A5024431483- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- Prostate Cancer Treatment and Research
- Orthopaedic implants and arthroplasty
- Effects of Radiation Exposure
- Advanced Drug Delivery Systems
- Radiation Dose and Imaging
- Optical Imaging and Spectroscopy Techniques
- bioluminescence and chemiluminescence research
- Lung Cancer Treatments and Mutations
- Chemotherapy-induced cardiotoxicity and mitigation
- Medical Imaging and Pathology Studies
- Cancer, Lipids, and Metabolism
- Chemokine receptors and signaling
- Medical and Biological Sciences
- Osteoarthritis Treatment and Mechanisms
Universidad Autónoma del Estado de México
2015-2024
Tribunal Electoral del Estado de México
2018
Medicina
2018
Instituto Nacional de Investigaciones Nucleares
2015-2016
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2015
177 Lu-labeled nanoparticles conjugated to biomolecules have been proposed as a new class of theranostic radiopharmaceuticals. The aim this research was synthesize Lu-dendrimer(PAMAM-G4)-folate-bombesin with gold (AuNPs) in the dendritic cavity and evaluate radiopharmaceutical potential for targeted radiotherapy simultaneous detection folate receptors (FRs) gastrin-releasing peptide (GRPRs) overexpressed breast cancer cells. p-SCN-Benzyl-DOTA aqueous-basic medium dendrimer. carboxylate...
The biological tissue has been mimicked and replaced by other materials, which have shown certain radiological similarity determined attenuation coefficient (μ), density atomic number. Specifically, in molecular imaging radiation therapy developed multifunctional radiopharmaceuticals contain beta/gamma and/or light emitters to chronic degenerative diseases treatment. Therefore, it is necessary develop phantoms that allow optical radiometric characterization. Since the agar gel be a medium...
<sup>99m</sup>Tc-HYNIC-DA incorporated into HDL nanoparticles can be used to image SR-B1 positive tumors.
Clinical studies in women using technetium-99m (Tc)-Bombesin have shown successful radionuclide imaging of breast tumours overexpressing gastrin-releasing peptide receptors (GRPRs). Recent demonstrated that most overexpress folate (FRα).The aim this work was to synthesize the Lys(α,γ-Folate)-Lys(Tc-EDDA/HYNIC)-Bombesin (1-14) conjugate (Tc-Bombesin-Folate), as well assess in-vitro and in-vivo potential radiopharmaceutical target FRα GRPR.LysLys(HYNIC)-Bombesin conjugated folic acid product...
Actinium-225 and other alpha-particle-emitting radionuclides have shown high potential for cancer treatment. Reconstituted high-density lipoproteins (rHDL) specifically recognize the scavenger receptor B type I (SR-BI) overexpressed in several types of cells. Furthermore, after rHDL-SR-BI recognition, rHDL content is injected into cell cytoplasm. This research aimed to prepare a targeted 225Ac-delivering nanosystem by encapsulating radionuclide nanoparticles. The synthesis was performed two...
Pancreatic cancer is highly lethal and has a poor prognosis. The most common alteration during the formation of pancreatic tumors activation KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) oncogene. As new therapeutic strategy, C19 molecule ((2S)- N -(2,5-dichlorophenyl)-2-[(3,4-dimethoxyphenyl)-methylamine]propanamide) blocks KRAS-membrane association in cells. In addition, chemokine receptor CXCR4 overexpressed cancer. this research, dendrimer-based nanoradiopharmaceutical ( 177...
Reconstituted high-density lipoproteins (rHDLs) can transport and specifically release drugs imaging agents, mediated by the Scavenger Receptor Type B1 (SR-B1) present in a wide variety of tumor cells, providing convenient platforms for developing theranostic systems. Usually, phospholipids or Apo-A1 on particle surfaces are motifs used to conjugate molecules multifunctional purposes rHDL nanoparticles. Cholesterol has been less addressed as region bind functional groups surface. To maximize...
Abstract Hybrid nanosystems have useful properties for preparing therapeutic systems. Among the most commonly used inorganic components in hybrid are gold nanoparticles (AuNP). The design of these may require AuNP hydrophilic or hydrophobic nature. Upon irradiation AuNP, reactive oxygen species (ROS) formed, and temperature surrounding medium rises, depending on size, shape structure nanoparticle. aim this work is to evaluate whether irradiating 5 nm spherical both ‘bare’ (AuNP)...
Although liposomal doxorubicin (LPD) is widely used for cancer treatment, knowledge concerning the toxicity induced by this drug in healthy organs and tissues limited. LPD-induced studies relative to free (DOX) have focused on cardiotoxicity tumor-bearing animals. On other hand, results DOX-induced depending gender are controversial. One of manifestations tissue inflammation. 67Ga-citrate has been decades assess inflammation various pathologies. In work, ex vivo biodistribution evaluate...
Cerenkov radiation (CR) can be used as an internal light source in photodynamic therapy (PDT). Methotrexate (MTX) and paclitaxel (PTX), chemotherapeutic agents with wide clinical use, have characteristics of photosensitizers (PS). This work evaluates the possibility photoexciting MTX PTX CR from 18F-FDG to produce reactive oxygen species (ROS) capable inducing cytotoxicity. did not ROS when excited by 18F-FDG, so it is useful for PDT. In contrast, produces 1O2 (detected ABMA) amounts...
Recently, it was demonstrated that doxorubicin (Dox.HCl), a chemotherapeutic agent, could be photoactivated by Cerenkov radiation (CR). The objective of the present work to develop multimodal chemotherapy-radiotherapy-photodynamic therapeutic system based on reconstituted high-density lipoprotein (rHDL) loaded with Dox.HCl and 177Lu-DOTA. 177Lu acts as radionuclide CR source. can visualized nuclear imaging. Fluorescence microscopy showed rHDL-Dox specifically recognized cancer cells (T47D)...