A5101562987- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Voice and Speech Disorders
- Gastrointestinal disorders and treatments
- Breast Cancer Treatment Studies
- Head and Neck Anomalies
- Gastrointestinal Tumor Research and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Medical Imaging and Analysis
- HVDC Systems and Fault Protection
- Cancer-related gene regulation
- Amoebic Infections and Treatments
- Streptococcal Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Vascular Malformations and Hemangiomas
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Dysraphism and Malformations
Fujian Provincial Cancer Hospital
2022-2025
Capital Medical University
2025
Fujian Medical University
2022-2025
Harbin Medical University
2021-2024
First Affiliated Hospital of Harbin Medical University
2021-2024
Guangdong University of Technology
2024
Guangzhou University
2024
Zunyi Medical University
2021-2022
First People’s Hospital of Zunyi
2020-2022
Tongji Hospital
2022
Head and neck squamous cell carcinoma (HNSCC) remains a prevalent lethal malignancy, with five-year survival rate of just 50% for cases locally advanced disease. Chromosomal aberrations, particularly the deletion short arm chromosome 3 (3p), have been strongly associated poor prognosis more aggressive tumor phenotypes. The microenvironment (TME) plays pivotal role in progression resistance to therapy. This study aims elucidate impact 3p on TME, immune infiltration, treatment response HNSCC,...
Glioblastoma multiforme (GBM) is the most aggressive primary tumor of central nervous system. As biomedicine advances, researcher has found development GBM closely related to immunity. In this study, we evaluated immunoreactivity and defined Immune-High (IH) Immune-Low (IL) immunophenotypes using transcriptome data from 144 tumors profiled by The Cancer Genome Atlas (TCGA) project based on single-sample gene set enrichment analysis (ssGSEA) five immune expression signatures (IFN-γ response,...
Background: Aerobic glycolysis plays a key role in tumor metabolic reprogramming to reshape the immune microenvironment. The phosphoglycerate kinase 1 (PGK1) gene codes glycolytic enzyme that converts 1,3-diphosphoglycerate 3-phosphoglycerate. However, lung adenocarcinoma (LUAD), of PGK1 altering microenvironment (TME) has not yet been determined. Methods: Raw data, including bulk DNA and mRNA-seq methylation modification single-cell RNA-seq proteomics clinical case characteristics survival,...
Abstract Intrathoracic goiter is commonly located in the anterior mediastinum. Here we report a case of 58-year-old Chinese male whom successfully removed intrathoracic and eased his dyspnea by right posterolateral thoracotomy approach. Posterior mediastinal thyroid with compressive symptoms an indication surgery.
The tumor microenvironment (TME), with hallmark features of hypoxia and immunosuppression, plays a crucial role in the progression various solid tumors. However, intricate interplay between formation immune glioma remains incompletely understood. In present study, we initially identified genes associated through GSEA IMMPORT database analysis. We subsequently hypoxia- immune-related prognosis further cross-analysis multidatabase integrated HSPA5 was ultimately as potential target gene...
Abstract Background Compared with conventional open surgery, endoscopic thyroidectomy via the oral vestibular approach (ETVOA) and areola (ETAA) avoided scarring of skin, which may help patients achieve a better quality life (QOL). However, benefit QOL from this technique has not been adequately investigated, therefore study compared outcomes between ETVOA ETAA. Methods 131 were enrolled in study. ETAA surgery performed 74 57 patients, respectively. These followed up at 2 weeks, 4 8 their...
<b><i>Background:</i></b> Gastrointestinal tumors originating from the muscularis propria are believed to have potential progress malignant tumors. The efficacy of ‘pre-management' with elastic band or endoloop assistant ligation after initial submucosal dissection in endoscopic enucleation procedure these was investigated and evaluated. <b><i>Methods:</i></b> study included 21 patients small gastric stromal arising as determined by endoscopy...
The composition of the population immune-related long non-coding ribonucleic acid (irlncRNA) generates a signature, irrespective expression level, with potential value in predicting survival status patients invasive breast carcinoma.The current study uses univariate analysis to identify differentially expressed irlncRNA (DEirlncRNA) pairs from RNA-Seq data Cancer Genome Atlas (TCGA). 36 DEirlncRNA were identified. Using various algorithms construct model, we have compared area under curve...
Primary systemic treatment (PST) downsizes the tumor and improves pathological response. The aim of this study is to analyze feasibility tolerance primary concurrent radio−chemotherapy (PCRT) in breast cancer patients. Patients with localized TN/HER2+ tumors were enrolled prospective study. Radiation was delivered concomitantly during first 3 weeks chemotherapy, it based on a 15 fractions scheme, 40.5 Gy/2.7 Gy per fraction whole nodal levels I-IV. Chemotherapy (CT)...
Purpose. Head and neck squamous cell carcinoma (HNSCC) exhibits a high mortality morbidity rate, its treatment is facing clinical challenges. Cuproptosis, copper-dependent death process, can help derive new forms of cancer therapies. However, the potential cuproptosis-related genes (CRGs) as novel biomarkers for risk prediction, screening, prognosis remains to be further explained in HNSCC. Methods. We built prognostic multigene signature with CRGs, which associated tumor immune...
