the IRF family expressed only in immune system. It induced macrophages by gamma interferon (IFN-gamma) and contributes to macrophage functions. By interacting with Ets protein PU.1, binds IRF/Ets composite element stimulates transcription. another DNA element, IFN-stimulated response (ISRE), common target family. Limited knowledge as how other proteins regulate ISRE-dependent IFN-gamma-activated available. mass-spectrometric analysis ISRE-bound...
Background Liver biopsy is the reference standard to diagnose nonalcoholic steatohepatitis (NASH) but invasive with potential complications. Purpose To evaluate molecular MRI type 1 collagen–specific probe EP-3533 and allysine-targeted fibrogenesis Gd-Hyd, MR elastography, native T1 characterize fibrosis assess treatment response in a rat model of NASH. Materials Methods was performed prospectively (June–November 2018) six groups male Wistar rats (a) age- (b) weight-matched animals received...
Background: Neuroblastoma, a childhood tumor originating from cells of the embryonic neural crest, retains ability to differentiate, yielding with epithelial-Schwann-like, neuronal, or melanocytic characteristics. Since nm23 gene family members have been proposed play role in cellular differentiation, as well metastasis suppression, we investigated whether and how DR-nm23, recently identified third member human family, might be involved neuroblastoma differentiation. Methods: Three cell...
Nm23 gene family has been associated with metastasis suppression and differentiation. We studied DR-nm23 during neuroblastoma cells expression increased after retinoic acid induction of differentiation in human cell lines SK-N-SH LAN-5.In several lines, overexpression was more differentiated phenotypes. vimentin expression, deposition collagen type IV, modulated integrin underwent growth arrest; the murine line N1E-115 showed neurite outgrowth a striking enhancement beta1 expression....
Abstract The anatomic, cultural, and legal aspects of Santeria, a religious cult African origin, as experienced by the Dade County Medical Examiner's Office, are presented. Human skeletal parts generally found in association with an obvious ritual or may be discovered shallow graves. Their ritualistic use is often suggested their pennies, chicken feathers, evidence prolonged internment, rust, accoutrements characteristic cult. Although some specimens were obviously purchased previously used...
Studies conducted in human and rodent models have suggested that preexisting neurodevelopmental defects could predispose immature brains to febrile seizures (FS). However, the impact of anatomical extent cortical malformations on FS susceptibility was never assessed. Here, we induced hyperthermic (HS) rats with bilateral subcortical band heterotopia (SBH) found variable degrees HS depending inter-individual differences size SBH. This indicates an association exists between overall or...
Fibroblasts play a key role in stricture formation Crohn's disease (CD) but understanding it's pathogenesis requires systems-level investigation to uncover new treatment targets. We studied full thickness CD tissues characterize fibroblast heterogeneity and function by generating the first single cell RNA sequencing (scRNAseq) atlas of strictured bowel providing proof principle for therapeutic target validation.
Pompe disease is a monogenic neuromuscular disorder caused by mutation in the gene encoding lysosomal enzyme acid alpha-glucosidase. This leads to widespread glycogen accumulation, cardiorespiratory failure, and early mortality. There clear evidence for neurodegeneration neuroinflammation animal models of (Turner et al., Resp. Phys. Neurobio., 2016) as well human tissues (Fuller J. Neurophys., 2021). However, appearance microglia has not been comprehensively evaluated disease. Here we...
Abstract Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL), carrying the e1a2 fusion BCR/ABL oncogene, is typically an aggressive B cell leukemia, often resistant to current treatment options. The transcription factor c-Myb plays a critical role in development, but its unknown. To study of BCR/ABL-induced we compared disease induction, latency and survival mice expressing transgene knockout versus wild-type background. BCR/ABL+Myb+/− show distinct leukemia-resistant...