A5077051287- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Cancer Mechanisms and Therapy
- CRISPR and Genetic Engineering
- Microtubule and mitosis dynamics
- Calpain Protease Function and Regulation
- Melanoma and MAPK Pathways
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- E-commerce and Technology Innovations
- T-cell and B-cell Immunology
- DNA Repair Mechanisms
- Pain Mechanisms and Treatments
- Sirtuins and Resveratrol in Medicine
- interferon and immune responses
- Connexins and lens biology
- MicroRNA in disease regulation
- Phytoestrogen effects and research
- IL-33, ST2, and ILC Pathways
- Ginseng Biological Effects and Applications
Guangzhou University of Chinese Medicine
2022-2025
Shanghai First People's Hospital
2019-2022
Shanghai Jiao Tong University
2019-2022
Daqing Normal University
2021
Shanghai Institutes for Biological Sciences
2010
Center for Excellence in Molecular Cell Science
2010
Immune checkpoint blockade (ICB) immunotherapy increases antitumor immunity by blocking cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4) or programmed cell death 1 (PD-1)/programmed death-ligand (PD-L1) and displays robust clinical responses in various cancers. However, ICB also triggers severe inflammatory side effects, known as immune-related adverse effects (irAEs). One of the most common toxicities is immune blockade-associated colitis (ICB associated colitis). The exact mechanism...
Abstract Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, achieve bipolar division by clustering supernumerary centrosomes. Targeting is therefore considered a promising therapeutic strategy. However, the regulatory mechanisms of remain unclear. Here we report that KIFC1, regulator, positively associated with recurrence. Under DNA damaging treatments, ATM ATR kinases phosphorylate KIFC1...
Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of tumours. Immune checkpoint blockade (ICB) known involve adaptation, however, mechanism not fully known. Here we show, profiling plasma samples from melanoma-bearing mice undergoing anti-PD1 anti-CTLA4 combination therapy, that higher levels purine metabolites, including inosine, mark ICB sensitivity. Metabolic profiles ICB-treated human cancers confirm association between inosine In mouse models,...
Highlights•SIRT7 triggers microsatellite instability occurrence under DNA-damaging drug treatment•DNA-damaging drugs cause ATM kinase-dependent SIRT7 phosphorylation and redistribution•SIRT7 may serve as a predictive biomarker for chemotherapeutic efficacySummaryDrug resistance significantly limits the efficacy of chemotherapy. The DNA mismatch repair (MMR) system maintains genomic stability by correcting errors. During treatments, cancer cells transiently increase their adaptive mutability,...
Abstract The EMT (epithelial-to-mesenchymal-transition) subtype of gastric cancer (GC) is associated with poor treatment responses and unfavorable clinical outcomes. Despite the broad physiological roles micro-RNA (miR)-200 family, they largely serve to maintain overall epithelial phenotype. However, during late-stage tumorigenesis, members miR-200 family are markedly suppressed, resulting in transition mesenchymal state acquisition invasive properties. As such, represents a robust molecular...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storms constitute the primary cause of disease 19 (COVID-19) progression, severity, criticality, and death. Glucocorticoid anti-cytokine therapies are frequently administered to treat COVID-19, but have limited clinical efficacy in severe critical cases. Nevertheless, weaknesses these treatment modalities prompted development anti-inflammatory therapy against this infection. We found that broad-spectrum agent...
Central post-stroke pain (CPSP) is a neuropathic syndrome that frequently occurs following cerebral stroke. The pathogenesis of CPSP mainly due to thalamic injury caused by ischemia and hemorrhage. However, its underlying mechanism far from clear. In the present study, hemorrhage (TH) model was established in young male mice microinjection 0.075 U type IV collagenase into unilateral ventral posterior lateral nucleus medial thalamus. We found TH led microglial pannexin (Panx)-1, large-pore...
Abstract Regulatory T cell (Treg) deficiency leads to immune dysregulation, polyendocrinopathy, enteropathy, and X‐linked (IPEX) syndrome, which is a CD4 + cell‐driven autoimmune disease in both humans mice. Despite understanding the molecular cellular characteristics of IPEX new treatment options have remained elusive. Here, we hypothesized that salvianolic acid B (Sal B), one main active ingredients Salvia miltiorrhiza , can protect against disorders induced by Treg deficiency. To examine...
Abstract With the continuous development of automotive electronics, sensing technology has also appeared and been more widely used. As an important part electronic control system, sensors not only need to collect information, but transmit information. The automobile sensor first needs convert operating condition information into electrical signals then it central unit, in order make engine reach best working condition. In addition, can perform accurate real-time measurement for such as...
Abstract Metabolic alteration influences cancer immunity. However, the role and mechanism of metabolic adaption on immune checkpoint blockade (ICB) responses remains ill-defined. Here, to identify metabolites that modulate ICB sensitivity, metabolomic profiling in mouse tumor models patients treated with was performed. We identified metabolite inosine associated sensitivity mice humans, overcame resistance several models. Notably, sensitized cells T cell-mediated cytotoxicity by amplifying...