Subacute thyroiditis (SAT) is a self-limiting, inflammatory thyroid disease possibly caused by viral infection. In recent years, the incidence of SAT increasing, especially during pandemic COVID-19. This study aimed to evaluate efficacy, safety, and recovery time capsular injection therapy under ultrasound guidance for SAT.A total 73 patients with were divided into two groups. Patients in group A (n = 48) received an ultrasound-guided consisting dexamethasone (DEX) lidocaine lesion area,...
The totally implantable venous access port (TIVAP) is an important device in patients for injecting blood products, parenteral nutrition or antineoplastic chemotherapy. Metastatic spread at the site of insertion a TIVAP extremely rare.We report case 33-year-old male with advanced gastrointestinal stromal tumor (GIST) who underwent radical resection after neoadjuvant imatinib therapy. However, solitary GIST metastasis developed during adjuvant treatment. Mutational analysis showed secondary...
Abstract Background Prostate cancer (PCa) is currently the major malignancy in men. It becoming increasingly clear that competitive endogenous RNA (ceRNA) regulation networks are important a wide variety of cancers. Nevertheless, there still much to learn about biological functions ceRNA network prostate cancer. Methods The was constructed using "GDCRNATools" package. Based on survival analysis, we obtained AC005154.6/hsa-miR-29c-3p/CCNL2 for further analysis. prognostic model based this by...
Breast cancer is notorious for its high mortality and heterogeneity, resulting in different therapeutic responses. Classical biomarkers have been identified successfully commercially applied to predict the outcome of breast patients. Accumulating biomarkers, including non-coding RNAs, reported as prognostic markers with development sequencing techniques. However, there are currently no databases dedicated curation characterization cancer. Therefore, we constructed a curated database (PMBC)....
Nasopharyngeal carcinoma (NPC) is a type of malignant tumors commonly found in Southeast Asia and China, with insidious onset clinical symptoms. N6-methyladenosine (m6A) modification significantly contributes to tumorigenesis progression by altering RNA secondary structure influencing RNA-protein binding at the transcriptome level. However, mechanism role abnormal m6A nasopharyngeal remain unclear.
Abstract Background: Breast cancer (BC) surpassed lung as the most frequent malignant tumour in women. In recent years, pyroptosis has revealed itself an inflammatory form of programmed cell death. However, it is unclear to expression genes associated with BC and its relationship prognosis. Results: this study, we identified 31 regulators that are differentially expressed between normal breast. The differently (DEG) allow patients be divided into three subtypes. Through single-factor...
Abstract Background : Endoscopic thyroidectomy via the oral vestibular approach (ETVOA) and endoscopic areola (ETAA) are becoming more favored in China. Compared with conventional open surgery, both methods avoid scarring on neck, but only ETVOA obviates of skin, which may helps patients achieve a better quality life (QOL). However, benefit QOL from this technique has not been adequately investigated, therefore study compared outcomes between ETAA. Methods We enrolled 131 study. ETAA surgery...
Intravenous leiomyomatosis (IVL) with intracardiac extension is a rare disease which has low diagnosis rate before operation. The article reported that 46-year-old patient suffering from IVL was admitted in the Tianjin First Center Hospital on September 2, 2014. CT and PET-CT revealed bilateral ovarian cyst, pelvic nodules, pulmonary mass existed IVC to right ventricle (maximum area of 12 cm × 4 cm).The diagnosed as extension. Then underwent myomatectomy adnexectomy successfully under...
Some micro arteriovenous malformations (AVMs) located in deep brain are undetectable. How to choose a proper timing detect these AVMs remains unclear. A 21-year-old male patient was admitted our center for intraventricular haematoma. Digital subtraction angiographies (DSAs) were performed one week and month respectively after his haemorrhage, but no positive results obtained. The hospitalized re-haemorrhage six years later. AVM with two diffused niduses detected embolised three months...
Objective To explore the ultrasonic characteristics of cystic adventitial disease (CAD) and to evaluate value color Doppler ultrasound in diagnosis CAD. Methods We retrospectively analyzed ultrasonograms other imaging methods eight patients with CAD conformed by surgery The first Hospital China Medical University. Results Five cases were confirmed before surgery, three misdiagnosed. All single, five popliteal artery, two iliofemoral one external iliac vein. We divided cysts into...
Objective To study the effective methods to treat injuries roots of hepatic veins and retrohepatic vena cava (RHC).Methods From January 1,2006 December 31,2012,we treated 6 cases with RHC.Different approaches were used achieve vascular exclusion (HVE) according sites injuries.We also reviewed experience reported in medical literature.Results Of patients,2 died intraoperatively,1 postoperatively,3 patients survived.Although there are RHC,the mortality rate is still high.It a major challenge...
Cavernous Transformation of the Portal Vein is a rare complication portal vein thrombosis or thrombophlebitis (PVT). (pylephlebitis) most commonly due to Bacteroides fragilis and Escherichia coli. PVT streptococcus constellatus bacteremia very rare, with gastrointestinal tract being common source infection. 53-year-old male who presented emergency room complains generalized abdominal pain, decreased appetite chills on off for 6 weeks. On examination he was hemodynamically stable, afebrile,...
Abstract Background: This study aimed to explore the use of percutaneous vertebroplasty (PVP) plus radiotherapy in patients with bone metastases. However, combined intensity modulated (IMRT) has been rarely reported treatment spinal Methods: The effectiveness and feasibility this procedure were initially observed paper. We retrospectively analyzed clinical characteristics 7 metastasis. They all treated PVP, followed by IMRT (6 MV-X linear at a dose 40-60 Gy) for 4-6 weeks. All achieved...